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Pio bacteriophage liquid 4’s 20 ml liq. for oral administration, for local and external application in (vial)




The instruction for medical use

of medicine

of Pío a bacteriophage liquid

the Trade name

of Pío a bacteriophage liquid

the International unlicensed name

Is not present

the Dosage form

Liquid for intake, topical and external use

the Structure

of 1 ml of drug contains

active agent:

Mix sterile filtrate of fagolizat of bacteria:



Escherichia coli.


Pseudomonas aeruginosa,

caption of a phage not less than 1х106,

excipient: there is

no Description

Transparent liquid of yellow color of various intensity with specific taste.

Pharmacotherapeutic group

Antibacterial drugs for system use.

Other antibacterial

drugs ATX J01XX Code Pharmacological Pharmacokinetics Irrespective of Properties of a method of administration, drugs of bacteriophages get into blood and a lymph and get to the inflammation center. The main part of drug is removed by kidneys, rendering the sanifying effect on urinary tract, and the rest – through digestive tract.

The pharmacodynamics

the Bacteriophage is a specific virus of a bacterium which is adsorbed on a cell membrane of a homological bacterium, gets into a cell and lyses it. Only virulent phages of bacteria are Pío’s part a bacteriophage liquid selection: Streptococcus, Staphylococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus that provides high activity and efficiency of drug.


Treatment and prevention of the pyoinflammatory diseases caused by bacteria of Streptococcus, Staphylococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus

– an infection of ENT organs and airways (inflammation of bosoms of a nose, middle ear, a tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy)

– surgical infections (purulent wound, a burn, abscess, phlegmon, a furuncle, an anthrax, a hydroadenitis, a felon, a paraproctitis, mastitis, a bursitis, osteomyelitis)

– urogenital infections (an urethritis, cystitis, pyelonephritis, a colpitis, an endometritis, a salpingo-oophoritis)

– digestive tract infections (stomatitis, a periodontal disease,

cholecystitis, a coloenteritis, an intestinal dysbiosis)

– generalized septic diseases

– pyoinflammatory diseases of newborns (omphalitis, a pyoderma, conjunctivitis, sepsis)

– processing of fresh wounds for prevention of purulent complications at surgical manipulations and operations

– prevention of bacterial complications in acute respiratory

viral diseases

the Route of administration and doses

the Important condition of successful use of drugs of bacteriophages is definition of a phagosensitivity of the activator and earlier drug use. Drug in an initial stage of a disease is especially effective and at use directly in the defeat center.

Pío a bacteriophage liquid is appointed for intake (through a mouth, in the form of enemas), locally (in the form of rinsings, irrigations, lotions), for introduction to a cavity (a wound, abscess, belly, pleural cavities, phlegmon, a nose, bosoms of a nose, a middle ear, a bladder, a uterus, a vagina).

For treatment of gnoino-vospolitelny diseases with lokalnyy defeats of Pío the bacteriophage liquid is appointed at the same time: as locally, so for intake (per os). Duration of a course of treatment drug from 5 to 10 days.

The dosage is defined individually, depending on the sizes of an affected area. The drug is administered in a center cavity after removal of pus by means of a puncture. The amount of the administered drug has to be slightly less than the volume of remote pus.

In the next days, the drug in the infected cavity, by means of a drainage is administered.

The procedure is carried out once a day, within 3-5 days.

& middot, In cystitis, pyelonephritises, uretrita the drug is taken inside.

In case the cavity of a bladder or a renal pelvis are trained, the bacteriophage is entered by 2 times a day on 20-30 ml into a bladder and on 5-10 ml in a renal pelvis,

& middot, In pyoinflammatory gynecologic diseases the drug is administered in a cavity of a vagina, a uterus, in a dose of 5-10 ml daily, once.

& middot, In pyoinflammatory diseases of an ear, throat, a nose the drug is administered in a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, by washings, burying, introductions of the moistened turundas (leaving them for 1 hour). For treatment of purulent Tonsillitis drug is used for rinsing and is appointed also, per so, at the same time.

& middot, At treatment of stomatitises and chronic generalized parodontit drug is used in the form of rinsings of an oral cavity 3-4 times a day in a dose of 10-20 ml and also to be entered into the parodontalny pockets of a turunda impregnated piobakteriofagy for 5-10 minutes.

& middot, At intestinal forms of a disease, diseases of internals, dysbacteriosis, Pío a bacteriophage liquid is applied through a mouth and in an enema.

Drug is allowed to drink on an empty stomach, in 1 hour prior to food.

In the form of enemas it is appointed 1 time a day, in the evening, before going to bed, after bowel emptying.

The recommended drug dosages:

The age

through a mouth

in an enema

Up to 6 months

of 5 ml x once a day

10 ml x once a day

From 6 to 12 months

5 ml x 2 times in day

of 10 ml x once a day

From 1 year to 3 years

5 ml x 3 times in day

of 20 ml x once a day

From 3 to 8 years

10 ml x 2-3 times in day

of 30 ml x once a day

Also is more senior than 8 years

20 ml x 2-3 times in day

of 40 ml x once a day

The drug dose for preventive use

is defined by the doctor.

The note

In case before use of drug of Pío of a bacteriophage chemical antiseptic agents were applied to treatment of wounds, the wound has to be carefully washed sterile 0.9% with chloride sodium solution.

Side effects
Drugs of bacteriophages are non-toxic. The undesirable effects and reactions connected with Pío’s use a bacteriophage liquid are noted.


Hypersensitivity to any component of contents of a bottle of drug.

Medicinal interactions

Interaction with other medicines of drugs of bacteriophages is not established. Pío a bacteriophage liquid can be applied with other medicines including with antibacterial drugs.

Drug not to apply special instructions At turbidity!

Owing to the content in drug of nutrient medium in which bacteria from the environment can develop, causing drug turbidity, it is necessary to follow the following rules when opening a bottle:

– to carefully wash hands,

– to process a cap alcohol-containing solution,

– to remove a cap, without opening a stopper,

– not to put a stopper an internal surface on a table or other objects,

– not to leave a bottle open,

– to store the opened bottle only in the fridge.

When using small doses (2-8 drops), drug needs to be selected the sterile syringe of 0.5-1 ml.

Drug from the opened bottle at observance of storage conditions, above-mentioned rules and lack of turbidity can be used within 24 hours after opening, at storage in the corresponding conditions.

Pregnancy and the period of a lactation

Drugs of bacteriophages can be used during pregnancy and a lactation.

There is no feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Special instructions.


Symptoms of overdose of drugs of bacteriophages are unknown.

A form of release and packing

On 20 ml in a bottle from medical glass, on 4 bottles together with the instruction for medical use in a box cardboard.

Storage conditions

Drug is stored at a temperature 2os – 25os in the dry place protected from light.

To store out of children’s reach.

Period of storage

2 years.

Not to apply after the expiry date specified on packing.

Prescription status

Without prescription of the doctor.

JSC Biokhimpharm Adres producer: Gotua 3 St., Tbilisi 0160, Georgia,
Ph. +995 32 2 244777 / 2 244778, fax: +995 32 2 380895,
Al mail:,

Name and country of the owner of the registration certificate

of JSC Biokhimpharm Adres: Gotua 3 St., Tbilisi 0160, Georgia

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
the Representative in RK Almaty 050012 of Kazybek St. bi
house No. 125/198 phone number +7 707 723 27 72
+7 707 728 02 71
+7 727 301 81 83
the e-mail address:

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