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Polyoxidonium 12 mg (10 tablets)

$53.20

1e6780831003

Description

The instruction for medical use of Polioksidoniy® medicine the Trade name of Polioksidoniy® the International unlicensed name Azoksimera bromide the Dosage form of the Tablet, 12 mg Structure One tablet contains active agent – an azoxymeasure bromide of 12 mg, excipients: Mannitolum, povidone, lactoses monohydrate, potato starch, stearic acid. The description Round ploskotsilindrichesky tablets of color, white or white with a yellowish shade, with a facet, with risky – from one party and with stamping ON – with another. Pharmacotherapeutic group Anti-neoplastic and immunomodulatory drugs. Immunostimulators. The ATX L03 code the Pharmacological Azoksimer’s Pharmacokinetics properties bromide after intake is quickly soaked up from a GIT, bioavailability of drug at oral introduction more than 70%. The maximum concentration in blood plasma is reached in 3 hours after intake. Azoksimer’s pharmacokinetics of bromide is linear (concentration in blood plasma is proportional to the accepted dose). Azoksimera bromide is hydrophilic connection. The seeming volume of distribution is about 0.5 l/kg that says that drug is distributed generally in intercellular liquid. The semi-absorption period – 35 minutes, elimination half-life – 18 hours. Azoksimera bromide is quickly distributed on all bodies and body tissues, gets through hematoencephalic and hemato-ophthalmic barriers. The cumulative effect is absent. In Azoksimer’s organism bromide is exposed to biological degradation to low-molecular oligomers, is removed mainly by kidneys, with excrements – no more than 3%. Azoksimer’s pharmacodynamics bromide possesses complex action: immunomodulatory, detoksitsiruyushchy, antioxidant, moderate anti-inflammatory. A basis of the mechanism of immunomodulatory action of Azoksimer of bromide is direct impact on englobing cells and natural killers and also stimulation of antibodyformation and synthesis of interferon alpha and interferon – gamma. Detoksikatsionny and antioxidant Azoksimera properties of bromide in many respects are defined by structure and the high-molecular nature of drug. Azoksimera bromide increases resistance of an organism concerning local and generalized infections of a bacterial, fungal and virus etiology. Restores immunity in the secondary immunodeficiency caused by various infections, injuries, complications after surgeries. Characteristic of Azoksimer of bromide at topical (sublingual) administration is the ability to activate factors of early protection of an organism against an infection: drug stimulates bactericidal properties of neutrophils, macrophages, enhances their ability to absorb bacteria, increases bactericidal properties of saliva and secretion of mucous upper airways. At oral administration of Azoksimer, bromide activates also lymphoid cells in lymph nodes of intestines. Azoksimera bromide blocks soluble toxic substances and microparticles, has ability to bring toxins, salts of heavy metals out of an organism, inhibits peroxide oxidation of lipids, both due to interception of free radicals, and by means of elimination catalystically of active ions of Fe2+. Azoksimera bromide reduces inflammatory reaction by means of normalization of synthesis about – and anti-inflammatory cytokines. Azoksimera bromide is well had, has no mitogenetic, polyclonal activity, antigenic properties, does not render allergenic, mutagen, embriotoksichesky, teratogenic and cancerogenic action. Azoksimera bromide has no smell and taste, does not possess local irritative action when drawing on mucous membranes of a nose and a stomatopharynx. Indications it Is applied at adults and children of 3 years to treatment and prevention of acute and chronic respiratory diseases in a stage of aggravation and remission. For treatment (in complex therapy): · sharp and exacerbations of chronic recurrent infectious and inflammatory diseases of a stomatopharynx, near-nasal bosoms, upper and lower airways, inner and middle ear, · the allergic diseases (including a pollinosis, bronchial asthma) complicated by a recurrent bacterial, fungal and viral infection For prevention (monotherapy): · recurrent herpes infection of nasal and labial area, · aggravations of the chronic centers of infections of a stomatopharynx, near-nasal bosoms, upper airways, inner and middle ear, · the secondary immunodeficiency arising owing to aging or influence of adverse factors. A route of administration and doses Use drug only according to those indications, that route of administration and in those doses which are specified in the instruction. If after treatment of improvement does not come or symptoms are aggravated, or there are new symptoms, it is necessary to consult with the doctor. Orally and sublingual in 20-30 min. prior to food daily 2 times a day: to children 10 years and the adult are more senior – on 1 tablet, children are from 3 to 10 years old – on ½ tablets (6 mg). If necessary carrying out repeated courses of therapy in 3-4 months is possible. At repeated prescribing of drug its efficiency does not decrease. The recommended schemes of treatment it is sublingual For treatment by the adult: · flu and acute respiratory infections – on 1 tablet 2 times a day 7 days, · inflammatory processes of a stomatopharynx – on 1 tablet 2 times a day within 10 days, · exacerbations of chronic diseases of upper airways, near-nasal adnexal bosoms, chronic otitises – on 1 tablet 2 times a day within 10 days, · the allergic diseases (including a pollinosis, bronchial asthma) complicated by a recurrent bacterial, fungal and viral infection – on 1 tablet 2 times a day within 10 days. For treatment to children from 3 to 10 years: · flu and acute respiratory infections – on ½ tablets 2 times a day 7 days, · inflammatory processes of a stomatopharynx – on ½ tablets 2 times a day within 7 days, · the allergic diseases (including a pollinosis, bronchial asthma) complicated by a recurrent bacterial, fungal and viral infection – on ½ tablets 2 times a day within 7 days. For treatment to children 10 years are more senior: · flu and acute respiratory infections – on 1 tablet 2 times a day 7 days, · inflammatory processes of a stomatopharynx – on 1 tablet 2 times a day within 7 days, · exacerbations of chronic diseases of upper airways, near-nasal adnexal bosoms, chronic otitises – on 1 tablet 2 times a day within 7 days, · the allergic diseases (including a pollinosis, bronchial asthma) complicated by a recurrent bacterial, fungal and viral infection – on 1 tablet 2 times a day within 7 days. For prevention by the adult: · flu and acute respiratory infections during the preepidemic period – on 1 tablet a day within 10 days, · a recurrent herpes infection of nasal and labial area – on 1 tablet 2 times a day 10 days, · aggravations of the chronic centers of infections of a stomatopharynx, near-nasal bosoms, upper airways, an inner and middle ear – on 1 tablet of times a day 10 days, · the secondary immunodeficiences arising owing to aging or influence of adverse factors – on 1 tablet once a day 10 days. For prevention to children from 3 to 10 years: · flu and acute respiratory infections during the preepidemic period – on ½ tablets a day within 7 days, · a recurrent herpes infection of nasal and labial area – on ½ tablets 2 times a day 7 days, · aggravations of the chronic centers of infections of a stomatopharynx, near-nasal bosoms, upper airways, an inner and middle ear – on ½ tablets of times a day 10 days. For prevention to children 10 years are more senior: · flu and acute respiratory infections during the preepidemic period – on 1 tablet a day within 7 days, · a recurrent herpes infection of nasal and labial area – on 1 tablet 2 times a day 7 days, · aggravations of the chronic centers of infections of a stomatopharynx, near-nasal bosoms, upper airways, an inner and middle ear on 1 tablet of times a day 10 days. Orally For treatment by the adult: · diseases of upper and lower airways – on 1 tablet 2 times of 10 days. For treatment to children 10 years are more senior: · diseases of upper and lower airways – on 1 tablet 2 times of 10 days. Side effects Side effects are not registered. If you noticed any side effects which are not specified in the instruction, report about it to the doctor. Contraindications · the increased individual sensitivity, · pregnancy, breastfeeding period, · children’s age up to 3 years, · acute renal failure, · rare hereditary lactose intolerance, deficiency of lactase, syndrome of glyukozo-galaktozny malabsorption. With care If you have diseases specified in this section, see a doctor before intake of medicine: · chronic kidney disease (apply not more often than 2 times a week). Medicinal interactions of Azoksimer bromide does not inhibit isoenzymes of CYP1A2, CYP2S9, CYP2S19, CYP2D6, R-450 cytochrome therefore drug is compatible to antibiotics, antiviral, antifungal and antihistaminic drugs, glucocorticosteroids and cytostatics. If you take above-mentioned or other medicines (including nonprescription), before Polioksidoniya’s reception consult with the doctor. Special instructions Attentively read this instruction before beginning use of this drug as it contains information, important for you. Keep the instruction, it can be required again. If you had questions, see a doctor. This medicine is released without prescription. For achievement of optimum results it should be used, strictly implementing all recommendations stated in the instruction. Medicine by which you are treated is intended personally to you, and he should not be transferred to other persons as it can do them harm even in the presence of the same symptoms, as at you. At development of allergic reaction it is necessary to stop use of the drug Polioksidoniy® and to see a doctor. In need of the termination of administration of drug of Polioksidoniy® the cancellation can be carried out at once, without gradual reduction of a dose. In case of the admission of introduction of the next dose of drug the subsequent its use should be carried out in the usual mode as it is specified in this instruction or it is recommended the doctor. The patient should not enter the doubled dose for the purpose of compensation of the passed doses. Do not use drug with visual signs of its unfitness (defect of packing, discoloration of a tablet). Use at pregnancy and a lactation is contraindicated drug Polioksidoniy® use to pregnant women and women during breastfeeding (clinical experience of use is absent). Before drug Polioksidoniy® use if you are pregnant, or you assume that you could be a pregnant woman, or you plan pregnancy, it is necessary to consult with the doctor. During breastfeeding before use of the drug Polioksidoniy® it is necessary to consult with the doctor. Features of influence of medicine on ability to run vehicles or potentially dangerous mechanisms Use of the drug Polioksidoniy® does not affect ability to performance of potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions (including control of vehicles, work with moving mechanisms). Overdose Cases of overdose are not registered. The form of release and packing On 10 tablets place in blister strip packaging from a film of the polyvinylchloride and printing aluminum foil varnished. One or two blister strip packagings together with the instruction for medical use in the state and Russian languages are placed in a pack from cardboard. To Store storage conditions at a temperature not above 25 °C. To store out of children’s reach! Period of storage 2 years. Not to apply after an expiration date. Prescription status Without prescription. Name and country of the organization producer/packer of LLC NPO Petrovax Pharm, Russian Federation, 142143, Moscow region, city of Podolsk, page. A cover, Sosnovaya St., 1 the Name and the country of the holder of the registration certificate of LLC NPO Petrovax Pharm, the Russian Federation the Name, the address and a contact information (phone, the fax, e-mail) of the organization in the territory of the Republic of Kazakhstan, the accepting claim (offer) on quality of medicines from consumers and responsible for post-registration observation of safety of medicine: KFK Medservice Plus LLP, Republic of Kazakhstan, Almaty, Mametova St., 54. Phone number: +7 (727) 279-86-02. Fax: +7 (727) 279-98-21
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