Lincomycin hydrochloride 30% / 1 ml 10s solution for injection in ampoules

The instruction for use
of medicine for experts

of Lincomycin a hydrochloride

the Trade name
of Lincomycin a hydrochloride

the International unlicensed



name Lincomycin Dosage Form Solution for injections of 30%, 1 ml, 2 ml

Structure
of 1 ml of solution contains
active agent – hydrochloride lincomycin (in terms of
lincomycin the basis) 300.0 mg
excipients: disodium salt etilendiamintetrauksus-
tetraacetic acid (EDTA), sodium hydroxide of 0.1 M solution, water for injections.

The description
Transparent, colourless or slightly yellowish liquid with a specific smell.

Pharmacotherapeutic group
Antimicrobial drugs for system use. Linkozamida
Kod the automatic telephone exchange of J01FF02

the Pharmacological

Pharmacokinetics At properties parenteral administration is quickly soaked up in blood, well gets into tissues of lungs, a liver, kidneys, through a placental barrier, into mother's milk, in high concentrations it is found in a bone tissue. Through a blood-brain barrier lincomycin gets slightly, in meningitis the permeability of a blood-brain barrier increases. The maximum concentration of drug in 2-3 h.
Elimination half-life about 5 hours. Out of an organism it is brought with bile, partially with urine.
Pharmacodynamics
Antibacterial agent. Suppresses protein synthesis of bacteria owing to reversible linking with a subunit of ribosomes, breaks formation of peptide bonds. It is effective concerning gram-positive microorganisms (stafilokokk, pneumococci, a diphtheria stick), some anaerobic spore-forming bacteria (clostridiums), gram-negative anaerobe bacterias (bacteroids) and mycoplasmas. Affects microorganisms (especially staphylococcus), resistant to other antibiotics. The resistance develops slowly. In therapeutic doses has bacteriostatic action, in higher – bactericidal.

Indications
Apply at infectious - inflammatory diseases of a heavy course
- sepsis
- osteomyelitis
- a septic endocarditis
- pneumonia
- lung abscess
- a pleura empyema
- purulent infections of skin and soft tissues, erysipelatous inflammation
- otitis
- other infections caused by the strains of staphylococcus and other
gram-positive microorganisms resistant to penicillin
and other antibiotics

the Route of administration and doses
Intramusculary, intravenously.
The dose for adults at parenteral administration makes 2 ml (600 mg) 1-2 times a day. At a heavy course of an infection it is possible to increase a daily dose to 2.4 g. To children appoint in a daily dose 10-20 mg/kg irrespective of age. Intravenously the drug is administered only by drop infusion with a speed of 60-80 thaws a minute. Before introduction of 2 ml of 30% of solution of drug (600 mg) dilute 250 ml of isotonic solution of sodium chloride.
Duration of treatment is 7-10 days, in osteomyelitis a course of treatment up to 3 weeks and more. In order to avoid development of thrombophlebitis and aseptic abscess it is deeply better to enter intramusculary. Intravenously it is impossible to enter without preliminary cultivation.


Side effects
- urticaria, a Quincke's edema, an acute anaphylaxis
- a leukopenia, a neutropenia, thrombocytopenia, tranzitorny increase
in content of bilirubin and hepatic transaminases in blood plasma
- an abnormal liver function, jaundice
– phlebitis (at intravenous administration)
At fast intravenous administration
– a lowering of arterial pressure, relaxation of skeletal
muscles, dizziness, the general weakness
At prolonged use
– candidiasis, pseudomembranous colitis

of the Contraindication
- hypersensitivity to lincomycin and clindamycin
- the profound abnormal liver functions and/or kidneys
- diarrhea
- myasthenias
- pregnancy, the lactation period
- the neonatality period (up to 1 month).

Medicinal interactions
Strengthens the muscle relaxation caused by kurarepodobny means. Anti-diarrheal drugs, chloramphenicol, erythromycin weaken effect. Pharmaceutical it is incompatible (in one syringe) with Kanamycinum and novobiocin.

Special instructions
In an abnormal liver function and/or kidneys it is necessary to reduce a single dose of lincomycin by 1/3 – 1/2 and to increase an interval between introductions. At prolonged use the systematic control of functions of kidneys and a liver is necessary.
In case of development of pseudomembranous colitis lincomycin it is necessary to cancel and appoint Vancomycinum or bacitracin.
The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
Should be careful at control of motor transport or potentially dangerous mechanisms

Overdose
Symptoms: a diarrhea, a leukocytosis, fever, abdominal pains, discharge with stool of blood and slime.
Treatment - drug withdrawal and prescribing of ion-exchange resins (Colestyraminum, kolestipol), in hard cases is shown compensation of loss of liquid, electrolytes and protein, Vancomycinum in a daily dose of 0.5-2 g (on 3-4 receptions) for 10 days or bacitracin.

A form of release and packing
of 30% solution for injections in ampoules on 1 ml and 2 ml in a cardboard pack on 10 pieces, in blister strip packaging on 5 or 10 pieces.


To Store storage conditions in the dry, protected from light place, at a temperature from + 2 wasps to + 30 wasps.
To store out of children's reach!

An expiration date
3 years
After an expiration date not to use drug.

Prescription status
According to the prescription


JSC Khimpharm Producer,
Shymkent, REPUBLIC OF KAZAKHSTAN, Rashidov St.,/N, ph.: 560882