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Kestin 10s 20 mg coated tablets




The instruction for medical use

of KESTIN® medicine

the Trade name
of Kestin®

the International unlicensed

name Ebastin Lekarstvennaya
the Tablet form, coated 10 mg, 20 mg

One tablet contains
active agent – ebastin 10 mg or 20 mg,
excipients: microcrystalline cellulose, starch corn pre-gelated, lactose monohydrate, croscarmellose sodium, magnesium stearate,
structure of a cover: hydroksipropilmetiltsellyuloza, polyethyleneglycol 6000, titan dioxide.

of the Tablet of 10 mg: tablets of round shape, film coated, white color. On one party of tablets there is an engraving E 10 and risk.
Tablets of 20 mg: tablets of round shape, film coated, white color. On one party of tablets there is an engraving E 20

Pharmacotherapeutic group
Other antihistaminic drugs for system use.
The code of automatic telephone exchange R06AX22

the Pharmacological

Pharmacokinetics Later properties of intake is quickly soaked up and is almost completely metabolized in a liver, turning into an active metabolite karebastin. After single dose of 5 or 10 mg of drug the maximum concentration of a karebastin in plasma is reached in 2.8-3.4 h and makes 108-209 ng/ml, 10 mg of tablets – 2.6-4 hours and 80-100 ng/ml respectively. Greasy food accelerates absorption (concentration in blood increases up to 50%). It is removed by kidneys – 60-70%, in the form of conjugates. Elimination half-life normal makes 15-19 hours. In a renal failure the elimination half-life increases up to 23-26 h, in a liver failure – up to 27 h. Does not get through a blood-brain barrier.
At daily reception of 10 mg of drug the equilibrium concentration is reached in 3-5 days and makes 130 – 160 ng/ml. linking with proteins of plasma of an ebastin and karebastin makes more than 95%. Elimination half-life of a karebastin makes from 15 to 19 hours, 66% of drug are removed in the form of conjugates with urine.
When prescribing drug along with meal the concentration of a karebastin increases in blood by 1.6 – 2 times, however it does not lead to change of time of achievement of its maximum concentration and does not influence clinical effects of Kestina®.
At patients of advanced age the pharmacokinetic indicators significantly do not change. In a renal failure the elimination half-life increases till 23 – 26 o’clock, and in a liver failure – till 27 o’clock, however concentration of drug at reception of 10 mg/days does not exceed therapeutic values.
The pharmacodynamics
After administration of drug inside antiallergic action begins in 1 h and lasts for 48 h. After a 5-day course of treatment of Kestinom® the antihistaminic activity remains during 72 h due to action of active metabolites. Drug does not render expressed anticholinergic and sedation. Influence of Kestina® on QT ECG interval when assigning in a dose to 80 mg is noted.

– allergic rhinitis seasonal and/or year-round (caused by household, pollen, epidermal, food-borne, medicinal allergens)
– the small tortoiseshell (called by household, pollen, epidermal, food-borne, insektny, medicinal allergens, influence of the sun, cold, etc.)
– the allergic diseases and states caused by the increased release of a histamine.

The route of administration and doses
to Adults and children are more senior than 15 years appoint 10-20 mg (1-2 tablets) once a day.
To children from 12 to 15 years appoint 10 mg once a day.
To children from 6 to 12 years appoint 5 mg once a day.
Кестин® accept irrespective of meal.

Side effects
– a headache
– dryness in a mouth
– dyspepsia, nausea
– insomnia, drowsiness
– an asthenic syndrome.

– hypersensitivity to drug
– pregnancy, the breastfeeding period
– with care at liver and/or a renal failure
– tablets, 20 mg are not intended for reception at children up to 15 years
– tablets, 10 mg are not intended for reception at children up to 6 years

Medicinal interactions
it is not recommended to appoint Kestin® along with ketokonazoly and erythromycin.
Кестин® does not interact with theophylline, indirect anticoagulants, Cimetidinum, diazepam, ethanol and etanolsoderzhashchy drugs.

Special instructions
In an abnormal liver function the daily dose should not exceed 10 mg. With care to apply at patients, with the increased QT – an interval, a hypopotassemia.
The feature of influence of medicine on ability to run the vehicle or potentially dangerous
Kestin mechanisms in therapeutic doses does not affect ability to run vehicles and mechanisms.

Symptoms: strengthening of side effects.
Treatment: special antidote for drug does not exist. In case of overdose the gastric lavage, observation of the vital functions of an organism is recommended. Symptomatic treatment.

A form of release and packing
On 10 tablets in blister strip packaging from a film of polyvinylchloride and aluminum foil. On 1 packing together with the instruction for use in the state and Russian languages put in a cardboard pack.

To Store storage conditions at a temperature not above 30 °C in the place protected from light.
To store out of children’s reach!

3 years
not to use a period of storage after expiry date.

Prescription status
According to the prescription

the Producer Nikomed Denmark by the FPÖ Denmark, it is made: S.L. Indastrias Pharmasyyutikas Almiral, Spain.

The address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
of Nikomed Ostevropa Marketing Service GmbH
Almaty, Begalin St. 136 and
Phone number (727) 2444004
Fax number (727) 2444005
E-mail address of

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