Cortexin® 10 mg/5 mg

  • $43.00
Sku: e69728ac6e71
Ingredient: Polypeptide complex
Cas No.: 83270-84-2
ATC Code: N06BX

What is Cortexin?

Cortexin® is a nootropic medication derived from the brain cortex of cattle. It is available as a lyophilized powder for the preparation of an intramuscular injection solution. This medication contains water-soluble polypeptide fractions that directly target nerve cells, offering neuroprotective, antioxidant, and tissue-specific effects.

How Does Cortexin Work?

Cortexin® works by delivering a complex of low-molecular-weight, water-soluble polypeptides through the blood-brain barrier to the neurons. This action enhances brain functions such as learning, memory, and concentration while providing protection to neurons against various neurotoxic factors. It also reduces the toxic effects of psychotropic substances, inhibits lipid peroxidation in neurons, and boosts neuron survival under oxidative stress and hypoxia.

What Are the Benefits of Cortexin?

Cortexin® offers several therapeutic benefits:

  • Nootropic Effects: Improves cognitive functions, learning processes, and memory.
  • Neuroprotective Effects: Shields neurons from damage caused by endogenous neurotoxic factors like glutamate and free radicals.
  • Antioxidant Effects: Inhibits lipid peroxidation in neurons and enhances their survival during oxidative stress.
  • Tissue-Specific Effects: Activates the metabolism of neurons in the central and peripheral nervous systems, aiding in repair processes and overall brain function.

How Does Cortexin Help Children with ADHD?

Cortexin® has demonstrated significant effectiveness in children with Attention Deficit Hyperactivity Disorder (ADHD). The peptide-based bioregulator improves metabolic processes in the brain and selectively acts on brain cells. Clinical improvements observed in children with ADHD include:

  • Increased attentiveness and reduced distractions during school activities.
  • Faster completion of tasks and improved academic performance.
  • Enhanced fine motor skills and neuropsychological test results.

Children with speech impairments also benefit greatly from Cortexin®. They show a greater willingness to use speech for communication, repeat after adults, and exhibit an expanded active vocabulary. Improvements in understanding spoken language and reducing grammatical errors are noted as well. Parents report decreased asthenic symptoms, such as improved emotional attention and perseverance.

What is the Mechanism of Action of Cortexin?

The mechanism of action of Cortexin® involves:

  • Activation of neuronal peptides and brain neurotrophic factors.
  • Optimization of the balance of excitatory and inhibitory amino acids, dopamine, and serotonin.
  • GABAergic effects.
  • Reduction of paroxysmal seizure activity in the brain.
  • Improvement of bioelectrical activity of the brain.
  • Prevention of free radical formation (products of lipid peroxidation).

What is the Composition of Cortexin?

Cortexin® is available in two formulations, one for adults and one for children:

Adult Formulation:

  • Active Ingredient: Cortexin 10 mg (a complex of water-soluble polypeptide fractions).
  • Excipient: Glycine 12 mg (stabilizer).

Pediatric Formulation:

  • Active Ingredient: Cortexin 5 mg (a complex of water-soluble polypeptide fractions).
  • Excipient: Glycine 6 mg (stabilizer).

Amino Acid Composition (nmol/10 mg)

L-Amino Acids

    • Aspartic Acid: 446
    • Threonine: 212
    • Serine: 268
    • Glutamic Acid: 581
    • Proline: 187
    • Glycine: 298
    • Alanine: 346
    • Valine: 240
    • Methionine: 0
    • Isoleucine: 356
    • Tyrosine: 109
    • Phenylalanine: 162
    • Histidine: 116
    • Lysine: 253
    • Arginine and Other Amino Acids: 202

    Vitamin Composition (mcg/10 mg)

    • Thiamine (B1): 0.08
    • Riboflavin (B2): 0.03
    • Niacin (PP): 0.05
    • Retinol (A): 0.011
    • Alpha-Tocopherol (E): 0.007

    Mineral Composition (mcg/10 mg)

    • Copper: 0.2129
    • Iron: 2.26
    • Calcium: 22.93
    • Magnesium: 8.5
    • Potassium: 19.83
    • Sodium: 643.2
    • Sulfur: 152.65
    • Phosphorus: 91.95
    • Zinc: 4.73
    • Molybdenum: 0.0203
    • Cobalt: 0.0044
    • Manganese: 0.0061
    • Selenium: 0.0745
    • Aluminum: 0.3104
    • Lithium: 0.0340

    How is Cortexin Administered?

    Cortexin® is administered intramuscularly. The lyophilized powder in the vial should be dissolved in 1-2 ml of 0.5% procaine (novocaine), water for injection, or 0.9% sodium chloride solution. The injection should be given daily as follows:

    • Adults: 10 mg daily for 10 days.
    • Children: For body weight up to 20 kg, 0.5 mg/kg; for body weight over 20 kg, 10 mg daily for 10 days.

    A repeat course can be administered after 3-6 months if necessary. For children with ADHD, the same dosage regimen is recommended, either as monotherapy or in combination with other symptomatic and pathogenetic treatments for central nervous system disorders.

    What Are the Possible Side Effects of Cortexin?

    Like any medication, Cortexin® can cause side effects, although not everyone experiences them. Possible adverse reactions include:

    • Immune System Disorders: Anaphylactic shock, angioneurotic edema, skin rash, itching, and redness.
    • General Disorders: Redness at the injection site.
    • Nervous System Disorders: Psychomotor agitation, coordination disorders, and insomnia.
    • Cardiac Disorders: Tachycardia (increased heart rate).
    • Psychiatric Disorders: Anxiety.

    Are There Any Special Precautions?

    • When using procaine (novocaine) as a solvent, follow the specific precautions and contraindications provided in the procaine instructions.
    • Do not use lidocaine as a solvent for preparing the Cortexin® solution in children due to an increased risk of adverse reactions.
    • Do not store or use the dissolved solution after preparation.
    • Do not mix the Cortexin® solution with other solutions.
    • If a dose is missed, do not double the next dose; continue with the next scheduled injection.
    • Use Cortexin® only as directed by a healthcare professional.

    Storage and Handling Instructions

    Store Cortexin® in a light-protected place at a temperature not exceeding 25°C (77°F). Keep out of reach of children. Do not use after the expiration date indicated on the packaging.

    What Should You Do in Case of an Overdose?

    There have been no reported cases of Cortexin® overdose. However, always adhere to the prescribed dosage and consult a healthcare provider if you suspect an overdose or experience any adverse effects.

    Scientific Studies

    Write a review
    Related Products
    Egis (Hungary)
    GRANDAXIN® (Tofisopam) 50 mg x 20 / 60 Tabs
    OlainFarm (Latvia)
    Adaptol® (Adaptolum, Mebicarum) 500 mg, 20 tablets
    Bioterra (Belarus)
    Ginkgo biloba + glycine (30 tablets)
    Out Of Stock
    Abdi Ibrahim (Turkey)
    Cytological 28's 20 mg film-coated tablets
    EVER Pharma Jena GmbH (Germany)
    Cerebrolysin® 5ml x 5 ampoules
    Soik LLC (Russia)
    Sophora + vitamins for vessels (30 capsules)
    Labomar srl. (Italy)
    Kalmavis (30 coated tablets)