Eye Care / Glaucoma

Okumed 5 ml of 0.5% eyedrops

Brands: Sentiss (India)

$8.10

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Okumed 5 ml of 0.5% eyedrops quantity

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57a53e24b2a6

Brands:: Sentiss (India)

Description

The instruction
for medical use

of OKUMED medicine

the Trade name
Okumed

Mezhdunarodnoye the unlicensed

name Timololum Dosage Form
of the Drop eye, 0.5%

Structure
of 1 ml of drug contains
active agent – Timololum a maleate, is equivalent to Timololum of 5.0 mg,
excipients: a benzalkoniya chloride, sodium phosphate disubstituted, sodium phosphate monosubstituted, water for injections.

Description
Transparent colourless solution.

Pharmacotherapeutic group
Drugs for treatment of diseases of eyes. Protivoglaukomny drugs
and miotik. Beta blockers. Timololum
the ATX S01ED01 Code

the Pharmacological

Pharmacokinetics Timololum properties is a non-selective blocker of beta adrenoceptors. Has no internal sympathomimetic and membrane stabilizing activity.
At topical administration in the form of eye drops reduces both the normal, and increased intraocular pressure due to reduction of formation of intraocular liquid. Does not influence the size of a pupil and accommodation.
At topical administration Timololum quickly gets through a cornea. After instillation of eye drops the maximum concentration of Timololum in watery moisture of an anterior chamber of an eye is reached in 1-2 hours.
In insignificant quantity gets to a system blood stream by absorption through vessels of a conjunctiva, mucous a nose and a plaintive path.
About 60-80% of Timololum are exposed to metabolism in blood plasma. Removal of metabolites of Timololum is carried out mainly by kidneys.
Pharmacodynamics
Protivoglaukomny means. Treats to group of beta blockers. Effect of drug is shown in 20 minutes after instillation in a conjunctival cavity. The maximum decrease in intraocular pressure occurs in 1-2 hours and remains within 24 hours. Decrease in intraocular pressure is 25% of initial level.

Indications
– the increased intraocular pressure (oftalmogipertenziya)
– an open angle glaucoma
– secondary glaucoma
– as an additional tool for decrease in intraocular pressure in closed-angle glaucoma (in a combination from miotika)
– congenital glaucoma (at insufficiency of other therapeutic measures)

the Adult dig in the Route of administration and doses in a conjunctival sac – on 1 drop of 0.5% of solution 2 times a day.
At normalization of intraocular pressure a maintenance dose – 1 drop once a day.
The Okumed drug treatment is carried out, as a rule, for an appreciable length of time. The break or change of a dosage are carried out only according to the instruction of the attending physician.

Side effects
Local reactions
– irritation and hyperaemia of a conjunctiva, an eyelid skin
– blepharitis
– burning and an itching of eyes
– dacryagogue or reduction of a slezootdeleniye
– a photophobia
– cornea epithelium hypostasis
– a dot superficial keratopathy
– a cornea giposteziya
– decrease in sensitivity of a cornea
– a diplopia
– a ptosis
– short-term disturbance of visual acuity
– xerophthalmus
– conjunctivitis
– a keratitis
When carrying out antiglaukomatozny operations is possible development of amotio of a choroid of an eye in the postoperative period.
System reactions
– heart failure, bradycardia, bradyarrhythmia, a lowering of arterial pressure, collapse, atrioventricular block, cardiac arrest, passing disturbances of cerebral circulation
– an asthma, a bronchospasm, pulmonary insufficiency
– a headache, dizziness, a myasthenia, a depression, paresthesias, drowsiness, hallucinations, a ring in ears, delay of speed of psychomotor reaction, fatigue, concern, nightmares, an asthenia
– urticaria, allergic contact dermatitis, a toxic epidermal necrolysis
– hypopigmentation, damage of nails, baldness, psoriasis, red flat deprive, eczema, an erythrosis
– stomatitis
– nausea, vomiting, diarrhea
– rhinitis, nasal bleeding
– a stethalgia
– decrease in potency
in case of side effects, it is necessary to stop use of drug and to see as soon as possible the attending physician.

Contraindications
– the increased individual sensitivity to Timololum and auxiliary components of drug
to Patients at whose anamnesis there are following diseases:
– bronchial asthma or other heavy chronic obstructive respiratory diseases
– sinus bradycardia
– atrioventricular block of II or III degree
– an acute heart failure
– chronic heart failure in a decompensation stage (III-IV functional class)
– cardiogenic shock
– allergic reactions with generalized skin rashes
– atrophic rhinitis
– dystrophic diseases of a cornea
– children’s and teenage age up to 18 years

Medicinal interactions
Joint prescribing of the drug Okumed with the eye drops containing epinephrine can cause mydriasis.
Specific effect of drug – decrease in intraocular pressure amplifies at simultaneous use of the eye drops containing epinephrine and pilocarpine it is not necessary to dig in two beta blockers in eyes.
The lowering of arterial pressure and delay of a warm rhythm can amplify at combined use of drug with blockers of slow calcium channels, reserpine and other beta blockers.
Simultaneous use with insulin or oral antidiabetic means can lead to a hypoglycemia.
It is impossible to apply at the same time with antipsychotic medicines (neuroleptics) and anxiolytic medicines (tranquilizers).
During treatment it is not recommended to accept ethanol (perhaps sharp lowering of arterial pressure).
Okumed strengthens action of peripheral muscle relaxants therefore drug withdrawal in 48 hours prior to the planned surgical intervention using the general anesthesia is necessary.
These data can belong also to medicines which were applied shortly before it.

Special instructions
It is regularly necessary to visit the doctor for measurement of intraocular pressure and inspection of a cornea.
If the patient carries soft contact lenses, then he should not apply eye drops Okumed of 0.5% as preservative can be laid in soft contact lenses and make an adverse effect on eye tissues.
It is necessary to remove rigid contact lenses before burying drug and to dress them again only 15 minutes later.
At transfer of patients to the Okumed drug treatment the correction of a refraction after the effects caused by the miotika applied earlier can be necessary.
In case of the forthcoming surgery using the general anesthesia, it is necessary to cancel drug in 48 hours.
With care
Okumed it is necessary to apply at patients with pulmonary insufficiency, heavy cerebrovascular insufficiency, heart failure in compensation stage, sinuatrial blockade, arterial hypotension, a hypoglycemia, a myasthenia, Reynaud’s syndrome, a pheochromocytoma, atrophic rhinitis and also at co-administration of other beta blockers and psychoactive medicines which strengthen epinephrine discharge.
Okumed can hide hypoglycemia symptoms at patients with diabetes and thyrotoxicosis symptoms at patients with hyperfunction of a thyroid gland.
After Okumed’s instillation it can be observed decrease in clearness of sight and delay of mental reactions that can reduce ability to active participation in traffic, service of cars or to performance of work without reliable support.
Pregnancy and the period of a lactation
Eye drops Okumed should not be used during pregnancy. Timololum is excreted in breast milk. Because of a possibility of serious side reactions on Timololum at babies, the decision on the termination either feedings by maternal milk, or drug uses, taking into account its importance for the nursing mother has to be made.
The feature influence on ability to run motor transport and potentially dangerous mechanisms
needs to be careful at control of motor transport and potentially dangerous mechanisms.

Overdose
Symptoms: dizziness, headache, arrhythmia, bradycardia, bronchospasm, nausea, vomiting.
Treatment: to immediately wash eyes with water or 0.9% chloride sodium solution, symptomatic therapy.

A form of release and packing
On 5 ml and 10 ml of drug in plastic bottles droppers.
On 1 bottle dropper together with the screw-on cap in which there is a device for opening of a bottle and with the instruction for medical use in the state and Russian languages place in a cardboard pack.

To Store storage conditions in the place protected from light at a temperature not above 25 °C.
Not to freeze.
To store out of children’s reach!

A period of storage
3 years
the use Period after opening of a bottle of 45 days.
Not to use after expiry date.

Prescription status
According to the prescription

of Proizvoditel SENTISS FARM PVT. LTD.
212/D-1, Greene Park, New Delhi, India
At the plant: Villidzh Khera Nikhla, Tekhsil Nalagarkh, Region of Solan, Himachal Pradesh 174,101, India

Name and country of the owner of the registration certificate
of SENTISS FARMA of PVT. LTD., India

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products: Republic of Kazakhstan, 050000, Almaty, Bogenbay St. of the Batyr 132, office 309 Ph./fax: +7 (7272) 96-45-99Email:
To Develop sentiss_kz@land.ru

Additional information