The instruction for medical use
of TIOTRIAZOLIN medicine
the Trade name
Tiotriazolin
Mezhdunarodnoye the unlicensed name
Is not present
the Dosage form
of the Tablet of 200 mg
Structure
One tablet contains
active agent - a tiotriazolin, in terms of 100% substance of 200 mg,
excipients: potato starch, povidone, calcium stearate, cellulose microcrystalline, sugar powder
the Description
of the Tablet of white or almost white color, round shape with a flat surface, with a facet and risky
Pharmacotherapeutic group
Drugs for treatment of heart diseases. Other drugs for treatment of heart diseases. Other cardiotonic drugs.
ATX C01E B code.
Pharmacological
Pharmacokinetics properties. Relative biological availability of drug – 64.5%, the semi-absorption period – 0.28 h, semi-removal – 1.3 h, the maximum concentration in blood plasma is reached in 1.18 h, linking with blood proteins does not exceed 10%. In considerable concentration drug collects in tissues of heart, liver, spleen, rectum and kidneys, in insignificant quantity - in lungs and a small intestine. Tiotriazolin does not affect acidity of a stomach and is allocated, mainly, with kidneys.
Pharmacodynamics. The pharmacological effect of a tiotriazolin is caused by antiischemic, membrane stabilizing, antioxidant and immunomodulatory action.
Influence of drug is implemented due to strengthening of compensatory activation of anaerobic glycolysis and activation of processes of oxidation in a tricarbonic acid cycle with preservation of the ATP intracellular fund. Existence in structure of a molecule of a tiotriazolin of thiol of sulfur of which oxidation-reduction properties, and tertiary nitrogen which connects surplus of ions of hydrogen, causes activation of an antioxidant system are characteristic. Strong recovery properties of tiolny group cause reaction with active forms of oxygen and lipidic radicals. Reactivation of anti-radical enzymes – superoxide dismutases, catalases and glutathione peroxidases – prevents initiation of active forms of oxygen.
Influence of a tiotriazolin leads to slowing down of processes of oxidation of lipids in ischemic sites of a myocardium, to reduction of sensitivity of a myocardium to catecholamines, prevention of progressive oppression of sokratitelny function of heart, stabilization and reduction according to a zone of necrosis and ischemia of a myocardium. Improvement of rheological properties of blood is carried out due to activation of a fibrinolytic system. Improvement of processes of metabolism of a myocardium, the increase in its sokratitelny ability leading to normalization of a warm rhythm allows to recommend tiotriazolin for treatment of patients with various forms of coronary heart disease.
In parallel with use of drug in cardiology, considering its high hepatoprotective properties, tiotriazolin apply at treatment of diseases of a liver and other internals. Drug prevents destruction of hepatocytes, reduces extent of fat infiltration and spread of centrolobular necroses of a liver, promotes processes of reparative regeneration of hepatocytes, normalizes in them proteinaceous, carbohydrate, lipidic and pigmentary exchanges. Increases the speed of synthesis and biliation, normalizes its chemical composition.
Indications
as a part of complex treatment:
- coronary heart disease (stenocardia, a myocardial infarction, a postinfarction cardiosclerosis), cardiac arrhythmias
- chronic hepatitis of various etiology (including alcoholic hepatitis), cirrhosis
the Route of administration and doses
In an angina of exertion and rest, a myocardial infarction, a postinfarction cardiosclerosis – on 100-200 mg in 3-4 times a day for 20-30 days.
At disturbance of a warm rhythm – on 100-200 mg inside or under language 3 times a day.
In liver diseases usually adult appoint on 100-200 mg in 3-4 times a day for 20-30 days.
Duration of a course of treatment is defined by the doctor individually, depending on weight and dynamics of a course of the disease.
In case of need reception of a single dose of 100 mg take the drug in the corresponding dosage.
Side effects
Drug, as a rule, is well transferred.
Very seldom possible following side effects:
- naggers, a dermahemia, rash, urticaria, a Quincke's disease, an acute anaphylaxis
- dizzinesses, sonitus
- manifestations of the dispepsichesky phenomena - dryness in a mouth, nausea, vomiting, an abdominal distension
- short wind, suffocation
- fever, the general weakness.
During post-registration observation also reactions which communication with reception of a tiotriazolin is not proved were noted:
- arterial hypertension, tachycardia.
Contraindications
- hypersensitivity to a tiotriazolin and other components of drug
- a renal failure
- pregnancy and the period of a lactation
- children's and teenage age up to 18 years
- hereditary intolerance of fructose or malabsorption of glucose galactose
Medicinal interactions
Tiotriazolin as it is possible to use cardiotyre-tread drug in a combination with basic means of therapy of coronary heart disease. As hepatoprotective means, can be combined with purpose of traditional methods of treatment of hepatitis of the corresponding etiology.
The special
instructions Use during pregnancy or feeding by a breast.
Use of drug during pregnancy or feeding by a breast was not studied.
Children.
Experience of use of drug for children insufficient.
Ability to influence speed of response at control of motor transport or work with other mechanisms.
Does not influence.
Overdose
Symptoms: increase in urine of concentration of sodium and potassium.
Treatment: symptomatic therapy, drug withdrawal.
A form of release and packing
On 10 tablets in blister strip packaging from a film of polyvinylchloride and aluminum foil with the press varnished.
On 9 blister strip packagings together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.
To Store storage conditions in original packing, at a temperature not over 25 of 0C.
To store out of children's reach!
2 years
not to apply a period of storage after expiry date.
Prescription status
According to the prescription
Ukraine JSC Kiyevmedpreparat Producer, 01032, Kiev, Saksagansky St., 139.
The owner of the registration certificate
of JSC Kiyevmedpreparat
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products: Representative office of Arterium corporation in the Republic Kazakhstan050060, Almaty, Al-Farabi Avenue 97, 3 entrance, office 54 Ph. / fax: 8 (727) 315-82-09, 8 (727) 315-82-10, E-mail: office@arterium.kz
of TIOTRIAZOLIN medicine
the Trade name
Tiotriazolin
Mezhdunarodnoye the unlicensed name
Is not present
the Dosage form
of the Tablet of 200 mg
Structure
One tablet contains
active agent - a tiotriazolin, in terms of 100% substance of 200 mg,
excipients: potato starch, povidone, calcium stearate, cellulose microcrystalline, sugar powder
the Description
of the Tablet of white or almost white color, round shape with a flat surface, with a facet and risky
Pharmacotherapeutic group
Drugs for treatment of heart diseases. Other drugs for treatment of heart diseases. Other cardiotonic drugs.
ATX C01E B code.
Pharmacological
Pharmacokinetics properties. Relative biological availability of drug – 64.5%, the semi-absorption period – 0.28 h, semi-removal – 1.3 h, the maximum concentration in blood plasma is reached in 1.18 h, linking with blood proteins does not exceed 10%. In considerable concentration drug collects in tissues of heart, liver, spleen, rectum and kidneys, in insignificant quantity - in lungs and a small intestine. Tiotriazolin does not affect acidity of a stomach and is allocated, mainly, with kidneys.
Pharmacodynamics. The pharmacological effect of a tiotriazolin is caused by antiischemic, membrane stabilizing, antioxidant and immunomodulatory action.
Influence of drug is implemented due to strengthening of compensatory activation of anaerobic glycolysis and activation of processes of oxidation in a tricarbonic acid cycle with preservation of the ATP intracellular fund. Existence in structure of a molecule of a tiotriazolin of thiol of sulfur of which oxidation-reduction properties, and tertiary nitrogen which connects surplus of ions of hydrogen, causes activation of an antioxidant system are characteristic. Strong recovery properties of tiolny group cause reaction with active forms of oxygen and lipidic radicals. Reactivation of anti-radical enzymes – superoxide dismutases, catalases and glutathione peroxidases – prevents initiation of active forms of oxygen.
Influence of a tiotriazolin leads to slowing down of processes of oxidation of lipids in ischemic sites of a myocardium, to reduction of sensitivity of a myocardium to catecholamines, prevention of progressive oppression of sokratitelny function of heart, stabilization and reduction according to a zone of necrosis and ischemia of a myocardium. Improvement of rheological properties of blood is carried out due to activation of a fibrinolytic system. Improvement of processes of metabolism of a myocardium, the increase in its sokratitelny ability leading to normalization of a warm rhythm allows to recommend tiotriazolin for treatment of patients with various forms of coronary heart disease.
In parallel with use of drug in cardiology, considering its high hepatoprotective properties, tiotriazolin apply at treatment of diseases of a liver and other internals. Drug prevents destruction of hepatocytes, reduces extent of fat infiltration and spread of centrolobular necroses of a liver, promotes processes of reparative regeneration of hepatocytes, normalizes in them proteinaceous, carbohydrate, lipidic and pigmentary exchanges. Increases the speed of synthesis and biliation, normalizes its chemical composition.
Indications
as a part of complex treatment:
- coronary heart disease (stenocardia, a myocardial infarction, a postinfarction cardiosclerosis), cardiac arrhythmias
- chronic hepatitis of various etiology (including alcoholic hepatitis), cirrhosis
the Route of administration and doses
In an angina of exertion and rest, a myocardial infarction, a postinfarction cardiosclerosis – on 100-200 mg in 3-4 times a day for 20-30 days.
At disturbance of a warm rhythm – on 100-200 mg inside or under language 3 times a day.
In liver diseases usually adult appoint on 100-200 mg in 3-4 times a day for 20-30 days.
Duration of a course of treatment is defined by the doctor individually, depending on weight and dynamics of a course of the disease.
In case of need reception of a single dose of 100 mg take the drug in the corresponding dosage.
Side effects
Drug, as a rule, is well transferred.
Very seldom possible following side effects:
- naggers, a dermahemia, rash, urticaria, a Quincke's disease, an acute anaphylaxis
- dizzinesses, sonitus
- manifestations of the dispepsichesky phenomena - dryness in a mouth, nausea, vomiting, an abdominal distension
- short wind, suffocation
- fever, the general weakness.
During post-registration observation also reactions which communication with reception of a tiotriazolin is not proved were noted:
- arterial hypertension, tachycardia.
Contraindications
- hypersensitivity to a tiotriazolin and other components of drug
- a renal failure
- pregnancy and the period of a lactation
- children's and teenage age up to 18 years
- hereditary intolerance of fructose or malabsorption of glucose galactose
Medicinal interactions
Tiotriazolin as it is possible to use cardiotyre-tread drug in a combination with basic means of therapy of coronary heart disease. As hepatoprotective means, can be combined with purpose of traditional methods of treatment of hepatitis of the corresponding etiology.
The special
instructions Use during pregnancy or feeding by a breast.
Use of drug during pregnancy or feeding by a breast was not studied.
Children.
Experience of use of drug for children insufficient.
Ability to influence speed of response at control of motor transport or work with other mechanisms.
Does not influence.
Overdose
Symptoms: increase in urine of concentration of sodium and potassium.
Treatment: symptomatic therapy, drug withdrawal.
A form of release and packing
On 10 tablets in blister strip packaging from a film of polyvinylchloride and aluminum foil with the press varnished.
On 9 blister strip packagings together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.
To Store storage conditions in original packing, at a temperature not over 25 of 0C.
To store out of children's reach!
2 years
not to apply a period of storage after expiry date.
Prescription status
According to the prescription
Ukraine JSC Kiyevmedpreparat Producer, 01032, Kiev, Saksagansky St., 139.
The owner of the registration certificate
of JSC Kiyevmedpreparat
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products: Representative office of Arterium corporation in the Republic Kazakhstan050060, Almaty, Al-Farabi Avenue 97, 3 entrance, office 54 Ph. / fax: 8 (727) 315-82-09, 8 (727) 315-82-10, E-mail: office@arterium.kz
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