The instruction for medical use of medicine of Vitaprost® Plus Torgovoye nazvaniye Vitaprost® Plus the International unlicensed name Is not present the Dosage form Suppositories rectal 20 mg / 400 mg Structure One suppository contains active agent - prostates extract – 100 mg (in terms of water-soluble peptides – 20 mg), a lomefloksatsina a hydrochloride – 400 mg, excipient: fat firm (Vitepsol (brand H 15, W 35), Supposir (brands NA 15, NAS 50)) – enough before receiving a suppository weighing 2.25 g. The description Suppositories from color, white or almost white to light-cream with a grayish shade, a torpedo-shaped form. Emergence of a white plaque on a suppository surface is allowed. The pharmacotherapeutic group Other drugs for treatment of urological diseases the ATX G04BX Code the Pharmacological The Combined Drug of Vitaprost® Plus properties has antimicrobic and anti-inflammatory properties. Lomefloksatsin – microbicide of a broad spectrum of activity from group of ftorkhinolon. Influences bacterial DNK-girazu enzyme, the providing superspiralling, forms a complex with its tetramer (A2B2 giraza subunits) and breaks a transcription and DNA replication, leads to death of a microbic cell. It is highly active concerning gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitides, Escherichia coli, Citrobacter diversus, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella morganii, Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila, Pseudomonas aeruginosa. Are moderately sensitive to the drug Staphylococcus aureus, Staphylococcus epidermidis, Serratia liquifaciens, Serratia marcescens, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia alvei, Citrobacter freundii, Aeromonas hydrophila, Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Providencia alcalifaciens, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans. Also anaerobic bacteria are resistant to the drug Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pallidum, Mycoplasma hominis. Affects the majority of microorganisms in low concentration (the concentration necessary for suppression of height of 90% of strains, usually no more than 1 mkg/ml). The resistance develops seldom. Extract of a prostate possesses organotropic action on a prostate. Reduces degree of hypostasis, leukocytic infiltration of a prostate, normalizes secretory function of epithelial cells, increases number of lecithin grains in a secret of an acinus, stimulates a muscle tone of a bladder. Improves microcirculation in a prostate due to reduction of a thrombogenesis, antiagregantny activity, interferes with development of thrombosis of venules in a prostate. Vitaprost® Plus normalizes function of a prostate and structure of an ejaculate. Reduces the pain and discomfort caused by prostatitis, improves copulative function. Indications - the acute and chronic bacterial prostatitis caused by sensitive microorganisms, including which is followed by inflammatory diseases of an urinogenital path - a state before surgeries on a prostate the Route of administration and Rektalno's doses, on 1 suppository once a day, after independent bowel emptying or a cleansing enema. Before use the suppository should be taken from blister strip packaging. After introduction of a suppository, stay of the patient in a bed within 30-40 minutes is desirable. The course of treatment proceeds before disappearance of the activator in secretion of a prostate and makes from 10 to 30 days (duration of treatment is determined by the attending physician individually for each patient). Side effects - allergic reactions (skin itching, a small tortoiseshell, a photosensitization, a malignant exudative erythema (Stephen-Johnson's syndrome)) - an asthenia, dizziness, nervousness, uneasiness, fatigue, an indisposition, a headache, unconscious states, insomnia, hallucinations, spasms, hyperkinesias, a tremor, paresthesias, a depression, excitement - a pseudomembranous coloenteritis, dysbacteriosis, dryness of a mucous membrane of an oral cavity, diarrhea or a constipation, a meteorism, discoloration of language, a loss of appetite or bulimia, a food faddism, increase in activity of hepatic transaminases - bleedings from bodies of digestive tract, thrombocytopenia, increase in a fibrinolysis, a limfoadenopatiya, a purpura, nasal bleeding - a lowering of arterial pressure, tachycardia, bradycardia, premature ventricular contraction, arrhythmias, progressing of heart failure and stenocardia, a pulmonary embolism, a cardiomyopathy, phlebitis - a glomerulonephritis, a dysuria, a polyuria, an anury, an albuminuria, urethral bleedings, a crystalluria, a hamaturia, an ischuria, swell - an orchitis, an epididymite - a hypoglycemia, gout - an arthralgia, a vasculitis, spasms of gastrocnemius muscles, ruptures of sinews at elderly patients, especially in combination with glucocorticoids, dorsodynias and breasts - short wind, a bronchospasm, cough, phlegm hypersecretion, grippopodobny symptoms - a disorder of vision, pain and sonitus, eye pain - sweating strengthening, a fever, thirst, Contraindication superinfection - hypersensitivity to drug components - the children's and teenage age up to 18 years Medicinal interactions of Vitaprost® Plus increases activity of oral anticoagulants and increases toxicity of non-steroidal anti-inflammatory drugs. The medicines blocking canalicular secretion slow down drug removal. There is no cross stability with penicillin, cephalosporins, aminoglycosides, co-trimoxazole, metronidazole. Vitaprost® Plus should appoint special instructions with care at the following states: - cerebral atherosclerosis - epilepsy and other diseases of the central nervous system with a convulsive syndrome. During drug treatment of Vitaprost® Plus it is necessary to limit simultaneous use of antimicrobial means – ftorkhinolon in order to avoid development of overdose and increase in frequency of side effects. In cirrhosis the correction of the mode of dosing is not required (on condition of normal function of kidneys). During treatment it is necessary to avoid long impact of sunlight and use of artificial ultra-violet lighting. At the first signs of a photosensitization (increase in sensitivity of skin, a burn, hyperaemia, hypostasis, emergence of blisters, rashes, an itching, dermatitis), hypersensitivity, manifestations of neurotoxicity (excitement, spasms, a tremor, a photophobia, confusion of consciousness, toxic psychoses, hallucinations) it is necessary to stop therapy. The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms during treatment needs to be careful when driving or potentially dangerous mechanisms. The overdose is not revealed the Form of release and packing On 5 suppositories place in blister strip packaging from a film polyvinylchloride, laminated by polyethylene. On 2 planimetric packs together with the instruction for medical use in the state and Russian languages put in a pack from cardboard. To Store storage conditions at a temperature not over 25 ºС. To store out of children's reach! 2 years not to apply a period of storage after an expiration date. Prescription status Without prescription the Producer / Packer of JSC Nizhpharm, Russian Federation 603950, Nizhny Novgorod, Salganskaya St., 7 ph.: (831) 278-80-88 fax: (831) 430-72-28 e-mail: med@stada.ru the Name and the country of the owner of the registration certificate of JSC Nizhpharm, the Russian Federation the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) and responsible for post-registration observation of safety of medicine Representative office of JSC Nizhpharm 050043, Republic of Kazakhstan, Almaty, mdt. Khan-Taniri, 55b ph.: (727) 2222-100 fax: (727) 398-64-95 e-mail: almaty@stada.kz
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