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Description
The instruction for medical use of medicine Wobenzym plus the Trade name Wobenzym plus the International unlicensed name Is not present the Dosage form of the Tablet, covered with a kishechnorastvorimy cover Structure One tablet contains active agents: bromelain – 450 F.I.P. – PIECE trypsin – 1440 F.I.P. – PIECE (24 μkat) rutoside trihydrate – 100 mg, excipients: lactoses monohydrate, starch prezhelatinizirovanny, magnesium stearate, stearic acid 70, silicon dioxide colloidal anhydrous, talc. structure of a cover: the macrogoal 6000, methacrylic acid – methyl acrylate methyl a kopolimer (1:1), talc, trietit citrate, vanillin. The description of the Tablet of round shape, with a biconvex and smooth surface, film coated yellowish-green color. Pharmacotherapeutic group Other therapeutic ATX V03A Code Pharmacological Pharmacokinetics Absorption Properties products and distribution: The big molecular substances, such as enzymes which are contained in Wobenzym plus are soaked up from digestive tract under the influence of various cell-mediated mechanisms and contact transport blood proteins (alpha 1 – antitrypsin, alpha 2 – macroglobulin). After oral administration of enzymes are observed good correlation between plasma concentration of trypsin or a bromelain and the accepted dose. Therapeutic concentration are reached within 4 days of administration of drug. Active agents in a complex transport blood proteins (alpha 1 – antitrypsin, alpha 2 – macroglobulin) contact cellular receptors and in the subsequent are removed by means of the system of mononuclear phagocytes and also other mechanisms. Not absorbed hydrolases and rutoside are removed from an organism with a stake provided that they are not denatured and are not digested. The pharmacodynamics Wobenzym plus improves a functional condition of blood cells and a vascular wall, reduces viscosity of blood and risk of formation of blood clots in vessels, promotes dissolution of already formed blood clots. Enzymes bromelain, trypsin and rutoside have the impact on swell inflammatory and noninflammatory origin (damage of soft tissues, sports injuries), the pain syndrome as a result decreases that is explained by direct proteolysis of mediators of inflammation the enzymes which are a part of Wobenzym plus, and also by reduction of oncotic pressure in the inflammation center. It leads to reduction of hypostasis, tension of fabrics and pressure upon nerve terminations. Wobenzym plus improves microcirculation in the inflammation centers, increases delivery of oxygen and nutrients (blood supply), stimulating with that reparative processes in chronic diseases and in the postoperative period. Wobenzym plus improves blood supply of bronchial tubes and pulmonary fabric in chronic respiratory diseases, dilutes a phlegm, improves function of a ciliary epithelium and restores drainage function of bronchial tubes. At tests of enzymes bromelain and trypsin, in the conditions of in vitro and in vivo, it is shown their inhibiting influence on formation (pathogenic) cell-bound immune complexes, activation of not triggered mononuclear triggered cells and decrease in an expression of adhesive molecules (for example, CD 44, CD 54 also known as ICAM – 1). Wobenzym plus increases efficiency of antibiotics by improvement of microcirculation and blood supply in the inflammation center. Wobenzym plus does not replace treatment with antibiotics of infectious inflammation, but increases their efficiency. Indications In complex therapy: – posttraumatic and postoperative hypostases – lymphatic hypostases and microcirculator disorders – phlebitis, a posttrombotichesky syndrome (a state after repeated inflammation of veins), trophic ulcers, – acute and chronic inflammations of an urinogenital path at men: cystitis, an urethritis, tsistopiyelit, prostatitis, – acute and chronic inflammatory diseases of bodies of a small pelvis at women: an adnexitis, a salpingo-oophoritis, – a pseudorheumatism, rheumatism of soft tissues (for example: muscular rheumatism, a syndrome of a tennis elbow or a lateral epicondylitis, a syndrome of the frozen shoulder or an adhesive capsulitis of a shoulder joint, a tendovaginitis), degenerative diseases of joints and a backbone. It can be used at adults and children of 6 years. To accept a route of administration and doses of the Tablet inside, not less than in 30 minutes prior to food, without chewing, washing down with water (200 ml). Adults With the medical purpose accept 3 tablets 3 times a day within 2 weeks. In special cases (a serious illness, acute inflammations, after injuries and during the postoperative period when fast stopping of hypostasis is necessary, bruises and hemorrhages) the maximum recommended dose makes 12 tablets a day divided into three receptions. It is recommended to apply to prevention in a dosage on 2 tablets 3 times a day within 2 weeks. Children to Children from 6 to 12 years – on 10 kg of weight of the child 1 tablet a day. This dose has to be divided into two or three receptions. Since 12 years according to the scheme for adults. Change of course of reception and dosages of drug perhaps only after consultation with the doctor. Side effects increase of a chair change of consistence and a smell the calla which are quickly stopped a privremenny dose decline of drug occasionally can arise allergic reaction (skin rash, an itching), kotorayaischezat after the drug treatment termination – nausea, a meteorism, an abdominal pain, a headache, a dieback, the general weakness – feeling of overpopulation of intestines. It it is possible to prevent, a razdelivdnevny dose on bigger quantity of single doses of the Contraindication individual intolerance the congenital or acquired disturbances of blood clotting (for example, hemophilia) – children’s age up to 6 years Medicinal interactions of Cases of incompatibility with other medicines it was not noted acute diseases of a liver. Wobenzym use plus together with antibiotics increases efficiency of antibiotic treatment. Special instructions in case of infectious processes Wobenzym plus does not replace antibiotics. In case of exacerbation of a disease at intake of Wobenzym plus is recommended a temporary dose decline and it is necessary to see a doctor. Carrying out a hemodialysis is possible only after consultation with the doctor. The patients having diabetes should consider that each tablet of drug contains 0.015 grain units. Pregnancy and a lactation At pregnancy apply with care, only in cases when the expected advantage of therapy for mother exceeds potential risk of emergence of side effects at a fruit (only after consultation with the doctor!) Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Drug is not doping and has no negative impact on driving of the car and performance of work, the mental and physical reactions demanding high speed. Overdose of Cases of overdose of drug it is unknown. The form of release and packing On 20 tablets place in blister strip packaging from a film of polyvinylchloride and aluminum foil and/or from a film of polyvinylchloride, polyethylene and aluminum foil On 2 or 10 planimetric packs together with the instruction for medical use in the state and Russian languages put in a cardboard pack. To Store storage conditions in the dry place, at a temperature from 15 °C to 25 °C. To store out of children’s reach! 2 years After the expiration date specified on packing not to use a period of storage! Prescription status Without prescription of Proizvoditel MUKOS Emulsions GmbH, Germany. D-13509 Berlin, Germany the Owner of the registration certificate of MUKOS of Pharm of CZ of neuter of the lake, Prukhones, the Czech Republic the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) and responsible for post-registration observation of safety of medicine. Representation of MUCOS Pharma CZ SRO in Republic of Kazakhstan. 050026, Republic of Kazakhstan, Almaty, Muratbayev St. 62, office 68,
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