Kandibene 30g 1% cream in the tube

  • $7.10
Sku: 9a9bd51b876a
Ingredient: Clotrimazole
The instruction
for medical use


of Kandibene® medicine

the Trade name
of Kandibene®

the International unlicensed






name Clotrimazolum Dosage Form Cream of 1% 30 G Structure of 100 G of Cream soderzhataktivny substance - Clotrimazolum of 1 g,
excipients: benzyl alcohol, sorbitan stearate, polysorbate 60 (Thwin 60), tsetit palmitate, alcohol cetyl stearyl, 2 octyllauryl alcohol
(eutanol G), water




the Pharmacotherapeutic group cleaned the Description White homogeneous cream
Antifungal drugs for treatment of a disease of skin.
Imidazole derivatives.
The code of automatic telephone exchange D01AC01

the Pharmacological

Pharmacokinetics Pharmacokinetic Researches properties after vaginal use showed that only the minimum quantities of Clotrimazolum (less than 3-10% of a dose) are absorbed.
Concentration in blood plasma make less than 10 ng/ml, and do not cause the system effects or adverse effects which are subject to quantitative definition. Clotrimazolum is acquired in a liver in inactive hydroxyl derivatives, by means of oxidation and splitting
of an imidazolny ring (deaminirovaniye, O-dealkylation), and removed, mainly, with bile.
The pharmacodynamics
of Kandibene® possesses fungistasis. Due to suppression of biosynthesis of the ergosterol which is a component of a cellular membrane of mushrooms the permeability of a membrane is broken. Besides, in fungistatic concentration of Kandibene® leads to toxic increase in concentration of peroxide of hydrogen that, promotes cellular death of mushrooms. Кандибене® possesses a broad spectrum of activity. It is active concerning dermatophytes, mold mushrooms, mushrooms of the sort Candida, dimorphous fungi. MIK for these types of fungi make less than 0.062 - 4 (-8) mkg/ml of substrate.
Кандибене® suppresses reproduction of Corynebacteria and gram-positive cocci, except enterococci, in concentration of 0.5 - 10 mkg/ml of substrate, and substance is trikhomonadotsidny at 100 mkg/ml.

Indications
- fungus diseases of skin, mycoses of skin folds, feet, an onychomycosis
- the chromophytosis, an erythrasma, superficial candidiases caused
by dermatophytes, barmy (including the sort Candida), the mold and other mushrooms and activators sensitive to Clotrimazolum
- the mycoses complicated by a secondary pyoderma

the Route of administration and doses
of Kandibene® apply cream with a thin layer on previously cleaned (with the use of soap with neutral value rn) and dry affected areas
of skin. Cream is applied by 2-3 times a day.
Treatment duration - is individual and depends on weight of a course of the disease, localization of pathological changes and efficiency of therapy.
For ensuring successful treatment the use of Kandibene® cream is not stopped right after stopping of acute symptoms of a disease.
Usually treatment of dermatomycoses is carried out not less than within 4 weeks, multi-colored depriving - 1-3 weeks.
In fungus diseases of skin of legs it is recommended to continue therapy not less than within 2 weeks after stopping of symptoms of a disease.

Side effects
Sometimes
- passing reddening, feeling of pricking and burning.

Contraindications
- the hypersensitivity to Clotrimazolum or other components, including to cetostearyl alcohol

Medicinal interactions
Clotrimazolum can reduce action of other local antifungal means, especially half-yen antibiotics (nystatin, natamitsin, Amphotericinum B). In high concentrations dexamethasone reduces antifungal effect of Clotrimazolum. Propyl ether of p-hydroxybenzoic acid in high concentrations strengthens antifungal effect of Clotrimazolum.

The special
instructions Drug it is not intended for use in ophthalmologic practice.
At treatment of onychomycoses it is necessary to watch that the processed nail plates were shortly cut and had a rough surface for the best penetration of active agent of drug.
Pregnancy and the period of a lactation
the Issue of expediency of prescribing of drug at pregnancy has to be resolved individually after consultation of the doctor.
Because of the minimum absorption of Kandibene® at external use, there is no risk when feeding by a breast. Putting Clotrimazolum directly on the lactating chest gland is contraindicated.
Features of influence of medicine on ability to run the vehicle and potentially dangerous mechanisms
Are unknown.

The overdose
Use of Kandibene® in the raised doses does not cause any certain reactions and states, life-threatening.

The form of release and packing
On 30 g of cream place in aluminum tubas with the polyethylene screw-on cover.
On 1 tuba together with the instruction for medical use in the state and Russian languages put in a box of cardboard.


To Store storage conditions at a temperature not above 25 °C.
To store out of children's reach!


2 years
not to apply a period of storage after an expiration date!

Prescription status
Without prescription


Merkle GmbH Producer, Germany

the Owner of the registration certificate
ratiopharm GmbH, Germany
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) of ratiopharm Kazakhstan LLP, 050023, Almaty, mdt Baganashyl, Syrgabekov St. 17, phone number: +7 (727) 269 69 92, 321 02 72, 321 02 73, Fax: +7 (727) 321 02 74, the e-mail address: info@ratiopharm.kz
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