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Sintomitsina 10% 25g in tube liniment

  • $3.20
Sku: 4912f6e60985
Ingredient: Chloramphenicol
The instruction for medical use
of medicine
Linimentum Synthomycini


the Trade name
Linimentum Synthomycini

the International unlicensed






name Chloramphenicol Dosage Form Linimentum of 10% 25 G Structure of 100 G of Linimentum contain
active agent: D, L-Chloramphenicol (synthomycin) – 10.00 g,
excipients: castor oil, emulsifier No. 1, sorbic acid, sodium of a karmelloz, the water purified.

The description
Linimentum of color, white or white with a yellowish shade, with a slight characteristic smell.

Pharmacotherapeutic group
Other antibacterial drugs for topical administration. Chloramphenicol.
ATX D06AX02 code

Pharmacological

Pharmacokinetics At properties external use extent of system absorption insignificant.
The pharmacodynamics
Active ingredient of drug is chloramphenicol – the antibiotic of a broad spectrum of activity having antibacterial
activity concerning the causative agent of a wound fever and various forms of pyoinflammatory processes.
Chloramphenicol – a bacteriostatic antibiotic – breaks process of synthesis of protein in a microbic cell (having good lipophilicity, gets through a cellular membrane of bacteria and reversibly contacts a subunit 50S of bacterial ribosomes in which movement of amino acids to the growing peptide chains is delayed that leads to disturbance of synthesis of protein). It is active concerning the majority of strains of the gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, streptocides. Promotes clarification and healing of burn wounds and trophic ulcers, accelerates epithelization.

Indications
- wounds in the second phase of wound process (lack of pus, necrotic fabrics)
- it is long not healing trophic ulcers
- burns of the II-III degree

the Route of administration and doses
Outwardly: after surgical treatment of wounds and burns the drug Synthomycin linimentum of 10% is applied directly on a wound surface then apply a sterile gauze bandage (or to a dressing material, and then – to a wound). rykhlo fill with tampons with linimentum cavities of purulent wounds after their surgical treatment, and gauze turundas with the drug Synthomycin enter linimentum of 10% into the fistular courses.
At treatment of wounds and burns in the II phase of wound process to apply 1 time in 1-3 days depending on dynamics of healing of wounds.
Before use at children's age (from 4 weeks to 3 years) to consult with the doctor.

Side effects
For classification of undesirable consequences in terms of frequency the following classification is used: very often – 1/10, it is frequent – from 1/100 to 1/10, infrequently – from 1/1000 to 1/100, is rare – from 1/10000 to 1/1000, is very rare – & lt, 1/10000.
– allergic reactions (skin rash, a Quincke's disease),
- from bodies of a hemopoiesis: seldom the reticulocytopenia, thrombocytopenia, an erythropenia, aplastic anemia, a granulocytosis, a leukopenia, a granulocytopenia,

Contraindications
- individual intolerance
- pregnancy and a lactation
- oppression of a marrowy hemopoiesis
- a sharp intermittent porphyria
- deficit glyukozo-6-fosfatdegidrogenazy

- a liver and renal failure
- skin diseases (fungus diseases, psoriasis, eczema)
- the first phase of wound process (plentiful suppuration, the profound hypostasis of fabrics, pain and presence of necrotic fabrics)
- the neonatality period up to 4 weeks

Medicinal interactions
At simultaneous use with erythromycin, clindamycin, lincomycin is noted mutual weakening of action because chloramphenicol can force out these drugs from the connected state or interfere with their linking with a subunit of 5OS of bacterial ribosomes.
Reduces antibacterial effect of penicillin and cephalosporins.

Special instructions
In view of lack of osmotic activity (a basis – oil, emulsifier) are not recommended to be applied in the first phase of wound process (plentiful pus - a course, the profound hypostasis of fabrics, pain and presence of necrotic fabrics).
In the course of treatment the systematic control of a picture of peripheral blood is necessary. The patients receiving earlier treatment by cytostatic drugs or radiation therapy have to use drug with care.
Children's age

it is possible to Apply with care at children up to 3 years At a concomitant use of ethanol development of disulfiramovy reaction (hyperaemia of integuments, tachycardia, nausea, vomiting, reflex cough, spasms).
Features of influence of drug on ability to run motor transport or potentially dangerous mechanisms


the Overdose
of Cases of overdose of drug at topical administration does not influence it was not observed.

The form of release and packing
On 25 g of drug place in tubas aluminum about the bushonam with internal varnish coating and a membrane of control of opening corked by the screw-on plastic covers with a pin for a membrane puncture. On 1 tuba together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.


To Store storage conditions in the dry, protected from light place at a temperature not above 15 °C.
To store out of children's reach!

A period of storage
2 years
not to apply after an expiration date

Prescription status
Without prescription


CJSC Altayvitaminy Producer, the Russian Federation

Address: 659325, Altai Krai, Biysk, Zavodskaya St., 69 Phone numbers:
(3854) 326-946, 338-719 Fax: (3854) 327-640

The owner of the registration certificate
of CJSC Altayvitaminy, the Russian Federation

the Address of the organization accepting claims from consumers on quality of products (goods), the phone number, the fax number, the e-mail address
of CJSC Altayvitaminy


Address: 659325, Russian Federation, Altai Krai, Biysk, Zavodskaya St., 69 Phone numbers:
(3854) 326-946, 338-719 Fax: (3854) 327-640
E-mail: office@altayvitamin.ru
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