Dolobene Gel (Heparin, Dimethyl Sulfoxide, Dexpanthenol)

What is Dolobene Gel?

Dolobene Gel is a topical treatment designed to relieve pain, reduce inflammation, and support tissue repair in muscles, joints, and soft tissues.

This gel combines three active ingredients, each with unique properties that make Dolobene effective in treating a wide range of musculoskeletal and vascular conditions:

1. Heparin is a natural anticoagulant that helps improve blood circulation at the application site, reducing blood clot formation. It also aids in resolving bruises and swelling, promoting faster recovery of damaged tissues.

2. Dimethyl Sulfoxide (DMSO) is an anti-inflammatory and analgesic agent. It penetrates the skin quickly, providing pain relief and reducing inflammation directly at the site of injury. Additionally, DMSO enhances the penetration of the gel’s other ingredients, making the treatment more effective.

3. Dexpanthenol supports skin health by promoting cell regeneration and providing hydration. It aids in soothing irritated skin and assists in the repair of damaged tissues, which is particularly beneficial in treating injuries that cause swelling or bruising.

Together, these components work to alleviate discomfort, reduce swelling, and improve healing in cases of bruises, sprains, joint injuries, and conditions involving muscle or tendon inflammation. Suitable for a variety of injuries, Dolobene Gel offers both pain relief and restorative support in a single application.

What Conditions Can Dolobene Gel Treat?

Dolobene Gel is beneficial for treating a range of musculoskeletal issues and injuries, including:

• Bruises, muscle and soft tissue inflammation, and injuries from strains or trauma
• Joint injuries with ligament sprains or tears
• Neuralgia (nerve pain)
• Conditions like shoulder periarthritis, tennis elbow, tendonitis, and bursitis
• Various forms of arthritis, including osteoarthritis with affected surrounding tissues
• Surface thrombophlebitis and venous ulcers related to chronic venous insufficiency

Who Should Avoid Using Dolobene Gel?

Certain conditions make Dolobene Gel unsuitable for use. Avoid using this gel if you have:

• Known sensitivity to any ingredient in the formula
• Severe liver or kidney dysfunction
• Cardiovascular conditions like severe angina, recent heart attack, or stroke
• Bronchial asthma
• Are pregnant, breastfeeding, or children under the age of 5

Also, Dolobene Gel should not be applied to mucous membranes (eyes, nose, mouth), open wounds, or damaged skin.

Are There Any Possible Interactions with Other Medications?

Dolobene Gel may interact with other medications, especially if applied simultaneously on the skin. Notably:

• It can increase the skin's absorption of other topical medicines.
• It may cause severe toxic reactions when combined with anti-inflammatory medications containing sulindac.
• When used with blood-thinning medications like anticoagulants and aspirin, there may be an increased risk of bleeding.

Are There Any Special Warnings While Using Dolobene Gel?

Using Dolobene Gel can cause increased sensitivity to sunlight.

During treatment, it is best to avoid direct sun exposure or tanning beds. If any hypersensitivity reactions occur, discontinue use immediately.

How to Apply Dolobene Gel?

To use Dolobene Gel effectively:

1. Apply a thin layer on the affected area.
2. Squeeze 3–4 cm of gel from the tube, enough to cover an area like the knee.
3. Massage gently into the skin, avoiding direct application on wounds.
4. Clean the area beforehand to remove dirt, cosmetics, or other substances.
5. Repeat this 2–4 times daily for 7–10 days or until symptoms improve.

If you notice no significant improvement within 10 days, consult a healthcare provider.

Can Dolobene Gel Be Used with Physical Therapy Techniques?

Yes, Dolobene Gel can enhance certain physical therapy techniques, including:

• Iontophoresis: Using a mild electrical current, this gel can improve heparin absorption and alleviate pain and swelling.
• Ultrasound Therapy (Phonophoresis): The gel serves as a good contact medium, amplifying the therapeutic effects of ultrasound.

Are There Any Side Effects of Dolobene Gel?

While generally well-tolerated, possible side effects include:

• Common: Redness, itching, and a slight burning sensation, which usually subside with continued use.
• Uncommon: Allergic skin reactions, taste changes, and a temporary garlic-like breath odor.
• Rare: Immediate allergic reactions, mild cardiovascular complaints, or gastrointestinal issues when applied over large skin areas.

What Should I Do in Case of Overuse or Unusual Reactions?

Due to low systemic absorption, overdose is unlikely.

However, if side effects persist or are bothersome, stop use and consult a healthcare professional.

How Should I Store Dolobene Gel?

Store Dolobene Gel at a temperature not exceeding 25°C (77°F) and keep it out of children’s reach.

After opening, the product remains usable for up to one year, but do not use it past its expiration date.