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Metromikon neo 14s vaginal suppositories

  • $20.90
Sku: 6fa012751d63
The instruction for use
of medicine for experts

of METROMIKON - The NEO

Trade name
of Metromikon-Neo

the International unlicensed name
Is not present

the Dosage form
Suppositories vaginal

Structure
One suppository contains
active agents - Miconazolum nitrate of-100 mg, metronidazole – 500 mg,
excipient - semi-synthetic gltserida


the Description
Suppositories of a cylindrical form, white color from a zheltovata a shade. On longitudinal section – homogeneous mass, without impregnations. On a cut the existence of an air porous core and funneled deepening is allowed.

The pharmacotherapeutic group
Antiprotozoan, antibacterial agent
the Code of automatic telephone exchange G01AF20

the Pharmacological

Pharmacokinetics Metronidazole properties at intravaginalny use in the form of suppositories is soaked up in insignificant degree through mucous membranes and has practically no systemic action. Miconazolum is soaked up in insignificant quantity through mucous membranes. Drug is metabolized in a liver with formation not of active metabolites which are removed with urine. In an invariable look it is removed with a stake.
The pharmacodynamics
Nitro group of a molecule of the metrondazol which is an acceptor of electrons is built in a respiratory chain of protozoa and anaerobe bacterias (competes about an electron the competing proteins – flavoproteins, etc.) that breaks respiratory processes and causes death of cells. Besides, at some anaerobe bacterias has ability to suppress synthesis of DNA and to cause its degradation.
The fungicide and fungistatic effect of Miconazolum is caused by inhibition biosynthesis of ergosterol of a cover and plasma membranes of mushrooms, and the same change of lipidic structure and permeability of a cell wall of mushrooms. Metronidazole is active concerning protozoa: Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba hisolytica, and also anaerobic gram-negative microorganisms: bacteroids, including
the Bacteriodes fragilis group (B. Caccae, B. unifomis, B. distasinis, B. ovatus, B.theraiotaomicron, B. vulgatus), Fusobacterium, Prevotella (P. buccae, P. disiens), anaerobic grams of positive bacteria of Clostridium, Eubacterium, peptococcus, Peptostreptococcus.
Also yeast are most sensitive to Miconazolum of a dermatomitseta. Also Miconazolum is effective concerning some gram-positive microorganisms, including staphylococcus and streptococci.

Indications
- a mecotic vaginitis and an urethritis
- the mephitic gangrenes caused by microorganisms, sensitive to metronidazole,
- vaginal and vulvovaginal candidiases
- the superinfection caused by gram-positive microorganisms

the Route of administration and
Intravaginalno's doses. On 1 suppository once a day, just before a dream, within 10 days in a row. Treatment is continued within several days after disappearance of all symptoms of a disease.

Side effects
- an itching, burning sensation
- irritation of a mucous membrane of a vagina, especially in

the Contraindication initiation of treatment
- hypersensitivity to metronidazole and Miconazolum (including to other derivatives of a nitromidazol)
- abnormal liver functions
- pregnancy

Medicinal interactions
are noted

the Special
instructions Use of Suppositories with metronidazole and Miconazolum reduces reliability of mechanical contraception (latex the containing means: condoms, vaginal diaphragms) the possibility of pregnancy or infection with diseases, sexually transmitted therefore during treatment it is recommended to refrain from sex life is also not excluded. In case of infection of the sexual partner and for an opportunity exception re simultaneous treatment of both partners is obligatory for an infection.
Pregnancy and a lactation
the Issue of a possibility of use in the period of a lactation is resolved individually. At pregnancy the drug use is contraindicated.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
are not established.

Overdose
Due to the low adsorption of drug the overdose cases at observance of the recommended doses on are revealed.

Form of release and packing
Suppositories vaginal. Each individual packing contains 14 suppositories and

Storage conditions
to Store the instruction for use in the dry, protected from light place at a temperature of 15-250C
to Store out of children's reach!


3 years
not to apply an expiration date after the expiration date specified on packing.

Prescription status
According to the prescription

the Producer
the Pharmaceutical
enterprise FARMAPIM SRL Republic of Moldova, MD-
of 2028 Chisinau, G. Tudor St., 3
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