Clotrimazole 1% 25g Ointment
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The instruction
for medical use of medicine
Clotrimazolum
the Trade name
Clotrimazolum
the International unlicensed
name Clotrimazolum Dosage Form 1% Ointment Structure of 1 G of Ointment contains
active agent - Clotrimazolum (in terms of 100% dry matter) 10 mg,
excipients: propylene glycol, polyethyleneglycol 400, proksanol 268, cetostearyl alcohol, polyethyleneglycol cetostearyl ether.
The description
Ointment of white color, uniform consistence with a slight specific smell.
Pharmacotherapeutic group
Antifungal drugs for topical administration. Imidazole derivatives. Clotrimazolum.
The ATX D01A C01 code
the Pharmacological
Pharmacokinetics Drug properties has high penetration. At external use the concentration of drug in epidermis is higher, than in a derma and hypodermic cellulose. Practically it is not absorbed in a system blood stream.
The pharmacodynamics
Antifungal means from group of derivatives of an imidazole for external use, reduces synthesis of the ergosterol which is a component of a cellular membrane of mushrooms and leads to change of its structure and properties. In small concentration works fungistaticly, and in big it is fungicidal, and not only on proliferating cells. In fungicide concentration interacts with mitochondrial and peroksidazny enzymes of a fungal cell therefore there is an increase in concentration of peroxide of hydrogen up to toxic level that promotes destruction of fungal cells. It is active in relation to pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), to barmy and mold mushrooms of the sort Candida, Torulopsis glabrata, the sort Rhodotorula, activators multi-colored depriving (Malassezia furfur), an erythrasma (Corynebacterium minutissimum), to gram-positive microorganisms (Staphylococcus spp., Streptococcus spp.).
Indications
- fungus diseases of skin, mycoses of skin folds, feet
- the chromophytosis, an erythrasma, superficial candidiases caused by dermatophytes, barmy (including the sort Candida), the mold and other mushrooms and activators sensitive to Clotrimazolum
- the mycoses complicated by a secondary pyoderma.
Route of administration and doses
Outwardly. Ointment is applied a thin layer by 2-3 times a day on previously cleaned (with the use of soap with neutral value rn) dry affected areas of skin and carefully rub.
Duration of treatment depends on disease severity, localization of pathological changes and efficiency of therapy.
Treatment of dermatomycoses is carried out by not less than 4 weeks, a chromophytosis of-1-3 weeks.
In fungus diseases of skin of legs the therapy is recommended to be continued within not less than 2 weeks after elimination of symptoms of a disease.
Side effects
Seldom
- reddening, burning sensation, an itching, irritation and peeling of skin
- allergic reactions
of the Contraindication
- hypersensitivity to Clotrimazolum or other components of drug
- children's age up to 14 years
Medicinal interactions
Dexamethasone in high doses slows down antifungal effect of drug.
Amphotericinum B, nystatin, natamitsin reduce efficiency of Clotrimazolum at simultaneous use.
At ointment use the negative interactions with other means are not known and they should not be expected as rezorbtsionny ability of Clotrimazolum very low.
The special
instructions Drug it is not used in ophthalmologic practice.
Drug should not be applied on mucous membranes.
At emergence of signs of hypersensitivity or irritation the treatment should be stopped.
If symptoms of a disease do not disappear within 4 weeks of use of drug, it is necessary to specify the diagnosis.
Pregnancy and period of a lactation.
During pregnancy and feeding by a breast it is necessary to use drug with care if the advantage for mother exceeds potential risk for a fruit or the child.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms.
Use of drug does not affect ability of the patient to control of the vehicle or potentially dangerous mechanisms.
The overdose
is not revealed
the Form of release and packing
On 25 g in tubas aluminum from bushona with internal coating is delicious.
Each tuba together with the instruction for medical use in the state and Russian languages is placed in a pack from cardboard.
To Store storage conditions in original packing at a temperature not over 25 With, freezing is not allowed.
To store out of children's reach!
2 years
not to apply a period of storage after the expiry date specified on packing.
Prescription status
Without prescription
the Borshchagovsky Research and production center Public joint stock company Producer the chemical and pharmaceutical plant,
03134, Ukraine, Kiev, Mira St. 17.
The owner of the registration certificate
the Borshchagovsky Research and production center Public joint stock company the chemical and pharmaceutical plant, Ukraine
the Address of the organization accepting claims in the territory of RK from consumers on quality
of the Representative Office of PJSC NPC product Borshchagovsky of HFZ in the territory of the Republic of Kazakhstan
050043, Almaty, mdt. Orbit-2, 28, quarter 30
Fax: +7 (272) 20-78-05, 55-18-53
E-mail: vadimt58@list.ru
for medical use of medicine
Clotrimazolum
the Trade name
Clotrimazolum
the International unlicensed
name Clotrimazolum Dosage Form 1% Ointment Structure of 1 G of Ointment contains
active agent - Clotrimazolum (in terms of 100% dry matter) 10 mg,
excipients: propylene glycol, polyethyleneglycol 400, proksanol 268, cetostearyl alcohol, polyethyleneglycol cetostearyl ether.
The description
Ointment of white color, uniform consistence with a slight specific smell.
Pharmacotherapeutic group
Antifungal drugs for topical administration. Imidazole derivatives. Clotrimazolum.
The ATX D01A C01 code
the Pharmacological
Pharmacokinetics Drug properties has high penetration. At external use the concentration of drug in epidermis is higher, than in a derma and hypodermic cellulose. Practically it is not absorbed in a system blood stream.
The pharmacodynamics
Antifungal means from group of derivatives of an imidazole for external use, reduces synthesis of the ergosterol which is a component of a cellular membrane of mushrooms and leads to change of its structure and properties. In small concentration works fungistaticly, and in big it is fungicidal, and not only on proliferating cells. In fungicide concentration interacts with mitochondrial and peroksidazny enzymes of a fungal cell therefore there is an increase in concentration of peroxide of hydrogen up to toxic level that promotes destruction of fungal cells. It is active in relation to pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), to barmy and mold mushrooms of the sort Candida, Torulopsis glabrata, the sort Rhodotorula, activators multi-colored depriving (Malassezia furfur), an erythrasma (Corynebacterium minutissimum), to gram-positive microorganisms (Staphylococcus spp., Streptococcus spp.).
Indications
- fungus diseases of skin, mycoses of skin folds, feet
- the chromophytosis, an erythrasma, superficial candidiases caused by dermatophytes, barmy (including the sort Candida), the mold and other mushrooms and activators sensitive to Clotrimazolum
- the mycoses complicated by a secondary pyoderma.
Route of administration and doses
Outwardly. Ointment is applied a thin layer by 2-3 times a day on previously cleaned (with the use of soap with neutral value rn) dry affected areas of skin and carefully rub.
Duration of treatment depends on disease severity, localization of pathological changes and efficiency of therapy.
Treatment of dermatomycoses is carried out by not less than 4 weeks, a chromophytosis of-1-3 weeks.
In fungus diseases of skin of legs the therapy is recommended to be continued within not less than 2 weeks after elimination of symptoms of a disease.
Side effects
Seldom
- reddening, burning sensation, an itching, irritation and peeling of skin
- allergic reactions
of the Contraindication
- hypersensitivity to Clotrimazolum or other components of drug
- children's age up to 14 years
Medicinal interactions
Dexamethasone in high doses slows down antifungal effect of drug.
Amphotericinum B, nystatin, natamitsin reduce efficiency of Clotrimazolum at simultaneous use.
At ointment use the negative interactions with other means are not known and they should not be expected as rezorbtsionny ability of Clotrimazolum very low.
The special
instructions Drug it is not used in ophthalmologic practice.
Drug should not be applied on mucous membranes.
At emergence of signs of hypersensitivity or irritation the treatment should be stopped.
If symptoms of a disease do not disappear within 4 weeks of use of drug, it is necessary to specify the diagnosis.
Pregnancy and period of a lactation.
During pregnancy and feeding by a breast it is necessary to use drug with care if the advantage for mother exceeds potential risk for a fruit or the child.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms.
Use of drug does not affect ability of the patient to control of the vehicle or potentially dangerous mechanisms.
The overdose
is not revealed
the Form of release and packing
On 25 g in tubas aluminum from bushona with internal coating is delicious.
Each tuba together with the instruction for medical use in the state and Russian languages is placed in a pack from cardboard.
To Store storage conditions in original packing at a temperature not over 25 With, freezing is not allowed.
To store out of children's reach!
2 years
not to apply a period of storage after the expiry date specified on packing.
Prescription status
Without prescription
the Borshchagovsky Research and production center Public joint stock company Producer the chemical and pharmaceutical plant,
03134, Ukraine, Kiev, Mira St. 17.
The owner of the registration certificate
the Borshchagovsky Research and production center Public joint stock company the chemical and pharmaceutical plant, Ukraine
the Address of the organization accepting claims in the territory of RK from consumers on quality
of the Representative Office of PJSC NPC product Borshchagovsky of HFZ in the territory of the Republic of Kazakhstan
050043, Almaty, mdt. Orbit-2, 28, quarter 30
Fax: +7 (272) 20-78-05, 55-18-53
E-mail: vadimt58@list.ru
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