DECARIS (Levamisole) 50 mg, 2 tablets
- $7.60
One tablet contains the active substance - levamisole hydrochloride 59 mg (equivalent to levamisole 50 mg),
Excipients: corn starch, sodium saccharin, talc, povidone, apricot flavor, magnesium stearate, sunset yellow (E 110).
Levamisole is rapidly absorbed from the gastrointestinal tract. The maximum plasma concentration is determined on average 1.5-2 hours after administration.
Levamisole is extensively metabolized in the liver, its main metabolites are p-hydroxy-levamisole and its glucuronide derivative.
The elimination half-life from the body is 3-6 hours. Less than 5% is excreted unchanged in the urine, less than 0.2% of the administered dose with feces.
Decaris refers to antihelminthic drugs. The mechanism of anthelmintic action is based on specific inhibition of succinate dehydrogenase, which causes blocking of the most important fumarate reduction reaction for nematodes and disruption of the course of bioenergetic processes in helminths. Paralyzed worms are excreted from the body, thanks to normal intestinal peristalsis, 24 hours after taking the drug.
- ascariasis (Ascaris lumbricoides)
- necatorosis (Necator americanus)
- hookworm (Ancylostoma duodenale).
Adults: 3 tablets of 50 mg (150 mg) taken as a single dose, preferably in the evening, after meals with a small amount of water.
Reception of laxatives and compliance with a special diet is not required.
If necessary, treatment can be repeated after a 7-14-day break.
- headache, insomnia, dizziness
- increased heartbeat
- convulsions
- nausea, vomiting, abdominal pain, diarrhea
- allergic skin reactions
Rarely
- encephalopathy 2-5 weeks after treatment
Maybe
- leukopenia, agranulocytosis with prolonged use of large doses.
- hypersensitivity to any of the components of the drug
- simultaneous reception with lipophilic agents, for example,
with carbon tetrachloride, tetrachlorethylene, chenopodium oil, chloroform and ether
- alcohol intake, during and after treatment, during the first 24 hours
- children's age up to 18 years
- pregnancy and lactation
When taken simultaneously with coumarin anticoagulants, dose adjustment of the oral anticoagulant is required, since the prothrombin time may be lengthened. Care must be taken when prescribing simultaneously with drugs that affect hematopoiesis.
Decaris can increase the level of phenytoin in the blood plasma, therefore, with their simultaneous use, it is necessary to control the level of phenytoin in the blood.
In the process of treatment with Decaris, a blood test should be periodically performed (at least 1 time in 3 weeks).
In most cases, encephalopathy is reversible and early use of corticosteroids improves the condition. The presence of a causal relationship with the reception of Decaris could not be established.
Application in pediatrics
The drug Decaris is not used in patients under 18 years of age due to the content of the dye "sunset yellow".
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
While taking the drug, slight and short-term dizziness is possible, so care should be taken while driving a car and performing work associated with an increased risk of injury.
Symptoms: nausea, vomiting, diarrhea, dizziness, lethargy, convulsions after large (> 600 mg) doses.
Treatment: gastric lavage, symptomatic therapy. In case of overdose, atropine can be prescribed as an antidote.
Store at temperatures between 15°C and 25°C.
Keep out of the reach of children!
Shelf life - 5 years
Do not use after the expiry date!
Excipients: corn starch, sodium saccharin, talc, povidone, apricot flavor, magnesium stearate, sunset yellow (E 110).
Pharmacological properties
Pharmacokinetics
Levamisole is rapidly absorbed from the gastrointestinal tract. The maximum plasma concentration is determined on average 1.5-2 hours after administration.
Levamisole is extensively metabolized in the liver, its main metabolites are p-hydroxy-levamisole and its glucuronide derivative.
The elimination half-life from the body is 3-6 hours. Less than 5% is excreted unchanged in the urine, less than 0.2% of the administered dose with feces.
Pharmacodynamics
Decaris refers to antihelminthic drugs. The mechanism of anthelmintic action is based on specific inhibition of succinate dehydrogenase, which causes blocking of the most important fumarate reduction reaction for nematodes and disruption of the course of bioenergetic processes in helminths. Paralyzed worms are excreted from the body, thanks to normal intestinal peristalsis, 24 hours after taking the drug.
Indications for use
- ascariasis (Ascaris lumbricoides)
- necatorosis (Necator americanus)
- hookworm (Ancylostoma duodenale).
Dosage and administration
Adults: 3 tablets of 50 mg (150 mg) taken as a single dose, preferably in the evening, after meals with a small amount of water.
Reception of laxatives and compliance with a special diet is not required.
If necessary, treatment can be repeated after a 7-14-day break.
Side effects
- headache, insomnia, dizziness
- increased heartbeat
- convulsions
- nausea, vomiting, abdominal pain, diarrhea
- allergic skin reactions
Rarely
- encephalopathy 2-5 weeks after treatment
Maybe
- leukopenia, agranulocytosis with prolonged use of large doses.
Contraindications
- hypersensitivity to any of the components of the drug
- simultaneous reception with lipophilic agents, for example,
with carbon tetrachloride, tetrachlorethylene, chenopodium oil, chloroform and ether
- alcohol intake, during and after treatment, during the first 24 hours
- children's age up to 18 years
- pregnancy and lactation
Drug Interactions
When taken simultaneously with coumarin anticoagulants, dose adjustment of the oral anticoagulant is required, since the prothrombin time may be lengthened. Care must be taken when prescribing simultaneously with drugs that affect hematopoiesis.
Decaris can increase the level of phenytoin in the blood plasma, therefore, with their simultaneous use, it is necessary to control the level of phenytoin in the blood.
Special instructions
In the process of treatment with Decaris, a blood test should be periodically performed (at least 1 time in 3 weeks).
In most cases, encephalopathy is reversible and early use of corticosteroids improves the condition. The presence of a causal relationship with the reception of Decaris could not be established.
Application in pediatrics
The drug Decaris is not used in patients under 18 years of age due to the content of the dye "sunset yellow".
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
While taking the drug, slight and short-term dizziness is possible, so care should be taken while driving a car and performing work associated with an increased risk of injury.
Overdose
Symptoms: nausea, vomiting, diarrhea, dizziness, lethargy, convulsions after large (> 600 mg) doses.
Treatment: gastric lavage, symptomatic therapy. In case of overdose, atropine can be prescribed as an antidote.
Storage conditions
Store at temperatures between 15°C and 25°C.
Keep out of the reach of children!
Shelf life - 5 years
Do not use after the expiry date!
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