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Detralex® 36’s 500 mg film-coated tablets


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The instruction for medical use

of DETRALEX medicine

the Trade name


the International unlicensed name

Is not present

the Dosage form

of the Tablet, film coated


One tablet contains

active agents: the cleaned micronized flavonoidny fraction consisting of diosmin of 90% – 450 mg and flavonoids in the form of hesperidin of 10% – 50 mg,

excipients: gelatin, magnesium stearate, cellulose microcrystalline, starch sodium glycollate, talc, glitserol, macrogoal 6000, methylhydroxypropyl cellulose, gland (III) oxide red E172, sodium lauryl sulfate, titan E171 dioxide, gland (III) oxide yellow E172


of the Tablet of an oval form, film coated salmoncolored color

Pharmacotherapeutic group

Vasoprotectives. The drugs reducing permeability of capillaries. Bioflavonoids. Diosmin in a combination with other

drugs ATX C05CA53 Code Pharmacological Pharmacokinetics In Properties an organism drug biotransformirutsya to phenolic acids.

Detralex is removed from an organism generally through intestines. Kidneys remove 14% of the accepted dose. Elimination half-life (T1/2) makes 11 h.

The pharmacodynamics

Detralex has venotoniziruyushchy and angioprotektorny effect. Reduces extensibility of veins, raises their tone and reduces venous stagnation, reduces permeability of capillaries and increases their resistance, improves microcirculation, improves a lymphatic drainage.
At systematic use of Detralex the reduction of expressiveness of clinical symptoms of chronic venous insufficiency of the lower extremities of the organic and functional nature and also a hemorrhoidal disease is noted.


symptomatic treatment of venous and lymphatic insufficiency (weight in legs, pain, hypostases and spasms)

the functional symptoms connected with bad attacks of hemorrhoids.

A route of administration and doses

the Recommended dose makes 2 tablets a day, 1 tablet in the middle of the day and 1 tablet in the evening during meal.

At a bad attack of hemorrhoids: 6 tablets a day in the first 4 days (on 2 tablets 3 times a day), then on 4 tablets in the next 3 days (on 2 tablets 2 times a day).

Duration of a course of treatment is defined by the attending physician.

The average duration of treatment is 23 months.

Side effects


diarrhea, dyspepsia, nausea, vomiting




dizziness, a headache, a general malaise

skin rash, an itching, a small tortoiseshell

Frequency is not established

an abdominal pain

edema of face, lips, a century and a Quincke’s edema


hypersensitivity to drug

the lactation period

Medicinal interactions

there Are

no Special instructions

At bad attacks of hemorrhoids the use of Detralex does not replace specific treatment of other diseases of anorectal area. Drug is appointed a short course. At inefficiency of the carried-out treatment it is necessary to perform additional examination and to correct therapy. When prescribing drug the patients with disturbances of venous blood circulation should inform them on need of protection from long stay in the sun, long standing standing, decrease in body weight and wearing the special stockings improving blood circulation.


In pilot studies of teratogenic effect it is not revealed.

So far about any side effects at use of drug for pregnant women it was not reported.

Features of influence on ability to run the vehicle and potentially dangerous mechanisms

Detralex does not affect ability to run motor transport and potentially dangerous mechanisms.


of the Message about cases of overdose are absent.

Symptoms: strengthening of side effects

Treatment: symptomatic

the Form of release and packing

On 12 (for packing No. 36) or 15 (for packings No. 30 and No. 60) tablets place in blister strip packaging from a film of polivinilkhloridy and aluminum foil.

On 2 or 4 (for packings No. 30 and No. 60 respectively), or on 3 (for packing No. 36) blister strip packagings together with the instruction for medical use in the state and Russian languages place in a box of cardboard.

To Store storage conditions at a temperature not over 30C.

To store out of children’s reach!

A period of storage

4 years

not to use drug after the expiration date specified on packing.

Prescription status

Without prescription

Les Laboratoires Servier Industrie Producer (Le Laboratoir of Servye Indastri), France

the Owner of the registration certificate

of Les Laboratoires Servier (Le Laboratoir of Servye), France


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