Longidaza® 3000 IU 5's lyophilisates for solution for injection

What is Longidaza®?

Longidaza® is a medication designed for the treatment and prevention of conditions associated with the excessive growth of connective tissue. It contains the active ingredient bovhyaluronidase azoximer and comes in the form of a lyophilized powder for injection preparation. The medication is primarily used in combination therapy to address issues in various medical fields including gynecology, urology, surgery, dermatology, cosmetology, pulmonology, and rheumatology.

How Does Longidaza® Work?

Longidaza® helps to break down hyaluronic acid, a key component in connective tissue. By reducing the viscosity of this acid, Longidaza® facilitates the better absorption and dispersion of other medications and improves tissue permeability. This makes it effective in reducing fibrosis, adhesions, and scars.

What Conditions Can Longidaza® Treat?

Gynecological Conditions

Longidaza® is used to treat and prevent pelvic adhesions due to inflammatory diseases, tubal-peritoneal infertility, intrauterine synechiae, and chronic endometritis.

Urological Conditions

It is effective in treating chronic prostatitis and interstitial cystitis.

Surgical Applications

Longidaza® aids in the prevention and treatment of postoperative adhesions and promotes healing in long-lasting wounds.

Dermatological and Cosmetological Uses

This medication is used for the treatment of limited scleroderma, non-infectious onychodystrophy, keloid and hypertrophic scars, and severe acne scars (post-acne).

Pulmonology and Phthisiology

Longidaza® treats pulmonary fibrosis, fibrosing alveolitis, and various forms of tuberculosis.

Rheumatological Uses

It helps in managing joint contractures, including Dupuytren's contracture, tendonogenic contractures, arthrosis, ankylosing spondylitis, and hematomas.

What Should You Know Before Using Longidaza®?

Contraindications

Do not use Longidaza® if you have:

• Hypersensitivity to the active substance or any excipients.
• Acute infectious diseases.
• Pulmonary bleeding or hemoptysis.
• Recent vitreous hemorrhage.
• Acute renal failure.
• Are under 18 years of age.
• Are pregnant.

Special Warnings

Consult your doctor before starting treatment, and inform them of any other medications you are taking. Follow the prescribed instructions strictly. If you miss a dose, continue with the regular schedule without doubling the next dose.

Possible Interactions

Longidaza® can be combined with antibiotics, antivirals, antifungals, and bronchodilators. However, its enzymatic activity may be reduced when used with heparin, high doses of NSAIDs, corticosteroids, ACTH, estrogens, or antihistamines. Avoid concurrent use with furosemide, benzodiazepines, phenytoin, and adrenaline.

How to Use Longidaza®?

Dosage and Administration

For injection, dissolve the lyophilized powder in 1.0-2.0 ml of 0.5% procaine solution, or in 0.9% sodium chloride solution if procaine is not tolerated. Inject the solution as prescribed by your doctor.

Storage Instructions

Store Longidaza® at temperatures between 2°C and 8°C (35.6°F and 46.4°F). Do not freeze. Keep out of reach of children.

Shelf Life

Longidaza® has a shelf life of 2 years. Do not use it beyond the expiration date indicated on the packaging.

What Are the Side Effects of Longidaza®?

Common side effects include pain at the injection site. Occasionally, redness, itching, and swelling may occur but typically resolve within 48-72 hours. Rarely, allergic reactions may occur. If you experience any adverse effects, contact your healthcare provider immediately.