Travatan 40 ug / ml 2.5 ml of eye drops
- $41.80
The instruction for medical use
of Travatan® medicine
the Trade name
of Travatan®
the International unlicensed
name Travoprost Lekarstvennaya
the Drop form eye 40mikrogramm/ml 2.5 ml
Structure
of 1 ml contains
active agent: travoprost 40 mkg.
excipients: chloride a benzalkoniya, Mannitolum, trometamol, the hydrogenated polyoxyethylene of castor oil 40 (HCO – 40), boric acid, edetat dinatrium, sodium hydroxide and/or Acidum hydrochloricum (for adjustment rn), purified water.
The description
Colourless to light yellow solution.
Pharmacotherapeutic group
Protivoglaukomny drugs others.
The code of automatic telephone exchange S01EX
the Pharmacological
Pharmacokinetics At properties topical administration of eye drops, Travoprost is systemically soaked up through a cornea. Travoprost it is quickly hydrolyzed by efiraza in a cornea cover to biologically active free acid. Systemically free acid of the travoprost is quickly and extensively metabolized to inactive metabolites. Biotransformations include beta oksidatsiyu α (carboxylic acid) of a chain, with formation of 1.2 diholes and 1,2,3,4 tetraholes of analogs, oxidation of a 15-hydroxyl component and also restoration 13, 14 double communications.
Free acid of the travoprost is defined in blood plasma only within the first hour after use of eye drops of Travatan®. Free acid of the travoprost and the formed metabolites generally are removed through bile, the rest is removed through kidneys. Two percent (2%) of a local dose of the travoprost are found in urine in the form of free acid.
The pharmacodynamics
of Travatan® is an analog of F2α prostaglandin, agonist which is highly selection and has high affinity with a receptor of FP prostaglandin and reduces intraocular pressure by increase in outflow of intraocular liquid through a tubular retina and a uvioskleralny path. Decrease in intraocular pressure begins approximately in 2 hours after burying, the maximum effect is reached in 12 hours. Considerable decrease in intraocular pressure can be observed within 24 hours when using a single dose.
Indications
- the increased intraocular pressure at patients with an open-angle form of glaucoma
- the raised intraocular tension
the Efficiency and safety of use of Travatana® for children is not established.
The route of administration and doses
of Travatan® dig in in a konyyuktivalny bag once a day in the evening on 1 drop in the affected eye (eyes).
After influence the closing of the lacrimonasal channel or careful closing of a century is recommended. It reduces system absorption of medicine and also reduces a system adverse effect.
It is not necessary to apply more than 1 drop of Travatana® a day as more frequent burying can reduce effect of decrease in intraocular pressure.
If the dose was passed, then treatment has to be continued with the following dose according to the schedule. The dose should not exceed 1 drop a day in the affected eye (eyes).
When replacing other protivoglaukomny drug, eye drops of Travatan®, it is necessary to stop intake of the replaced drug and to begin reception of Travatana® next day. When using several ophthalmologic drugs of topical administration, it is necessary to observe an interval between burying at least 5 minutes.
It is not necessary to touch with a pipette tip eyes, or any other surface to avoid pollution of contents of a bottle.
Safety and efficiency of eye drops of Travatan® at use for patients was not younger than 18 years is established thereof use of drug before achievement of 18 years is not recommended.
Side effects
Local:
- irritation of an eye
- a keratitis
- hyperaemia
- rush of blood in an anterior chamber
- eye pain
- visual discomfort
- decrease in visual acuity
- misting of sight
- the xerophthalmus
- allergic konyyuktivit
- lachrymation
- puffiness of an eye
- bleeding of a conjunctiva
- pigmentation of a cornea
- irritation of a century
- an erythema of a century
- dermatitis of a century
- an asthenopia
- growth of eyelashes
- photophobia
System:
At absorption in rare instances can be noted
- from a cardiovascular system: disturbance of a warm rhythm, increase in arterial blood pressure, decrease in heart rate, a lowering of arterial pressure, thorax pain, an asthenia
- from central nervous system: a headache, dizziness, nervousness, a depression
- from a respiratory system: a spasm of bronchial tubes, bronchitis, sinusitis
- from an urinogenital system: dysfunction of a prostate, incontinence of urine and irritation of urinary tract
- from skin and hypodermic fabrics: discoloration of an iris, a skin hyperpegmentation around eyes, contact dermatitis
of the Contraindication
- hypersensitivity to any component of drug
- pregnancy
- a lactation
of Travatan® has to be used with care at patients with active intraocular inflammation (iritis/uveitis), at patients with a rupture of the back capsule is a lens or the anterior chamber of a lens, at patients having risk of developing of a macular cyst and at having high risk of developing an iritis/uveitis.
Medicinal interactions
Interaction of Travatana® with other medicines is not established definitely. Траватан® it can be applied together with other local ophthalmologic drugs to decrease in intraocular pressure. When using several drugs it is necessary to observe an interval between burying, at least, 5 minutes.
Special instructions
Influence on eyes
of Travoprost can change considerably color of an eye owing to increase in number of melonosom (pigmentary granules) in melanocytes.
Prior to treatment, the patient has to be informed on continuous discoloration of an eye. As a result of unilateral treatment the irreversible geterokhromnost is observed. Discoloration of an iris of the eye happens slowly and can be not noticeable within several months and years.
Chloride a benzalkoniya as preservative which can cause decolouration of a soft contact lens contains contact lenses of Travatan®. It is necessary to avoid contact of drops of Travatan® with a soft contact lens.
The patient has to be instructed about removal of a contact lens before use of Travatana®. The lens can be placed back only in 15 minutes after burying drug.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
As well as in a case with other eye drops, after burying the temporary ambiguity of sight or other visual concerns is possible that it can negatively affect ability to drive the car or other potentially dangerous mechanisms. In this case it is necessary to wait some time before recovery of sight.
The overdose
At topical administration of drops of Travatan® a possibility of overdose is improbable. At overdose of Travatanom® the treatment has to be symptomatic. At hit in an eye of excess amount of drug it is necessary to wash out eyes plentiful amount of warm water.
The form of release and packing
Eye drops of Траватан® 40 mkg/ml 2.5 ml, are delivered in an oval bottle with a dropper the doser Drop-Tainer® and the twisting cover, in a package from the polyethylene laminated by a foil.
Each bottle together with the instruction for use is packed into a cardboard box.
To Store storage conditions in vertical position at a temperature from +20 to + 250C.
To store in places inaccessible for children!
Period of storage
3 years.
Not to apply after an expiration date.
An expiration date after the first opening - 4 weeks at a temperature from +20 to + 250C.
Prescription status
According to the prescription
the Producer S.A. Alkon-Kuvrer N.V. (S.A. Alcon-Couvreur N.V.)
B-2870 of Puurs, Belgium
of Travatan® medicine
the Trade name
of Travatan®
the International unlicensed
name Travoprost Lekarstvennaya
the Drop form eye 40mikrogramm/ml 2.5 ml
Structure
of 1 ml contains
active agent: travoprost 40 mkg.
excipients: chloride a benzalkoniya, Mannitolum, trometamol, the hydrogenated polyoxyethylene of castor oil 40 (HCO – 40), boric acid, edetat dinatrium, sodium hydroxide and/or Acidum hydrochloricum (for adjustment rn), purified water.
The description
Colourless to light yellow solution.
Pharmacotherapeutic group
Protivoglaukomny drugs others.
The code of automatic telephone exchange S01EX
the Pharmacological
Pharmacokinetics At properties topical administration of eye drops, Travoprost is systemically soaked up through a cornea. Travoprost it is quickly hydrolyzed by efiraza in a cornea cover to biologically active free acid. Systemically free acid of the travoprost is quickly and extensively metabolized to inactive metabolites. Biotransformations include beta oksidatsiyu α (carboxylic acid) of a chain, with formation of 1.2 diholes and 1,2,3,4 tetraholes of analogs, oxidation of a 15-hydroxyl component and also restoration 13, 14 double communications.
Free acid of the travoprost is defined in blood plasma only within the first hour after use of eye drops of Travatan®. Free acid of the travoprost and the formed metabolites generally are removed through bile, the rest is removed through kidneys. Two percent (2%) of a local dose of the travoprost are found in urine in the form of free acid.
The pharmacodynamics
of Travatan® is an analog of F2α prostaglandin, agonist which is highly selection and has high affinity with a receptor of FP prostaglandin and reduces intraocular pressure by increase in outflow of intraocular liquid through a tubular retina and a uvioskleralny path. Decrease in intraocular pressure begins approximately in 2 hours after burying, the maximum effect is reached in 12 hours. Considerable decrease in intraocular pressure can be observed within 24 hours when using a single dose.
Indications
- the increased intraocular pressure at patients with an open-angle form of glaucoma
- the raised intraocular tension
the Efficiency and safety of use of Travatana® for children is not established.
The route of administration and doses
of Travatan® dig in in a konyyuktivalny bag once a day in the evening on 1 drop in the affected eye (eyes).
After influence the closing of the lacrimonasal channel or careful closing of a century is recommended. It reduces system absorption of medicine and also reduces a system adverse effect.
It is not necessary to apply more than 1 drop of Travatana® a day as more frequent burying can reduce effect of decrease in intraocular pressure.
If the dose was passed, then treatment has to be continued with the following dose according to the schedule. The dose should not exceed 1 drop a day in the affected eye (eyes).
When replacing other protivoglaukomny drug, eye drops of Travatan®, it is necessary to stop intake of the replaced drug and to begin reception of Travatana® next day. When using several ophthalmologic drugs of topical administration, it is necessary to observe an interval between burying at least 5 minutes.
It is not necessary to touch with a pipette tip eyes, or any other surface to avoid pollution of contents of a bottle.
Safety and efficiency of eye drops of Travatan® at use for patients was not younger than 18 years is established thereof use of drug before achievement of 18 years is not recommended.
Side effects
Local:
- irritation of an eye
- a keratitis
- hyperaemia
- rush of blood in an anterior chamber
- eye pain
- visual discomfort
- decrease in visual acuity
- misting of sight
- the xerophthalmus
- allergic konyyuktivit
- lachrymation
- puffiness of an eye
- bleeding of a conjunctiva
- pigmentation of a cornea
- irritation of a century
- an erythema of a century
- dermatitis of a century
- an asthenopia
- growth of eyelashes
- photophobia
System:
At absorption in rare instances can be noted
- from a cardiovascular system: disturbance of a warm rhythm, increase in arterial blood pressure, decrease in heart rate, a lowering of arterial pressure, thorax pain, an asthenia
- from central nervous system: a headache, dizziness, nervousness, a depression
- from a respiratory system: a spasm of bronchial tubes, bronchitis, sinusitis
- from an urinogenital system: dysfunction of a prostate, incontinence of urine and irritation of urinary tract
- from skin and hypodermic fabrics: discoloration of an iris, a skin hyperpegmentation around eyes, contact dermatitis
of the Contraindication
- hypersensitivity to any component of drug
- pregnancy
- a lactation
of Travatan® has to be used with care at patients with active intraocular inflammation (iritis/uveitis), at patients with a rupture of the back capsule is a lens or the anterior chamber of a lens, at patients having risk of developing of a macular cyst and at having high risk of developing an iritis/uveitis.
Medicinal interactions
Interaction of Travatana® with other medicines is not established definitely. Траватан® it can be applied together with other local ophthalmologic drugs to decrease in intraocular pressure. When using several drugs it is necessary to observe an interval between burying, at least, 5 minutes.
Special instructions
Influence on eyes
of Travoprost can change considerably color of an eye owing to increase in number of melonosom (pigmentary granules) in melanocytes.
Prior to treatment, the patient has to be informed on continuous discoloration of an eye. As a result of unilateral treatment the irreversible geterokhromnost is observed. Discoloration of an iris of the eye happens slowly and can be not noticeable within several months and years.
Chloride a benzalkoniya as preservative which can cause decolouration of a soft contact lens contains contact lenses of Travatan®. It is necessary to avoid contact of drops of Travatan® with a soft contact lens.
The patient has to be instructed about removal of a contact lens before use of Travatana®. The lens can be placed back only in 15 minutes after burying drug.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
As well as in a case with other eye drops, after burying the temporary ambiguity of sight or other visual concerns is possible that it can negatively affect ability to drive the car or other potentially dangerous mechanisms. In this case it is necessary to wait some time before recovery of sight.
The overdose
At topical administration of drops of Travatan® a possibility of overdose is improbable. At overdose of Travatanom® the treatment has to be symptomatic. At hit in an eye of excess amount of drug it is necessary to wash out eyes plentiful amount of warm water.
The form of release and packing
Eye drops of Траватан® 40 mkg/ml 2.5 ml, are delivered in an oval bottle with a dropper the doser Drop-Tainer® and the twisting cover, in a package from the polyethylene laminated by a foil.
Each bottle together with the instruction for use is packed into a cardboard box.
To Store storage conditions in vertical position at a temperature from +20 to + 250C.
To store in places inaccessible for children!
Period of storage
3 years.
Not to apply after an expiration date.
An expiration date after the first opening - 4 weeks at a temperature from +20 to + 250C.
Prescription status
According to the prescription
the Producer S.A. Alkon-Kuvrer N.V. (S.A. Alcon-Couvreur N.V.)
B-2870 of Puurs, Belgium
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