Chymotrypsin crystalline 0.01g 10s lyophilized powder for injection

  • $32.70
Sku: b657166e47c8
Ingredient: Chymotrypsin
The instruction for medical use
of medicine
Chymotrypsin crystal

the Trade name
Chymotrypsin crystal

the International unlicensed

name Chymotrypsin Dosage Form Lyophilisate for preparation of solution for injections on 0:01 g

One ampoule contains
active agent – chymotrypsin of 0.01 g

the Description
the Porous mass or powder of flavourless white color. It is hygroscopic.

Pharmacotherapeutic group
Drugs for treatment of wounds and cankers. Fermental drugs. Proteolytic enzymes.
The ATX D03BA code

the Pharmacological

Pharmacokinetics Not properties it was investigated.
The pharmacodynamics
the Proteolytic enzyme received from pancreases of cattle hydrolyzes proteins and peptones with formation of rather low-molecular peptides. During hydrolysis the bonds formed by residues of tyrosine, phenylalanine and other aromatic amino acids are split mainly. Splits peptide bonds in a molecule of protein and products of its disintegration. Thanks to this mechanism possesses anti-inflammatory action as factors of inflammation represent proteins or high-molecular peptides (bradykinin, serotonin, necrotic products, etc.). Lyses nekrotizirovanny fabrics, without having effect on viable cells owing to existence in them of specific antienzymes.

- tracheitis, bronchitis, a bronchoectatic disease, pneumonia, abscess
of lungs, an atelectasis, bronchial asthma with hypersecretion
- prevention of complications after lung surgery
- burns, decubituses, purulent wounds
- thrombophlebitis
- purulent sinusitis, acute and subacute purulent average otitis,
an eustachitis with viscous exudate
- extensive thrombosis of the central vein of a retina, acute impassability
of the central artery of a retina, an opacity of the vitreous body travmati-
chesky and inflammatory origin, extraction of a cataract

the Route of administration and doses
the Route of administration and doses are established by the doctor individually for each patient.
When using novocaine as solvent, before use of drug it is necessary to carry out allergy test on novocaine. In diseases of respiratory organs (tracheitis, bronchitis, bronkhoektati-
a chesky disease, pneumonia, abscess of lungs, an atelectasis, bronchial asthma
with hypersecretion of a phlegm) drug is used intramusculary
in doses on 5-10 mg a day within 10-12 days. Further the course of treatment
can be repeated in 7-10 days. At the chronic, far come processes it is possible to repeat a course of treatment 3-4 times.
In the postoperative period (at the appeared atelectasis, or the beginning pneumonia) drug is appointed intramusculary on 5-10 mg (in 1-3 ml of 0.25% of solution of novocaine) in day. At the same time it is recommended to combine administration of chymotrypsin intramusculary with vagosympathetic blockade on the party of defeat according to Vishnevsky and use of chymotrypsin in the form of aerosol inhalations in 5% aqueous solution in number of 3-4 ml.
At a hemothorax, an empyema chymotrypsin is entered daily inside-plevralno on 20-30 mg (to dissolve in 5-10 ml 0.9% of solution of sodium of chloride or 0.25% of novocaine).
For the purpose of prevention of postoperative complications (
lung surgery) the drug is administered intramusculary on 5-10 mg daily, beginning
in 5-10 days prior to operation and continuing within 3-4 days after it.
At treatment of burns and decubituses after removal of freely removed
necrotic fabrics chymotrypsin in a dose of 20 mg dissolve 0.25%
of solution of novocaine in 20 ml and a fine needle several pricks enter under a scab.
It is desirable to make before introduction notches on a scab. At the next
bandaging, lizirovanny necrotic fabrics need to be deleted furs -
In thrombophlebitises drug is appointed intramusculary on 5-10 mg
daily by 7-10 days. In case of inefficiency of the first course of treatment
the repeated courses are not reasonable.
For treatment of purulent wounds the intramuscular administrations of drug combine
with topical treatment of a wound the tampons moistened 5% with solution khimo-
trypsin (prepares for 0.9% of solution of sodium of chloride).
In purulent sinusitis the drug is administered in an antrum of Highmore in number of 5-10 mg in 3-5 ml of normal saline solution after its puncture and washing.
In otitises dig in in an ear on 0.5 - 1 ml 0.1% of solution of chymotrypsin,
prepared on normal saline solution.
At treatment of thromboses of the central vein of a retina, acute impassability of the central artery of a retina chymotrypsin apply in the form of 5% rast
the thief for 1% novocaine solution. To enter podkonjyunktivalno 0.2 ml
1-2 times a week.
At extraction of a cataract chymotrypsin in cultivation 1: 5000 enter into a back chamber of the eye with the subsequent washing of an anterior chamber normal saline solution in 4 minutes after administration of drug.

Side effects
- tachycardia
- irritation and puffiness of a conjunctiva, at emergence it is necessary to reduce
concentration of solution of drug or to stop its use
- pain and hyperaemia in the place of an injection
- a hyperthermia, feeling of an itching, skin rashes, a small tortoiseshell, zatrud-
nenny breath
- fervescence to subfebrile
is rare
- irritation of a mucous membrane of upper airways, the hoarseness
disappearing without any treatment (after inhalation
by chymotrypsin)

- hypersensitivity to drug or products of proteolysis
- hypersensitivity to novocaine (at use of novocaine
as solvent)
- chronic heart failure of the II-III degree
- emphysema of lungs with insufficiency of breath
- dekompensirovanny forms of a pulmonary tuberculosis
- dystrophy and cirrhosis
- infectious hepatitis
- pancreatitis
- nephrite
- hemorrhagic diathesis
- malignant new growths
- children's and teenage age up to 18 years
- pregnancy and the period of a lactation
do not enter Chymotrypsin into the centers of inflammation and the bleeding wounds and cavities, do not apply on the expressed surfaces of malignant new growths.

Medicinal interactions
Chymotrypsin can be applied in a combination with antibiotics and
bronchodilatory means.

The special
instructions Apply Crystal Chymotrypsin at treatment of diseases of airways at patients with active ostroprotekayushchy tubercular process follows with care in view of development of the significant temperature histamine-like reaction. Administration of antihistaminic drugs before chymotrypsin use, removal of necrotic fabrics after impact of drug on them (expectoration or suction of a phlegm, washing of wounds, etc.) is recommended with the preventive purpose.
Drug should be used with care to patients with an empyema of a pleura of a tubercular etiology as resorption of exudate can
lead ment of a bronchopleural fistula.
Use during pregnancy or a lactation
was not studied.
The children's age
Experience of use for children is limited.
Features of influence of medicine on ability to run
the vehicle or potentially dangerous mechanisms.
It is necessary to be careful at control of motor transport or
other potentially dangerous mechanisms.

In view of hypotoxicity of overdoses it was not noted.

A form of release and packing
On 0:01 g of drug in ampoules glass or ampoules glass with a break ring.
On 10 ampoules of drug together with the instruction for medical use in the state and Russian languages and the disk cutting ceramic for opening of ampoules (if necessary) put in a pack from cardboard bandbox (chrome ersatz) with partitions or a corrugated tab, or with a polymeric tab from a film polyvinylchloride for placement and fixing of ampoules.

To Store storage conditions in the dry, protected from light place, at a temperature from 2 ºС
to 8 ºС
to Store out of children's reach!

The period of storage

not to use 3 years Drug after an expiration date.

Prescription status
According to the prescription

CIAO Producer of Biopharm, Ukraine
Address: 03680, Kiev, N. Amosova St., 9, Ukraine, ph. (+38-044)-275-16-04, 275-91-50, 521-15-39

The owner of the registration certificate
of LLC Federal Law Biopharm, Ukraine

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality produktsiiip G.S. Tleubergenov 010000, Akmola Region Astana, Bozingen St.
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