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Nimulid 1% gel in 30g tube




The instruction for medical use

of NIMULID medicine
the Trade name

Mezhdunarodnoye the unlicensed

name Nimesulide Dosage Form
Transdermalny gel of 1%

One gram of gel contains
active agent – Nimesulide of 10 mg,
excipients: hydroxypropyl cellulose, carbomer 940, ethanol, purified water, triacetin, N.N-dimetilatsetamid, a ratstvoritel And, aromatic substance – MSC-03, aromatic substance – 0106-G.
The description
the Gel mass of a yellowish shade with a specific smell.
Pharmacotherapeutic group
Other nonsteroid anti-inflammatory drugs.
Automatic telephone exchange code: MO1AX17
the Pharmacological

Pharmacokinetics At properties putting transgel works the system of microtransport. The agent of penetration who vzaymodeystvut with lipids of a corneal layer of skin and leads to strengthening of penetration of medicine through skin contains drug. Also when passing drug through skin the presence of alcohol in structure Nimulid of transgel matters. When putting gel on skin alcohol evaporates, there is a film containing uniformly scattered vials of drug which easily get through skin and are better soaked up.
A pharmacodynamics
Nimulid – non-steroidal anti-inflammatory drug. Has anti-inflammatory and analgeziruyushchy effect. As a result of selection an ingibirovangiya of TsOG-2 enzyme (cyclooxygenase-2). synthesis of prostaglandins in the inflammation center is selectively slowed down. Nimulid also inhibits synthesis of leukotrienes, a factor of activation of thrombocytes, regulates migration of neutrocytes through an endothelium of vessels, reduces a histamine exit from mast cells, eliminates inflammation and hypostasis, slows down action of tumor necrosis factor (TNFα) promoting accumulation of bradykinin and cytokines which cause pain. Drug reduces aggregation of anions of superoxide with mature leukocytes, without affecting their phagocytal activity and preventing their further alteration. Nimulid inhibits a collagenase and metalprotease, reducing degradation of a cartilage and preventing progressing of an osteoarthritis.
– arthralgias
– acute and posttraumatic diseases of the musculoskeletal system (the tendinitis, tendosinovit, a bursitis, osteoporosis, a pseudorheumatism, arthrosis)
– back pains, to myalgia (pains of weak and average intensity)
the Route of administration and doses
Nimulid in the form of transdermalny gel is intended for external use by the adult and to children 12 years are more senior.
Route of administration: 3 cm of gel easily rub in skin over an affected area 3-4 times a day. The amount of gel can vary depending on the area of the processed site and reaction of the patient. Use frequency – no more than 4 times a day. The result on a kuaprovaniye of pain is estimated in several hours.
Course of treatment of 7-15 days.
Side effects
– irritation of skin, an erythema, skin rash, peeling, an itching on the site of application of gel, tranzitorny discoloration of skin.
The contraindication
– hypersensitivity to Nimesulide and other components of drug
– age up to 12 years
– pregnancy and the period of a lactation
Medicinal interactions
Quantity of significant vzaymodeystviye with other medicines at topical administration of Nimulid is noted.
The special
instructions Drug should not be applied on mucous membranes, including a conjunctiva, and a tkzha on the infected, damaged sites of skin and open wounds.
It is not necessary to put strongly to rub gel in skin.
The sites processed by gel cannot be closed occlusive bandages.
Influence on ability to driving of m potentially dangerous mechanisms
Drug does not affect ability to driving and potentially dangerous mechanisms.
Overdose and treatment
At topical administration overdose by drug it is improbable.
A form of release and packing
Transdermalny gel of 1% 30 g in plastic tubas together with the instruction for use in a cardboard box.

To Store storage conditions far from a source of heat and direct sunshine in at a temperature no more than +30 °C. Not to freeze.
To store drug out of children’s reach!

3 years
not to use an expiration date and storage after the expiration date specified on packing.
Prescription status
Without prescription

of Proizvoditel Panatseya Biotek Ltd
Malpur, Buddy, Tejsil Nalagarj
Rayon Solana (H.P.) – 173205, India

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