The instruction for medical use of Kanefron® medicine H the Trade name of Kanefron® of N the International unlicensed name Is not present the Dosage form of the Drop for intake of 100 ml Structure of 100 g of drug contain active agents: 29 g of aqueous-alcoholic extract from medicinal vegetable raw materials: Centaury of a grass of 0.6 g of Lyubistok medicinal roots of 0.6 g of Rosemary of leaves of 0.6 g excipients: Ethanol, water the Transparent or slightly rather turbid liquid purified the Description, yellowish-brown color, with a root Lyubistoka smell. At storage the loss of a deposit is possible. Pharmacotherapeutic group Urinogenital system and sex hormones. Urological drugs. Other drugs for treatment of urological diseases. The ATX G04BX code the Pharmacological Pharmacokinetics Measurement properties of three markers in plasma of animals in preclinical trials was shown by dozo-proportional influence after oral administration of high doses of Kanefron® of N in toxicity researches at repeated introduction. Besides, at repeated introductions of accumulation it was not observed. A pharmacodynamics In various clinical trials the use of Kanefron® of N led to fast decrease in number of the complaints connected with inflammatory diseases of urinary tract. The results received during these clinical trials demonstrate anti-inflammatory, spasmolytic, anti-nociceptive and antibacterial effects of Kanefron® of N. of Kanefron® of N showed antioxidant and also anti-inflammatory activity, lowered physiologically relevant concentration of reactive forms of oxygen and nitrogen, interfered with release of E2 prostaglandin and cytokines and also interfered with products of leukotrienes. Канефрон® the N reduced adhesion of uropatogenny bacteria to epithelial cells of a bladder. Individual Kanefron® components H have antibacterial activity and have diuretic effect which maintains antibacterial activity as bacteria are washed away from uric ways. Researches of toxicity Kanefron® of N of drops, except mutagenicity researches, it was not conducted. However the toxicity of tablets and active agent, i.e. mix of medicinal vegetable raw materials 1:1:1, is studied widely. Data on the cancerogenic potential of Kanefron® of N are absent. Indications - acute and chronic cystitis - as an additional tool of treatment in specific therapy of pyelonephritis, glomerulonephritis, interstitial nephrite - prevention of formation of urinary stones - after operational removal of urinary stones the Route of administration and doses the Adult: on 50 drops 3 times a day. After easing of sharpness of a disease it is necessary to continue treatment within 2 – 4 weeks. Accept a single dose in the morning, during the lunchtime and in the evening. If necessary, to soften bitter taste, Kanefron® of N can be accepted together with other liquids. Duration of treatment is defined by the attending physician. Because of good tolerance drug is shown for prolonged use. At use of drug the plentiful consumption of liquid is recommended. When using you keep a bottle in vertical position. Side effects classify Undesirable reactions depending on frequency. At assessment of frequency of emergence of undesirable reactions for a basis the following categories were put: very often: 1/10chasto: ≥1/100, but & lt, 1/10 infrequently: ≥1/1000, but & lt, 1/100 is rare: ≥1/10000, but & lt, 1/1000 is very rare: & lt, 1/10000chastota is unknown: it cannot be estimated on the basis of the available data often: - gastrointestinal disorders (for example nausea, vomiting, diarrhea) are possible: - allergic reactions to drug components (for example rash, an itching) At the first signs of allergic reaction it is necessary to stop administration of drug. Contraindications - the increased individual sensitivity to any components of drug, to other plants of family of umbrella (Umbelliferae) (for example, an anise, fennel) or to p-propenyl anisole (component of essential oils) - ulcer of stomach and duodenum during an acute period - children's age till 18th year - hypostases owing to dysfunction of heart or kidneys and/or if limited consumption of liquid was recommended the doctor. Medicinal interactions Are unknown. The combination with antibacterial medicines is possible. Special instructions At long high temperature, spasms, presence of blood in urine, disturbances of urination and a sharp ischuria it is necessary to consult immediately with the doctor. This drug contains 19% of alcohol on volume. Drops should not be applied to intake the patient having alcoholism and also after successful antialcoholic treatment. With caution patients should take with diseases of a liver or epilepsy. In storage time the easy turbidity or loss of a deposit is allowed. It does not affect efficiency of drug. Before the use to shake up! Pregnancy and a lactation of Kanefron® of N it is necessary to accept during pregnancy only on doctor's orders, after assessment by the doctor of a ratio of advantage risk of its use and strictly following instructions on its use. Medicine should not be accepted to women during breastfeeding. Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Drug does not affect ability to run transport and to perform work with potentially dangerous mechanisms Overdose was not reported About cases of overdose. Symptomatic treatment. A form of release and packing of 100 ml of drug in a bottle from dark glass with the dosing drop device from above, with the screw-on cover and control of the first opening. On 1 bottle together with the instruction for medical use in the state and Russian languages put Storage conditions in a folding cardboard pack to Store in original packing, at a temperature not over 25 ºС. To store out of children's reach! Period of storage 2 years. The use period after opening of a bottle of 6 months. Not to apply after an expiration date. Prescription status Without prescription the Producer Bionorika XIE, D-92308 of Noymarkt / Germany the Holder of the registration certificate Bionorika XIE, D-92308 of Noymarkt / Germany the Name, the address and a contact information (phone, the fax, e-mail) of the organization in the territory of the Republic of Kazakhstan, the accepting claim (offer) on quality of medicines from consumers and responsible for post-registration observation of safety of medicine of Bionorika KAZ LLP 050060 Almaty, Zharokov St. 331, ph. 250-93-99
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