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Benzylpenicillin 1 Mill. ED 1’s powder for solution for injection

$2.00

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Description

The instruction for medical use

of Benzilpenitsillin Torgovoye medicine a name
Benzilpenitsillin

Mezhdunarodnoye the unlicensed

name Benzilpenitsillin Lekarstvennaya a form
Powder for preparation of solution for intravenous and intramuscular administration of 1000000 PIECES

Structure
contains One bottle:

active agent – sodium benzylpenicillin (in terms of active agent) – 0.6 g (1000000 PIECES)

the Description
White or almost white fine-crystalline powder with a slight characteristic smell.

Pharmacotherapeutic group
Beta laktamnye antibacterial drugs – penicillin.
Penicillin penicillinase – sensitive. Benzilpenitsillin
the ATX J01CE01 Code

the Pharmacological

Pharmacokinetics Maximum Concentration properties in blood plasma at intramuscular introduction is reached in 20-30 min. Elimination half-life of drug makes 30-60 min., in a renal failure of 4-10 h and more. Communication with proteins of plasma – 60%.
Gets into bodies, fabrics and biological liquids, except liquor, tissues of an eye and prostate. At inflammation of meningeal covers the permeability
through a blood-brain barrier increases. Passes through a placenta and gets into breast milk. It is removed by kidneys in not changed look.
A pharmacodynamics
the Bactericidal antibiotic from group of biosynthetic (‘natural’) penicillin. Inhibits synthesis of a cell wall of microorganisms.
It is active concerning gram-positive activators: Staphylococcus spp. (not forming penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces spp., gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis and also concerning Treponema spp. It is inactive concerning the majority of gram-negative bacteria, rickettsiae, viruses, the elementary.
Penitsillinazoobrazuyushchy strains of microorganisms are resistant to effect of drug. Collapses in acidic environment.

Indications
the Bacterial infections caused by sensitive activators:
– lung and focal fever, a pleura empyema, bronchitis
– sepsis, a septic endocarditis (sharp and subacute), peritonitis
– meningitis
– osteomyelitis
– infections of an urinogenital system (pyelonephritis, a pyelitis, cystitis, an urethritis,
gonorrhea, blennoreya, syphilis, a cervicitis)
– infections of biliary tract (cholangitis, cholecystitis)
– a wound fever
– infections of skin and soft tissues: the ugly face, impetigo which are again infected a dermatosis
– diphtheria
– scarlet fever
– anthrax
– actinomycosis
– infections of ENT organs
– eyeball infections

the Route of administration and doses
Drug is intended for intramuscular, intravenous, hypodermic, endolumbar and intratracheal administration.
At a medium-weight course of the disease (an infection of lower parts of airways, urine – and biliary tract, an infection of soft tissues and others) – 4-6mln PIECE/days for 4 introductions.
At a heavy course of infections (sepsis, a septic endocarditis, meningitis, etc.) – 10-20 mln units a day, in gas gangrene – up to 40-60 mln units.
The daily dose for children aged till 1 year – 50000-100000 PIECES/kg, is more senior than 1 year – 50000 PIECES/kg, if necessary – 200000-300000 PIECES/kg, according to vital indications – increase up to 500000 PIECES/kg. Frequency rate of introduction – 4-6 times a day, intravenously – 1 – 2 time a day in combination with intramuscular injections.
Endolyumbalno is entered in purulent diseases of a head and spinal cord and a meninx.
Depending on a disease and weight of its course: adult – 5-10 thousand. Piece, to children – 2-5 thousand. The piece of 1 times a day within 2-3 days intravenously, then is appointed intramusculary.
For intravenous jet administration a single dose (1-2 million. Pieces) dissolve in 5-10 ml of sterile water for injections or 0.9% of solution of sodium of chloride and enter slowly, within 3-5 minutes.
For intravenous drop administration of 2-5 million. Pieces part 100-200 ml of 0.9% of solution of sodium of chloride or 5-10% of solution of a dextrose and enter with a speed of 60-80 of cap/min.
At drop introduction to children as solvent 5-10% use dextrose solution (100-300 ml depending on a dose and age).
Drug solution for intramuscular introduction is prepared just before introduction, adding to bottle contents 1-3 ml of water for injections or 0.9% of solution of sodium of chloride or 0.5% of solution of novocaine.
Solutions use right after preparation, without allowing addition to them of other medicines.
Subcutaneously drug is used for an obkalyvaniye of infiltrates in concentration 100-200 thousand. Piece in 1 ml of 0.25-0.5% of solution of novocaine.
Drug solution preparation for endolumbar use: dissolve drug in sterile water for injections or in 0.9% chloride sodium solution at the rate of 1 thousand. Piece/ml. Before an injection (depending on intracranial pressure) take 5-10 ml of medullispinal liquid and add it to antibiotic solution in an equal ratio.
Enter slowly (1 ml/min.), usually 1 time a day within 2-3 days, then pass to intravenous or intramuscular injections.
At suppurative processes in lungs enter drug solution intratrakhealno (after careful anesthesia of a pharynx, a throat and a trachea). Apply usually 100 thousand. Piece in 10 ml of 0.9% of solution of sodium of chloride.
In diseases of eyes (acute conjunctivitis, a helcoma, a honoblenorrhea and others) appoint the eye drops containing 20-100 thousand PIECES in 1 ml of 0.9% of solution of sodium of chloride or the distilled water. Enter 1-2 cap of 6-8 times a day.
In a nose apply the solutions containing 10 – 100 thousand PIECES/ml to ear drops or drops.
Drug treatment duration in dependence on a form and weight of a course of the disease – from 7-10 days to 2 months and more (for example, in sepsis, a septic endocarditis).

Side effects
– arrhythmias, cardiac arrest, chronic heart failure (since at introduction of high doses there can be a hypernatremia)
– nausea, vomiting, stomatitis, a glossitis, an abnormal liver function
– a renal failure
– anemia, a leukopenia, thrombocytopenia
– increase in reflex irritability, meningeal symptoms, spasms, a coma
– allergic reactions: a hyperthermia, a small tortoiseshell, skin rash, fever, a fever, the increased sweating, rash on mucous membranes, an arthralgia, an eosinophilia, a Quincke’s disease, interstitial nephrite, a bronchospasm, the Quincke’s edema
Seldom
– an acute anaphylaxis
– the superinfection caused by microflora, resistant to drug (yeast-like mushrooms, gram-negative microorganisms)
– local reactions: morbidity and consolidation in the place of intramuscular introduction

of the Contraindication
– hypersensitivity (including to other β-laktamny
antibiotics) to drug
– urticaria, bronchial asthma
– endolumbar introduction in epilepsy.
With care
– a renal failure.

Medicinal interactions
Bactericidal antibiotics (including cephalosporins, Vancomycinum, rifampicin, aminoglycosides) have sinergidny effect, bacteriostatic (including macroleads, chloramphenicol, linkozamida, tetracyclines) – antagonistic.
Increases efficiency of indirect anticoagulants (suppressing intestinal microflora, reduces the prothrombin ratio), reduces efficiency of oral contraceptives, medicines in the course of which metabolism paraaminobenzoic acid, ethinylestradiol – risk of developing bleedings of ‘break’ is formed.
Diuretics, Allopyrinolum, blockers of canalicular secretion, phenylbutazone, non-steroidal anti-inflammatory drugs, reducing canalicular secretion, increase Benzilpenitsillin’s concentration.
Allopyrinolum, at combined use increases risk of development of allergic reactions (skin rash).

Special instructions
drug Solutions for all ways of introduction prepare ekh tempore.
If through 2-3 (at most 5 days) after the beginning of use of drug of effect it is not noted, it is necessary to pass to use of other antibiotics or combination therapy. At the weakened patients, newborns, people
of advanced age at long-term treatment the development of the superinfection caused by microflora, resistant to drug (yeast-like
mushrooms, gram-negative microorganisms) is possible.
It is necessary to consider that use of insufficient doses of drug or too early termination of treatment often leads to emergence of resistant strains of activators. At emergence of resistance it is necessary to continue treatment by other antibiotic.
Pregnancy and the period of a lactation
Use at pregnancy is possible if the expected advantage for mother exceeds potential risk for a fruit.
In need of use in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination (gets into breast milk in low concentration).
The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
does not influence.

Overdose
Symptoms: spasms, consciousness disturbance.
Treatment: drug withdrawal, symptomatic therapy (includes a hemodialysis, it is necessary to pay peritoneal dialysis, special attention water electrolytically to balance).

A form of release and packing
Powder for preparation of solution for intravenous and intramuscular administration of 1000000
Units 1000000 PIECES of active agent in bottles glass with a capacity of 10 ml, hermetically corked by rubber bungs, pressed out by caps aluminum or pressed out by the aluminum caps combined.
50 bottles with drug with application of equal number of instructions for use in the state and Russian languages place in group packing – in a box with partitions from cardboard.

To Store storage conditions in the dry place at a temperature not above 20 °C.
To store out of children’s reach!

3 years
not to apply a period of storage after an expiration date.

Prescription status
According to the prescription

JSC Biosintez Producer,
Russian Federation 440033, Penza, Druzhby St., 4, ph. / fax (8412) 57-72-49
e-mail: certificate@biosintez.com

the Name and the country of the owner of the registration certificate
of JSC Biosintez, the Russian Federation

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
of JSC Biosintez,
Russian Federation 440033, Penza, Druzhby St., 4, ph. / fax (8412) 57-72-49
e-mail:

To Develop certificate@biosintez.com

Additional information

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