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Allergostop 4% Eye Drops 10 ml.

$4.90

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Description

Trade name
АЛЛЕРГОСТОП®

the International unlicensed
name Kromoglitsiyevaya acid

the Dosage form
of the Drop eye and nasal 4%

Structure
of 100 ml of solution contain
active agent – sodium kromoglikat 4.00 g,
excipients: a benzalkoniya chloride, water for injections.

The description
Transparent or slightly opalescent, from colourless till yellowish color, liquid.

Pharmacotherapeutic group
Decongestants and antiallergenic drugs.
The code of automatic telephone exchange S01GX01

the Pharmacological

Pharmacokinetics Absorption properties through a mucous membrane of an eye it is insignificant. The maximum antiallergenic effect is noted in the first 2 h after use, action duration to 4-6 h.
System bioavailability – less than 0.03%. Elimination half-life – 5-10 minutes. Communication with proteins of blood plasma – 65%.
After intranasal use & lt, 7% of a dose are absorbed from a nasal cavity, getting to a system blood stream. A major factor in ensuring therapeutic effect of drug is the concentration of sodium of the kromoglikat which is reached in a target organ after topical administration. Elimination half-life (T1/2) — 80 min.
Sodium kromoglikat is not metabolized. Drug is removed from an organism in equal quantities with urine and bile for 24 h in not changed look.
A pharmacodynamics
Suppressing degranulation of mast cells by stabilization of a cellular membrane, kromoglikat sodium prevents discharge of mediators of an allergy – a histamine, bradykinin, prostaglandins, leukotrienes, including slowly reacting substance and other biologically active agents. The activity of phosphodiesterase oppresses and increases concentration of tsAMF in a cell, blocks an entrance of calcium ions to cytosol. This mechanism of action is universal for all mucous membranes (a nose, eyes).
The greatest therapeutic effectiveness is reached at preventive use of drops. Therefore it is necessary to begin its use of emergence of symptoms of an allergy slightly earlier (it belongs to cases of a seasonal allergy).
The noticeable clinical effect occurs in several days, and maximum, 15 days later after reception.
Аллергостоп® effectively facilitates or completely removes the most part of symptoms of an allergy of eyes, showing the greatest activity in seasonal allergic, acute conjunctivitis, hay fever, vernalny and huge papillary keratoconjunctivites.
Аллергостоп® can also reduce hyperpermeability of vessels of a mucous membrane and limit access of allergen and nonspecific incentives to mast cells.

Indications
– prevention and treatment of acute and chronic conjunctivitis of an allergic etiology
– prevention and treatment of seasonal or year-round rhinitis of an allergic etiology, a pollinosis (hay fever)
– for simplification and removal of irritations of a mucous membrane of the eyes tied with allergic reactions to the polluted environment and means of household chemicals, to professional harm, including smoke, dust content, vapors of solvents and other chemicals, to effect of cosmetics and eye medicines, to plants and pets

the Route of administration and doses
to Adults and children are more senior than 8 years:
– in the form of eye drops dig in in a conjunctival sac on 1-2 drop 4 times a day through equal intervals of time (at achievement of effect the intervals between use gradually extend). If necessary it is possible to increase a daily dose to 6-8 burying.
– in the form of nasal drops in rhinitis dig in 1-2 drops of drug in each nasal course 3-4 times a day. It is possible to increase the frequency of burying to 6 times a day.
Аллергостоп® it is intended for long therapy. Preventive treatment of subacute and chronic processes should be begun before contact with allergen. Treatment needs to be continued until the patient is affected by allergens (pollen, house dust, spores of mushrooms, food-borne allergens). Use duration in chronic diseases is defined by the clinical course of the disease. It is regularly necessary to estimate therapeutic effect, and, in case of need, the dose decline is recommended.
It is necessary to watch that the tip of a bottle dropper did not contact to other objects or surfaces. After burying the bottle dropper is closed a cap.

Side effects
Often
– hyperaemia, burning sensation, local irritation of eyes (pass independently in 1-3 minutes)
It is rare
– temporary misting of sight after burying
– feeling of a foreign body in eyes
– the raised dacryagogue or xerophthalmus
– a meibomitis (barley)
– superficial damage of an epithelium of a cornea
– irritation or burning of a mucous membrane of a nose, an epistasis, sneezing, cough, a rhinorrhea
– light dryness in a throat, nasal bleeding
– a headache, dizziness, migraine
Very seldom
– short wind, a bronchospasm, a Quincke’s disease of the face, lips, language, a century, anaphylactic reactions, an arthralgia, rash, urticaria, a skin itching, the complicated breath, a dieback
– change of taste, a dysphagy, nausea, an abdominal pain
– arterial hypotension

of the Contraindication
– the increased individual sensitivity to drug and its components
– polyps in a nasal cavity (for intranasal forms)
– children’s age up to 8 years
the Medicinal interactions
For drug in the form of eye drops — are not established.
In case of use of other eye drops it is necessary to use them at an interval of 5 min.
There are no data on negative medicinal interaction of the kromoglikat of sodium in the form of nasal drops with other drugs at simultaneous use.
Аллергостоп® can enhance effect of antihistaminic drugs, β-adrenomimetik, glucocorticosteroids and theophylline.

Special instructions
At disturbance of integrity of a bottle, and also at solution turbidity, drug it is not necessary to use.
Аллергостоп® the benzalkoniya contains chloride which can cause irritation of eyes. Benzalkoniya can lead chloride to discoloration of soft contact lenses. Before lens drug use (any) should be removed and waited for at least 15 min. before dressing them again. At an acute inflammation and during aggravation of chronic process drug should be used in combination with antihistamines or corticosteroids. The patient has to be warned about need of regular use of drug. Treatment is begun before contact with allergen and continue the entire period of effect of allergen.
For acceleration of action it is possible to apply antiedematouses to a nose before use of Allergostop® in the form of nasal drops for 2–3 days.
Use in pediatrics
the Data on efficiency and safety of medicine at children up to 8 years are absent.
Pregnancy and the period of a lactation
of Sodium kromoglikat is allocated in breast milk in insignificant quantity therefore at use of drug during feeding by a breast the risk of harmful action on children of early age minimum or is practically absent.
Use of drug during pregnancy or the period of a lactation, is recommended only in cases when the expected effect of therapy exceeds potential risk for a fruit or the child.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms.
Drug affects sight only directly after drug use — for several minutes. Therefore the patient has to wait until there passes the sight zatumanennost before running the vehicle or to work with other potentially dangerous mechanisms.

Overdose
At topical administration of drug the cases of overdose are improbable and are not described.

A form of release and packing
On 10 ml in bottles droppers polyethylene, hermetically corked by the screwing-up covers with control of the first opening. On 1 bottle together with the instruction for medical use in the state and Russian languages in a pack cardboard.

To Store storage conditions at a temperature from 15 wasps up to 25 wasps, in the place protected from light.
After opening to store in densely closed packing and to use within 4 weeks.
To store out of children’s reach!

3 years
not to apply a period of storage after an expiration date.

prescription status Without prescription

Additional information

Ingredient

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