Triplixam® (Perindopril, Amlodipine, Indapamide) 30 tablets

What is Triplixam®?

Triplixam® is a combination medication used to treat essential hypertension (high blood pressure).

This medication contains three active ingredients: Perindopril, Amlodipine, and Indapamide.

Each component works together to help lower blood pressure effectively, making it easier for the heart to pump blood and reduce the risk of cardiovascular complications.

What are the Available Dosages and Forms of Triplixam®?

Triplixam® is available in film-coated tablets with the following dosage combinations:

• 5 mg/1.25 mg/5 mg
• 5 mg/1.25 mg/10 mg
• 10 mg/2.5 mg/5 mg
• 10 mg/2.5 mg/10 mg

These dosage variations allow healthcare providers to tailor the treatment to the specific needs of the patient.

How Does Triplixam® Work?

Triplixam® combines three active substances, each contributing to the overall effect of lowering blood pressure:

• Perindopril: An ACE inhibitor that helps relax blood vessels.
• Amlodipine: A calcium channel blocker that prevents calcium from entering the heart and blood vessel cells, which helps to lower blood pressure.
• Indapamide: A diuretic that helps reduce the amount of fluid in the blood, decreasing blood pressure.

When Should You Use Triplixam®?

Triplixam® is prescribed to patients with essential hypertension who have already achieved adequate control with the combination of Perindopril and Indapamide in fixed doses, plus Amlodipine, in the same doses as found in Triplixam®. It is intended as a replacement therapy to streamline the treatment process.

What Precautions Should Be Taken Before Using Triplixam®?

Before starting Triplixam®, it is essential to be aware of certain contraindications and precautions:

Contraindications:

• Hypersensitivity to any of the active substances or excipients in the medication.
• History of angioedema related to previous ACE inhibitor therapy.
• Severe renal impairment or significant liver dysfunction.
• Pregnancy and lactation.

Precautions:

• Kidney Function: Patients with impaired kidney function should be closely monitored, especially at the beginning of treatment.
• Potassium Levels: Use caution with medications or conditions that can raise potassium levels, as this can lead to serious heart issues.
• Elderly Patients: Dose adjustments may be necessary based on kidney function and blood pressure response.

What Should You Discuss with Your Doctor Before Taking Triplixam®?

Before taking Triplixam®, inform your healthcare provider if you have any of the following conditions:

• A history of allergic reactions, especially to penicillin or sulfonamides.
• Vision changes or eye pain, as these could be signs of serious eye problems that may occur with Triplixam®.
• Any planned surgical procedures, as ACE inhibitors may cause complications under anesthesia.

How Should Triplixam® Be Stored?

Store Triplixam® in a tightly closed container at a temperature not exceeding 30°C (86°F).

Keep it out of reach of children to prevent accidental ingestion.

The medication should not be used beyond its expiration date.

What are the Possible Side Effects of Triplixam®?

Like all medications, Triplixam® may cause side effects.

Common side effects include dizziness, headache, and swelling in the ankles.

In rare cases, more serious side effects like angioedema (severe swelling under the skin) or significant changes in kidney function may occur.

If you experience any severe side effects, contact your healthcare provider immediately.