MACMIROR® (Nifuratel) and MACMIROR® Complex (Nifuratel, Nystatin)
- $55.00
What is Macmiror?
Macmiror is an antimicrobial medication with the active ingredient Nifuratel, specifically designed to treat various infections, particularly in the urinary and genital tracts.
It is available as coated tablets (200 mg each) and effectively combats a wide range of pathogens, including bacteria, fungi, and parasites.
The Macmiror Complex, a combination of Nifuratel and Nystatin, is formulated as vaginal capsules to provide targeted treatment for gynecological infections, offering both antifungal and antibacterial properties.
What is the Composition of Macmiror and Macmiror Complex?
Understanding the composition of Macmiror and Macmiror Complex can help in identifying any potential allergens or sensitivities before starting treatment.
Macmiror Tablets:
- Active Ingredient: Each tablet contains 200 mg of Nifuratel, an antimicrobial agent that works against bacteria, fungi, and protozoa.
- Inactive Ingredients: Corn starch, rice starch, polyethylene glycol 6000, talc, magnesium stearate, gelatin, gum arabic, sucrose, magnesium carbonate, titanium dioxide (E171), and E-wax. These additives are used to form the tablet’s coating, enhance stability, and improve absorption.
Macmiror Complex Vaginal Capsules:
- Active Ingredients: Each capsule contains 500 mg of Nifuratel and 200,000 IU of Nystatin. Nifuratel provides a broad antimicrobial effect, while Nystatin is specifically antifungal, targeting Candida and other yeast infections.
- Inactive Ingredients: Dimethicone as well as a capsule shell made of gelatin, glycerin, sodium ethylparaben, sodium propylparaben, titanium dioxide (E171), and yellow iron oxide (E172). These substances help maintain capsule form, improve insertion, and provide color.
What Conditions Does Macmiror Treat?
Macmiror and Macmiror Complex are prescribed to treat several infections due to their wide-ranging antimicrobial effects:
Vulvovaginal infections: This includes infections caused by bacteria, fungi like Candida, Trichomonas, and Chlamydia. Macmiror Complex is particularly beneficial here, as it treats both fungal and bacterial components of mixed infections.
Urinary Tract Infections (UTIs): It’s effective for infections such as pyelonephritis (kidney infections), urethritis (inflammation of the urethra), cystitis (bladder infection), and pyelitis, addressing a range of bacteria that cause these conditions.
Intestinal Infections: Macmiror treats protozoal infections like amebiasis and giardiasis, which are common in the intestines and often cause digestive symptoms.
Upper Gastrointestinal Infections Associated with Helicobacter pylori: Macmiror can be used in combination therapy for chronic inflammation of the digestive tract caused by the H. pylori bacteria, often linked with gastritis and stomach ulcers.
How Should You Take Macmiror?
The dosage and method for taking Macmiror vary depending on the condition being treated:
For Vulvovaginal Infections: Adults typically take one 200 mg tablet three times daily after meals for a 7-day course. Both partners should undergo treatment to prevent reinfection.
For Urinary Tract Infections (UTIs): Adults may need 3-6 tablets daily, depending on the infection severity, for 7-14 days. In some cases, the treatment may be extended or repeated as per a doctor's advice.
For Amebiasis: The standard adult dose is 2 tablets, taken 2-3 times daily, for 10 days to fully eliminate the infection.
For Giardiasis: Adults generally take 2 tablets, 2-3 times per day, for 7 days.
For H. pylori Infections: The typical dose is 2 tablets, 2-3 times per day, for 7 days as part of a combination therapy.
For Macmiror Complex (vaginal capsules), the recommended dosage is one capsule inserted vaginally once daily at bedtime, for 8 days or as instructed by a doctor. Capsules should be inserted as deeply as possible for optimal effect.
How Effective Is Nifuratel in Treating Gynecological and Urinary Tract Infections?
Research into Nifuratel demonstrates its significant effectiveness in treating gynecological and urinary tract infections due to its broad-spectrum activity.
Studies such as those published in the Journal of Chemotherapy and European Journal of Clinical Microbiology & Infectious Diseases highlight that Nifuratel has potent activity against pathogens like Candida species, Trichomonas vaginalis, and Escherichia coli, which are common causes of vulvovaginal infections and UTIs.
For instance, a study analyzing Nifuratel’s action against mixed infections found it particularly effective for complex infections involving both bacteria and fungi, making it suitable for patients with recurring or persistent infections.
Furthermore, research has shown that Nifuratel, combined with Nystatin in the Macmiror Complex, improves antifungal outcomes, especially for infections caused by Candida, as documented in clinical trials.
These studies underscore Nifuratel’s high tolerability, low resistance rates, and efficacy in complex infection management, supporting its use in treating a wide range of gynecological and urinary tract conditions.
What Precautions Should Be Taken When Using Macmiror?
Before beginning treatment with Macmiror, keep these points in mind:
Avoid Alcohol: Alcohol consumption while on Macmiror may result in dizziness and nausea, as alcohol can interfere with how the medication is metabolized.
Refrain from Sexual Activity: During treatment for vaginal infections, avoid sexual intercourse to prevent reinfection. A healthcare provider may also recommend treatment for your partner.
Pregnancy and Breastfeeding: Consult a healthcare provider if you are pregnant, breastfeeding, or planning a pregnancy. Macmiror is only used during pregnancy if absolutely necessary and under strict medical supervision.
Age Restrictions: Macmiror tablets are generally not recommended for children under 6 years, and Macmiror Complex is not advised for use in young girls who haven’t reached puberty or in virgins.
Who Should Avoid Using Macmiror?
Macmiror is generally safe but is not suitable for everyone. Avoid Macmiror if you:
- Have hypersensitivity to nifuratel, nystatin, or any of the tablet or capsule ingredients.
- Have certain sugar intolerances, as Macmiror tablets contain sucrose; consult your doctor if this applies to you.
What Are the Possible Side Effects of Macmiror?
Like all medications, Macmiror may cause side effects in some people, though these are generally rare:
Gastrointestinal Issues: Some people may experience nausea, vomiting, a bitter taste in the mouth, heartburn, or abdominal discomfort.
Skin Reactions: Rarely, users may have allergic reactions like rashes, itching, or localized swelling. If these occur, stop treatment and consult a doctor.
If you experience any side effects or have concerns about how the medication is affecting you, seek guidance from a healthcare professional.
How Should Macmiror Be Stored?
Store both Macmiror and Macmiror Complex capsules in a cool, dry place at a temperature not exceeding 25°C (77°F) and away from direct light.
Keep all medications in a location inaccessible to children to ensure safety.
