Aktitsil 30g of cream in a tube

  • $8.50
Sku: dfafd3951a80

the Trade name

Mezhdunarodnoye the unlicensed name
Is not present

the Dosage form

30 g of cream contain
active agents: silver of Sulfadiazinum of 0.3 g
chlorhexidina gluconate of 0.15 g,
excipients: cetostearyl alcohol, tsetomakrogol 1000, light liquid paraffin, hydroxytoluene bottled, sodium hydrophosphate, methylparaben, propylparaben, the disodium EDTA salt, water purified.

The description
the Uniform cream of white color free from solid particles.

Pharmacotherapeutic group
Antimicrobial drugs for topical administration. Silver Sulfadiazinum in a combination with other drugs.
The code of automatic telephone exchange D06BA51

the Pharmacological

Pharmacokinetics At properties topical administration of Aktitsil cream active agents are practically not exposed to system absorption.

A pharmacodynamics
the Combined antimicrobial drug for external use. Effect of drug is caused by properties of the components which are its part.
When drawing to a burn surface cream Aktitsil active agent - Sulfadiazinum of silver breaks up, slowly and continuously releasing ions of silver and streptocide that provides inhibition of growth and reproduction of bacterial cells. Sulfadiazinum of silver possesses a wide range of the antibacterial activity including actually all species of the microbes causing infection of burn and other wounds on the surface of skin (including Pseudomonas aeruginosa, Escherichia coli, Proteus spp., Staphylococcus spp., Streptococcus spp., Klebsiella spp., Enterobacter spp.) and also barmy mushrooms (Candida albicans) and some virus strains of herpes. Sulfadiazinum of silver gets into nekrotizirovanny fabrics and exudate.
The second active ingredient of Aktitsil cream - chlorhexidin is an antiseptic agent of a broad spectrum of activity, possesses bactericidal action. It is active concerning vegetative forms of gram-negative and gram-positive microorganisms and also yeast, dermatophytes and lipophilic viruses.

Infectious and inflammatory diseases of skin:
- treatment and prevention of burn infections (including before carrying out an autodermoplastika)
- treatment of purulent wounds, treatment and prevention of infection of trophic ulcers and cuts
the Route of administration and doses
Aktitsil can be applied with use of bandages or without them. Drug is intended only for drawing on skin.
After surgical treatment of a surface of a burn, cream is applied on it with a layer 2-4 mm thick. Drug should be applied 1-2 times a day.
Treatment should be continued before full healing of a wound surface.
The route of administration of cream is identical to treatment of burns and trophic ulcers. Bandages should be changed daily.
Side effects
– burning sensation, itching
Isolated cases:
- skin necrosis, a mnogoformny erythema, xanthopathy disturbances, interstitial nephrite
When putting cream on extensive wound and burn surfaces the development of the side reactions characteristic of systemic action of streptocides is in rare instances possible: a leukopenia, an agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia, skin allergic reactions (including Stephens-Johnson's syndrome and exfoliative dermatitis), the dispeptic phenomena, hepatitis, hepatocellular necrosis, reactions from the central nervous system, a toxic nephrosis.

- children's age up to 2 months, including premature newborn children
- the individual intolerance of streptocides, a chlorhexidina and also other components of drug

Medicinal interactions
Drug can inactivate effect of fermental drugs for clarification of a wound at their simultaneous use.
It is noted that at simultaneous use of Cimetidinum the risk of development of a leukopenia increases.

Special instructions
With care patients should appoint drug with hypersensitivity to streptocides because of a possibility of development of cross sensitivity.
As well as at use of other local antimicrobial drugs, at treatment Aktitsil cream development of superinfection is possible.
With care to apply at patients with congenital insufficiency glyukozo-6-fosfatdegidrogenazy because of risk of development of hemolysis.
When drawing Aktitsil's on burn wounds of the big area the concentration of Sulfadiazinum in serum can reach level therapeutic at intake. In this case control of concentration of Sulfadiazinum in serum, control of function of kidneys and also control of possible content of Sulfadiazinum in urine is necessary.
At prolonged use of Aktitsil on the big surface of skin it is necessary to control a blood count because of possible development of a leukopenia, thrombocytopenia or an eosinophilia.
With care to appoint drug to patients with disturbances of functions of a liver and kidneys because of possible cumulation of drug owing to the slowed-down removal. It is necessary to resolve an issue of expediency of continuation of therapy, considering possible consequences of its cancellation and advantage at continuation. In case of continuation of treatment it is necessary to control concentration of Sulfadiazinum in serum.
Drug should not be used at a porphyria.
Not to allow hit of cream in eyes.
Pregnancy and the period of a lactation
Use of drug increases risk of development of a hyperbilirubinemia therefore it is not necessary to appoint Aktitsil at pregnancy, especially in the III trimester of pregnancy and during childbirth. The exception is made by cases when the potential advantage for preservation of life of the patient exceeds the existing risk for a fruit.
It is unknown whether drug with breast milk at the person is emitted. However other streptocides in milk are found. Besides, all streptocides increase risk of development of a hyperbilirubinemia. Due to a possibility of development of serious side effects in the baby at use of streptocides by the nursing mother, in case of need uses of drug in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination, considering at the same time degree of the importance of treatment for mother.
Influence on ability to run the vehicle and/or potentially dangerous mechanisms
does not influence.

Symptoms: strengthening of side reactions of drug. Argiriya in connection with the increased system absorption of silver does not develop.
Treatment: symptomatic therapy, plentiful drink (it is recommended to support a daily urine at the level of 1200-1500 ml and more).

A form of release and packing
On 30 g of drug in an aluminum tube with control of the first opening, corked by the polyethylene screwed cap. One tuba together with instructions for use in the state and Russian languages is placed in a cardboard box.

To Store storage conditions in the dry, protected from light place at a temperature not higher than 25 wasps. Not to freeze.
To store out of children's reach!

3 years
not to apply a period of storage after an expiration date!

Prescription status
Without prescription

of Proizvoditel Akriti Pharmasyyutikalz Pvt. Ltd.
117, Block 2, Emerald Plaza, Hiranadani Meadows Thane West, 400,610, India

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
Almaty, Dzhangildin St., 31, office 416
Ph./fax: (727) 278 59 20, (727) 278 59 21
e-mail: reg@avitsena.kz
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