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Neurox 50mg / 5ml 5’s ml solution for injection in ampoules intravenously and intramuscularly.




The instruction for medical use

of Neuroks Torgovoye medicine a name
of Neuroks

the International unlicensed name
Is not present

the Dosage form
Solution for intravenous and intramuscular administration 50 mg/ml, 2 ml and 5 ml

One ampoule contains
active agent – ethylmethylhydroxypyridine succinate of 100 mg, 250 mg,
excipients: sodium disulphite, water for injections.

The description
Transparent colourless or slightly yellowish liquid

Pharmacotherapeutic group
Drugs for treatment of diseases of nervous system other
Drugs for treatment of diseases of nervous system other
the ATX N07XX Code

the Pharmacological

Pharmacokinetics At properties intramuscular introduction drug is defined in blood plasma for 4 h after introduction. Time of achievement of the maximum concentration at intramuscular introduction – 0.3-0.58 h. The maximum concentration at intramuscular introduction in a dose of 400-500 mg – 2.5-4 mkg/ml. Etilmetilgidroksipiridina quickly passes succinate from the blood course into bodies and fabrics and is quickly brought from an organism. Time of deduction (MRT) of drug in an organism at intramuscular introduction – 0.7-1.3 h. It is metabolized in a liver by a glyukuronirovaniye. It is quickly removed with urine, generally in the form of metabolites (50% for 12 h) and in insignificant quantity – in not changed look (0.3% for 12 h). It is most intensively removed during the first 4 h after administration of drug. Removal indicators with urine of not changed drug and metabolites have considerable individual variability.
The pharmacodynamics
of Neuroks is the inhibitor of free radical processes, a membranoprotektor possessing anti-hypoxemic, antistress, nootropic, anticonvulsant and anxiolytic action. Belongs to class 3 of oxypyridines. The mechanism of action is caused antioxidant and membranoprotektorny by properties. Suppresses peroxide oxidation of lipids, increases activity of a superoksidoksidaza, the lipid protein raises a ratio, improves structure and function of a cell membrane. Modulates activity of membrane-bound enzymes, receptor complexes that promotes their linking with ligands, preservation of the structurally functional organization of membranes, transport of neurotransmitters and improvement of synoptic transfer. Increases concentration in a dopamine brain. Strengthens compensatory activation of aerobic glycolysis and reduces extent of oppression of oxidizing processes in a tricarbonic acid cycle in the conditions of a hypoxia with increase in adenosine triphosphoric acid and creatine phosphate, activates the power synthesizing function of mitochondrions. Increases resistance of an organism to influence of various disturbing factors at morbid conditions (shock, a hypoxia and ischemia, disturbances of cerebral circulation, intoxication ethanol and antipsychotic medicines). Improves metabolism and blood supply of a brain, microcirculation and rheological properties of blood, reduces aggregation of thrombocytes. Stabilizes blood cell membranes (erythrocytes and thrombocytes), reducing a hemolysis likelihood of development. Possesses hypolipidemic action, reduces the content of the general cholesterol and lipoproteins of low density.
Neuroks improves a clinical course of a myocardial infarction, reduces a necrosis zone, restores and/or improves electric activity and contractility of a myocardium and also increases a coronary blood stream in an ischemia zone, increases anti-anginal activity of nitrodrugs, reduces consequences of a reperfusion syndrome at acute coronary insufficiency due to normalization of metabolic processes in an ischemic myocardium.
Antistress action is shown in normalization of a post-stressful state (fear, alarm, tension and concern and so forth), the broken processes of training and memory, decrease in dystrophic changes in various structures of a brain, disorders of somatic and vegetative nervous systems (weakness, perspiration, feeling of alarm, a headache, tachycardia, disturbance of the cycles dream wakefulness and so forth).
Neuroks possesses anti-toxic action in an abstinence syndrome, eliminates neurologic and neurotoxic manifestations of an acute drunkenness, adjusts behavioural and cognitive disturbances. Under the influence of Neuroks the action tranquilizing, antipsychotic, antidepressive amplifies, hypnotic drugs and anticonvulsants that allows to lower their doses and to reduce side effects.

– acute disorders of cerebral circulation (as a part of complex therapy)
– a craniocereberal injury, consequences of craniocereberal injuries
– distsirkulyatorny encephalopathy
– vegetative (neurocirculatory) dystonia
– slight cognitive disorders of atherosclerotic genesis
– disturbing states at neurotic and neurosis-like states
– an acute myocardial infarction (since the first day) as a part of complex therapy
– primary open angle glaucoma of various stages, as a part of complex therapy
– an abstinence syndrome in alcoholism with prevalence of neurosis-like and vegetovascular disorders
– acute intoxication antipsychotic medicines

the Route of administration and doses
Intramusculary (in oil) or intravenously (in / c) (struyno or by drop infusion). At an infusional method of administration drug should be dissolved in 0.9% chloride sodium solution.
Struyno Neuroks is entered slowly within 5-7 min., by drop infusion – with a speed of 40-60 thaws a minute. The maximum daily dose should not exceed 1200 mg.
In acute disorders of cerebral circulation of Neuroks apply in complex therapy in the first 10-14 days – in/in by drop infusion 200-500 mg 2-4 times a day, then – 2-3 times, in oil on 200-250 mg, a day within 2 weeks.
In a craniocereberal injury and consequences of craniocereberal injuries of Neuroks apply within 10-15 days in/in by drop infusion 200-500 mg 2-4 times a day.
In distsirkulyatorny encephalopathy in a phase of a decompensation of Neuroks it is necessary to appoint in/in struyno or by drop infusion in a dose of 200-500 mg 1-2 times a day within 14 days. Then – in oil on 100-250 mg/days within the next 2 weeks.
For course prevention of distsirkulyatorny encephalopathy of Neuroks enter in oil 2 once in a dose of 200-250 mg a day within 10-14 days.
In neurocirculatory dystonia, neurotic and neurosis-like states the drug is administered in oil on 50-400 mg a day within 14 days.
At easy cognitive disturbances at patients of advanced age and in anxiety disorders drug is used by in oil 100-300 mg in a dose a day within 14-30 days.
In an acute myocardial infarction as a part of complex therapy of Neuroks enter in/in or in oil within 14 days, against the background of the traditional therapy of a myocardial infarction (including nitrates, beta blockers, inhibitors of the angiotensin-converting enzyme (ACE), a trombolitika, anticoagulating and antiagregantny drugs and also symptomatic means according to indications).
In the first 5 days Neuroks is entered intravenously, in the next 9 days the drug can be administered intramusculary.
Intravenous administration of drug is made by drop infusion (slowly) within 30-90 minutes (in 100-150 ml of 0.9% of solution of sodium of chloride or 5% of solution of a dextrose (glucose)), if necessary perhaps slow jet in/in administration of drug, lasting not less than 5 minutes.
Administration of drug (in/in or in oil) is carried out by 3 times a day, every 8 hours. The daily dose makes 6-9 mg/kg of body weight, a single dose – 2-3 mg/kg of body weight. The maximum daily dose should not exceed 800 mg, single – 250 mg.
In an open angle glaucoma of various stages as a part of complex therapy of Neuroks enter in oil 100-300 mg/days, 1-3 times a day within 14 days.
In an abstinence alcoholic syndrome of Neuroks enter in oil or in/in by drop infusion in a dose of 200-500 mg 2-3 times a day within 5-7 days.
In acute intoxication antipsychotic medicines of Neuroks enter in/in in a dose of 200-500 mg/days within 7-14 days.

Side effects
– dryness in a mouth, metal smack in a mouth, an unpleasant smell, irritation in a throat, feelings of the spreading heat in all body, discomfort in a thorax, feeling of shortage of air (as a rule, are connected with excessively high rate of administering and have short-term character)
– nausea, a meteorism
– drowsiness, backfilling disturbance
– allergic reactions

of the Contraindication
– the increased individual sensitivity to drug or its components
– an acute renal failure
– an acute liver failure
– pregnancy and the period of a lactation
– children’s and teenage age up to 18 years

With care: allergic diseases and reactions in the anamnesis, including hypersensitivity to sulfites.

Medicinal interactions
effect of benzodiazepine anxiolytics, antiepileptic Strengthens (carbamazepine), antidepressive, sleeping, protivoparkinsonichesky (levodopa) medicines that allows to lower their doses and to reduce side effects.
Increases anti-anginal activity of nitrodrugs.
Reduces toxic effects of ethanol.

Special instructions
It is necessary to appoint Neuroks with care to the patients having allergic reactions (acute anaphylaxis, a Quincke’s disease, etc.) in the anamnesis.
Neuroks it is usually well transferred, side reactions are rare, have short-term character and, in the majority, are connected with excessively high rate of administering.
The feature of influence of drug on ability to run motor transport and potentially dangerous mechanisms
during treatment needs to be careful at control of motor transport and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Symptoms: sleep disorders (insomnia, in certain cases – drowsiness), at intravenous administration – insignificant and short-term (up to 1.5-2 h) increase in arterial blood pressure.
Treatment: as a rule, it is not required – symptoms disappear independently within a day. In hard cases in insomnia – nitrazepam of 10 mg, oxazepam of 10 mg or diazepam of 5 mg. At excessive increase in arterial blood pressure – hypotensive medicines under control of arterial blood pressure.

A form of release and packing
On 2 ml or 5 ml of drug in ampoules of brown neutral glass type І with a color ring of a break or with a color point and a notch. One, two or three color rings and/or the two-dimensional barcode, and/or alphanumeric coding or without additional color rings, the two-dimensional barcode, alphanumeric coding in addition apply on ampoules.
On 5 ampoules in blister strip packaging from a film of polyvinylchloride and aluminum foil or a film polymeric, or without foil and a film.
On 1 blister strip packaging with ampoules on 5 ml or on 2 blister strip packagings with ampoules on 2 ml together with the instruction for medical use in the state and Russian languages in a pack from cardboard.

To Store storage conditions in the dry place protected from light, at a temperature not above 25 °C.
To store out of children’s reach!

3 years
not to use a period of storage after an expiration date.

Prescription status
According to the prescription

the Closed joint stock company Producer Farmfirma of Sotex, Russia
141345, the Moscow Region,
the Sergiyevo-Posadsky municipal district,
the Bereznyakovskoye rural settlement,
the settlement of Belikovo, 11
Ph./fax: (495) 956-29-30.

The owner of the registration certificate
Closed joint stock company Farmfirma of Sotex, Russia
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) of SP Tipkey 050004, RK, Almaty, Abylay Avenue of the khan 60, office 720. Ph.: +7 705 286 18 04
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