Nolgripp (100 tablets)

  • $31.10
Sku: 1e4165dd2bdf
The instruction for medical use of Nolgripp Torgovoye medicine a name Nolgripp Mezhdunarodnoye the unlicensed name Is not present the Dosage form of the Tablet Structure One Tablet contains active agents: paracetamol of 500 mg, Phenylephrinum hydrochloride of 5 mg, caffeine (anhydrous) 30 mg, chlorpheniramine maleate of 2 mg, excipients: corn starch, cellulose microcrystalline, dicalcium phosphate, sodium methylhydroxybenzoate, sodium propilgidroksibenzoat, K-30 povidone, hydroxymethylpropyl cellulose, talc purified of magnesium stearate, silicon dioxide colloidal, sodium glikolit starch, quinolinic yellow (E 104). The description of the Tablet, yellow color of a capsulovidny form with risky on one party. Pharmacotherapeutic group Analgetics-antipyretics. Paracetamol in a combination with other drugs (excepting psikholeptik). The ATX N02BE51 code the Pharmacological Pharmacokinetics Paracetamol properties is characterized by fast and full absorption from a GIT, hypodispersion in fabrics, rather short elimination half-life. Effect of drug begins in 30 min. after oral administration. The maximum concentration in blood comes through 10-60min. also makes near 6mkg/ml, then gradually decreases and in 6 h makes 11-12¼¬ú/ml. Paracetamol is metabolized mainly in a liver by conjugation with a glucuronide, conjugation with sulfate. Elimination half-life makes the 1-3rd. It is removed with urine, mainly in the form of glyukuronidny and sulphatic conjugates. Less than 5% of paracetamol are removed in the form of not changed paracetamol. Phenylephrinum is badly soaked up after intake. Bioavailability - no more than 40%. It is metabolized in intestines enterocytes, after absorption - in a liver. A small part of the accepted dose is removed in not changed view with urine. With breast milk it is removed in the minimum quantities. Caffeine is quickly and completely soaked up from intestines (including from a large intestine). Cmax is reached in 5-90 min. after reception on an empty stomach. It is distributed on bodies and fabrics, including central nervous system, embryonic fabrics and breast milk. Chlorpheniramine the maleate is almost completely soaked up and distributed on fabrics. Cmax is reached in 2-3 h after single dose on an empty stomach. The concomitant use of food considerably reduces bioavailability. The Tablet Nolgripp pharmacodynamics - a combination of four medicinal components for the removal of symptoms of cold, head and muscular pain, fever caused by flu and other upper respiratory tract infections. Paracetamol possesses soothing, febrifugal and weak anti-inflammatory action. The mechanism of action is connected with inhibition of synthesis of prostaglandins, primary influence on the center of thermal control in a hypothalamus. Phenylephrinum hydrochloride alpha adrenomimetik. Has vasoconstrictive effect, reduces puffiness and hyperaemia of mucous membranes of upper airways and adnexal bosoms. Caffeine has moderate promoting effect on central nervous system, reduces feeling of fatigue. Chlorpheniramine a maleate – a blocker anti-histamine H1 - receptors. Causes moderate sedation, has antimuskarinovy activity. Indications - symptomatic therapy of the SARS, flu which are followed by high temperature, fever, head and muscular pain, cold, congestion of a nose the Route of administration and doses the Adult: on 1 tablet 3-4 times daily. The average duration of a course of treatment is 3-5 days. It is not recommended to apply more than 5 days without consultation of the doctor. Not to exceed the specified dose. Side effects Often - drowsiness Seldom - a headache, dizziness - insomnia, alarm, concern, nervousness, hyperexcitability - thrombocytopenia, a leukopenia, an agranulocytosis, a pancytopenia - a cardiopalmus, increase in arterial blood pressure - allergic reactions (skin rash, a small tortoiseshell, a Quincke's disease) - dryness in a mouth - an ischuria - a bronkhoobstruktion Are possible - nausea, vomiting, epigastric pain, diarrhea - a mydriasis, increase in intraocular pressure, accommodation paresis - hepatotoxic and nephrotoxic action, renal colic, a glucosuria, interstitial nephrite, papillary necrosis at long exceeding a dose - hemolytic or aplastic anemia, the Contraindication methemoglobinemia - hypersensitivity to any of drug components - a concomitant use of other drugs containing the substances which are a part of drug - a concomitant use of tricyclic antidepressants, beta blockers - the patients receiving MAO inhibitors including during the period up to 14 days after cancellation - children's and teenage age up to 18 years - pregnancy and a lactation - the profound abnormal liver functions - with care at: deficit glyukozo-6-fosfatdegidrogenazy, diseases of blood, liver and/or renal failure, closed-angle glaucoma, benign hyperplasia of a prostate, Gilbert's syndrome, arterial hypertension, diseases of a thyroid gland, diabetes, bronchial asthma, HOBL, pheochromocytoma. Medicinal interactions Enhances effects of monoamine oxidase inhibitors, sedative drugs, ethanol. Antidepressants, protivoparkinsonichesky means, antipsychotic means, derivatives of a fenotiazin increase risk of development of an ischuria, dryness in a mouth, constipations. Glucocorticosteroids increase risk of developing glaucoma. Paracetamol reduces efficiency of diuretic drugs. Chlorpheniramine along with MAO inhibitors, furasolidone can lead to hypertensive crisis, excitement, a hyper pyrexia. Tricyclic antidepressants strengthen sympathomimetic action, co-administration of a halothane increases risk of developing ventricular arrhythmia. Reduces hypotensive action of a guanetidin who, in turn, enhances alpha adrenostimuliruyushchuyu activity of Phenylephrinum. It is not necessary to appoint with other drugs containing paracetamol and also other non-steroidal anti-inflammatory drugs. Risk of development of hepatotoxic effect increases at simultaneous use of barbiturates, dipheninum, carbamazepine, rifampicin, a zidovudine and other inductors of microsomal enzymes of a liver. Barbiturates reduce febrifugal effect of paracetamol. Against the background of reserpine the increase in arterial blood pressure is possible. Alkaloids of an ergot strengthen an aritmogennost. At a concomitant use of Metoclopramidum, a domperidon or a holestiramin the absorbability of paracetamol decreases. Flukonazol, ketokonazol, meksiletin and terbinafin can moderately increase concentration of caffeine in plasma with possible strengthening of its effect and toxicity. Drug enhances effect of indirect anticoagulants. Patients need to appoint the special instructions Nolgripp with care with a renal failure and a liver and also the patients taking other medicine, possessing hepatotoxic action. It is necessary to avoid intake of alcoholic beverages or use of sedatives (especially barbiturates). Drug can cause excitement of central nervous system. The drug should be taken only in the recommended doses. If symptoms of a disease do not pass within 3-5 days, it is necessary to see a doctor. Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Drug can cause drowsiness therefore during treatment it is necessary to avoid driving of the car and control of other potentially dangerous mechanisms. Overdose Symptoms: pallor of integuments, anorexia, nausea, vomiting, gepatonekroz (the severity of necrosis directly depends on extent of overdose). Toxic effect of drug at adults perhaps after reception over 10-15 g of paracetamol: increase in activity of 'hepatic' transaminases, increase in a prothrombin time (in 12-48 h after reception), the developed clinical picture of damage of a liver is shown in 1-6 days. Seldom the abnormal liver function develops immediately and can be complicated by a renal failure (interstitial nephrite). Treatment: introduction of donators of SH-group and predecessors of synthesis of glutathione - methionine in 8-9 h after overdose and N-Acetylcysteinum - in 12 h. Need for holding additional therapeutic actions (further administration of methionine, in/in administration of N-Acetylcysteinum) is defined depending on concentration of paracetamol in blood and also from time which passed after its reception. The form of release and packing On 4 tablets place in planimetric bezjyacheykovy packings from aluminum foil (strips). On one planimetric packing (strip) is placed in the paper varnished individual packings. On 25 individual packs together with the instruction for use in the state and Russian languages put in a pack from cardboard. Storage conditions Drug should be stored in the dry, protected from light place at a temperature not over 25 about S. Hranit out of children's reach! 4 years not to use a period of storage after expiry date! Prescription status Without prescription "Marion Biotek Pvt. Ltd." Producer B - 49, Sector 67, the Noiade Gautam Budh Nagar (U.P), India the Owner of the registration certificate "Marion Biotek Pvt. Ltd.", India the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) of Spectramax LLP, Republic of Kazakhstan, Almaty, Seyfullin Ave. 458-460/95, office 312 Number of phone/fax +7 (727) 344-94-37 (8)
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