Dolobene 20g gel tube

  • $14.50
Sku: 9f1ba7c1751f
Ingredient: Dimethyl Sulfoxide
The instruction for medical use

of Dolobene medicine gel

the Trade name
of Dolobene gel

the International unlicensed name
Is not present

the Dosage form

100 g of gel contain
active agents: heparin sodium 50.000 ME (0.227 - 0.417 g),
dekspantenol 2.500 g,
dimethyl sulfoxide of 10% of water of 16.660 g,
excipients: carbomers (karbopol 98 NF), trometamol, makrogol glitserol hydroxystearate, isopropyl alcohol, oil rosemary, oil of a mountain pine, oil tsitronellevy, the water purified.

Transparent, slightly muddy colourless or yellowish gel.

The pharmacotherapeutic
Heparin group - the containing drugs for topical administration. Heparin in a combination with other drugs.
The ATX C05BA53 code

the Pharmacological

Pharmacokinetics Later properties of drawing on skin a dimethyl sulfoxide (DMSO) quickly gets through all biological membranes, including through skin. Elimination half-life 3-4 hours. Concentration of DMSO in fabrics (skin, muscles, a synovial membrane) are 100-10 times higher, than in blood plasma. More than 90% of DMSO are allocated through kidneys, about 6% exhaust through lungs.
Heparin quickly gets into skin: within the first hour after putting gel the concentration in the subject fabrics corresponds to concentration which are reached later in/in introductions 5000 ME heparins.
Dekspantenol (alcohol of pantothenic acid – group B vitamin) after a skin resorption quickly is oxidized in pantothenic acid. There is practically no system resorption.
A pharmacodynamics
Effect of drug is caused by the active agents which are its part: dimethyl sulfoxide, heparin sodium and dekspantenol.
The dimethyl sulfoxide possesses the anti-inflammatory, anti-exudative and local anesthetizing action. Gets through biological membranes, including, through skin, promoting the best and deep penetration into fabrics of other medicinal substances applied along with it.
Heparin, thanks to an inactivation of biogenous amines in fabric, shows anti-inflammatory action, improves local blood circulation. Heparin slows down effect of hyaluronidase and promotes regeneration of connective tissue.
Dekspantenol shows anti-inflammatory and dermatoprotektivny action, stimulates regeneration processes. After absorption turns into pantothenic acid which participates in numerous processes of a metabolism, being coenzyme A component, due to improvement of processes of epithelization and granulation promotes regeneration of the damaged sites of skin and improves Dolobene's shipping of gel.

- hematomas and inflammations of soft tissues, muscles, sinews, tendinous vaginas, ligaments after bruises, squeezings, injuries
- neuralgia
- injuries of joints with stretching or a rupture of sheaves
- a humeroscapular periarthritis, a shoulder epicondylitis ('the tennis player's elbow'), tendinites (inflammations of sinews), a tendovaginitis (inflammations of tendinous vaginas), a bursitis (inflammations of a mucous bag of joints)
- arthritises, the deforming osteoarthritis (in the presence of defeat of periartikulyarny fabrics)
- superficial thrombophlebitises, trophic ulcers against the background of chronic venous insufficiency.

The route of administration and doses
apply the Drug Dolobene thin, a blanket on affected areas of skin or on skin over painful area (swelling, puffiness,
inflammation), trying to avoid putting gel directly on wounds and grazes. The site of skin to which the drug Dolobene is applied has to be cleaned from dirt, cosmetics, other medicines and chemicals. When using bandages it is necessary to wait after putting gel several minutes that the bulk of gel was soaked up and alcohol (isopropanol) evaporated. Especially important it when the bandage badly permeable is applied to air. It is necessary to remember that hit of drug on open wounds causes pain reaction since gel contains alcohol (isopropanol).
To cover all surface of the hurt knee, it is usually enough to squeeze out 3-4 cm of gel from a tuba. The procedure is repeated by 2-4 times a day within 7-10 days or before disappearance of such symptoms of a disease as pain, a swelling, hypostasis, inflammation.
In case within 10 days of treatment there does not occur distinct improvement, it is necessary to see a doctor.
Dolobene and an ionophoresis
This drug can be used at an ionophoresis. The heparin which is contained in the drug Dolobene in relation to pH of skin acts as anion. Putting drug under the cathode promotes the increased penetration of heparin into the struck area, and a dimethyl sulfoxide shows synergy action with effect of electric current (anesthesia, reduction of local hypostasis).
Precautionary measures. It is necessary to remember that treatment by electric current can cause local reactions of irritation of skin. Therefore it is necessary to observe carefully the instruction of producers of devices that use of the drug Dolobene did not strengthen these local reactions. It is always necessary to pay attention to sufficiency of a covering of electrodes a damp sponge.
Dolobene and ultrasound (fonororez)
This drug is good contact gel at therapy by ultrasound (fonoforez). Active ingredients of gel (dimethyl sulfoxide and heparin) supplement therapeutic action of ultrasonic waves.

Side effects
Very often
When drawing on big sites of skin can appear complaints from digestive tract in the form of indigestion, nausea. diarrheas
- local skin reactions (reddening, blisters, an erythema, an itching and burning sensation), a photosensitization
- urticaria and a Quincke's edema
- a garlic smell from a mouth, change of flavoring feelings which disappear in a few minutes
Very seldom
When drawing on big sites of skin can develop complaints to heart, breath, fatigue, a headache,

the Contraindication fever
- hypersensitivity to one of gel components
- heavy abnormal liver functions and/or kidneys
- bronchial asthma
- the significant disturbances of a cardiovascular system (heavy stenocardia, a myocardial infarction, a stroke, the profound general atherosclerosis)
- pregnancy, the lactation period
- children's age up to 5 years.
Drug cannot be applied on mucous membranes (eyes, a nose, a mouth), open wounds or on the injured skin (for example, a state after radiation or heavy sunblisters, fresh postoperative hems).

Medicinal interactions
At simultaneous use of Dolobene gel and:
- other medicines their permeability through skin locally amplifies
- the medicines containing anti-inflammatory drug Sulindac (non-steroidal anti-inflammatory drug) emergence of heavy toxic reactions (peripheral neuropathy) is possible.

Special instructions
It is necessary to avoid reception of solar bathtubs and a sunbed during Dolobene's treatment.
Pregnancy and feeding by a breast
drug Dolobene Use gel during pregnancy contraindicated in connection with insufficient experience of use of a dimethyl sulfoxide for pregnant women.
The dimethyl sulfoxide gets into maternal milk therefore use of this drug during feeding by a breast contraindicated.
Features influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
does not influence

Due to the low system absorbability of active agents the overdose is improbable.

A release form
On 20 g or 50 g of drug in aluminum tubas with the screwing-up cover.
On 1 tuba together with the instruction for medical use in the state and Russian languages put in a box of cardboard.

To Store storage conditions at a temperature not above 25 °C.
To store out of children's reach!

3 years
not to apply a period of storage after an expiration date!

Prescription status
Without prescription

Merkle GmbH Producer, Germany

the Packer
of Merkle GmbH, Germany

the Owner of the registration certificate
ratiopharm GmbH, Germany

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) of ratiopharm Kazakhstan LLP, 050040, Almaty, Al-Farabi Ave., 19, BC Nurly-Tau, 1B, office 603, phone number: (727) 311 09 15, Fax: (727) 311 07 34 e-mail:

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