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Karipazim 350 PE powder for external use solution


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The instruction

for medical use

of medicine

The Trade name


the International unlicensed name

Is not present KARIPAZIM

the Dosage form

Powder 350 PE

Structure lyophilized for preparation of solution for external use

One bottle contains

active agent – the dried-up lacteal juice of a papaya 350 PE


White, with a yellowish shade, the lyophilized powder or porous weight with a slight specific smell.

Pharmacotherapeutic group

Drugs for treatment of wounds and ulcers. Fermental drugs.

The ATX D03B code

the Pharmacological

Pharmacokinetics At properties external use drug is not soaked up and has no system impact on an organism. At electrophoretic introduction Karipazim selectively collects in the field of the struck intervertebral disks. The enzymes which are Karipazim’s part collapse and biotransformirutsya completely in a liver.

The pharmacodynamics

Karipazim – the drug of plant origin received from latex of a melon tree (papaya)

Drug contains sulfhydryl proteolytic enzymes: papain, khimopapaina And yes B, peptidases of a papaya And yes B, papaya lysozyme and also number of amino acids, carbohydrates, salts Na, K, Mg, Ca. Drug is characterized by selective proteolytic activity hydrolyzes proteins of nekrotizirovanny fabrics to polypeptides, but is inactive in relation to healthy fabrics in connection with presence of inhibitors of proteases in them.
Karipazim treats proteolytic connections of plant origin. Properties of drug are caused by activity of three proteolytic enzymes: papain, a khimopapain and proteinase and also the mucolytic enzyme of lysozyme containing sulfhydryl groups in active centers.

At use by an electrophoresis method, karipazy getting into fabrics and creating depot in the field of the struck intervertebral disks, has local effect on connective tissue, including fabric of the disk and hernial protrusion. Drug causes hypersecretion of protein of collagen that leads to moderate scarring of a mesh and fibrous cover of a disk. Preservation of biosynthesis of hondroitinsulfat a part of cells of a disk raises a trophic role of a pulpozny kernel and restores turgor of a disk, doing it to more elastic.
Except proteolytic activity, the enzymes which are a part of drug have also significant antiedematous and anti-inflammatory effect. Improve blood circulation, stimulate phagocytosis, suppress activity of hyaluronidase and strengthen angenesis.

In burns of IIIA of degree promotes acceleration of rejection of strup and clarification of the granulating wounds from the remains it is purulent – necrotic fabrics.

– degree IIIA burns (for acceleration of rejection of strup and for clarification of the granulating wounds from it is purulent – necrotic masses)

– hernias of intervertebral disks of the cervical and lumbar

Route of administration level and a dose

not to apply indications subcutaneously, intramusculary and intravenously!

Karipazim’s use in degree IIIA burns

Karipazim is applied outwardly in the form of solutions with concentration of 17.5 PE/ml, 35 PE/ml or 70 PE/ml depending on scab thickness. Solutions prepare before the use for 0.5% solution of novocaine or 0.9% isotonic solution of sodium of chloride. For obtaining concentration of 17.5 PE/ml it is necessary to add 20 ml of solvent to Karipazim’s bottle, for obtaining concentration of 35 PE/ml it is necessary to add 10 ml of solvent to Karipazim’s bottle and for obtaining concentration of 70 PE/ml it is necessary to add 5 ml of solvent to Karipazim’s bottle. The napkin moistened with drug is imposed on a burn surface, closed a water-proof bandage.

At the same time process no more than 30% of the general body surface. The bandage is changed 1 time a day or 1 time in 2 days, removing the flaking necrotic fabrics.

Course of treatment from 4 to 12 days.

The method of electrophoretic introduction Karipazima

Karipazim is entered by an electrophoresis method only from a positive pole.

An electrophoresis Karipazima in a backbone.

Treatment course – 2-3 courses (1 course from 20 to 30 procedures).

Breaks in 1-2 days between procedures are allowed.

Repeated courses in 30-60 days.

1 or 0.5 bottles Karipazima part in 5-10 ml of normal saline solution just before the procedure. Add 1-2 drops of Dimexidum to solution. Solution is applied on filter paper which is placed on positive laying of an electrode and placed on area of pathology. The amount of laying is 10х15.15х20 cm. Apply 3-5 ml of 2.4% of solution of Aminophyllinum (Euphyllinum) on laying of a negative electrode.

Options of arrangement of laying:

longitudinal a) Karipazim on area of a neck (+)

Euphyllinum on area of a waist(s)

b) Karipazim on area of a neck (+)

Euphyllinum on area of a shoulder(s)

c) Karipazim on area of a neck (+)

Euphyllinum on both shoulders the doubled electrode (-)

d) Karipazim on area of a waist (+)

Euphyllinum on a point of an exit of a sciatic nerve (-) (the back

surface of a hip)

e) Karipazim on area of a waist (+)

Euphyllinum on area of hips (-) the doubled electrode

cross a) Karipazim on area of a waist (+)

Euphyllinum on area of a stomach (-)

Temperature of laying – it is strict 37-39 C – it is controlled by the water thermometer.

Current 10-15 ma (to increase gradually).

Time of exposure from 10 to 20 min. also increases gradually.

Non-compliance with these parameters leads to sharp decrease in efficiency of drug.

After the procedure to process leather on the injection site of medicine warm, soap water.

Side effects

Are possible

– allergic reaction in the form of an itching and temperature increase

of the Contraindication

– the increased individual sensitivity to drug

– acute inflammatory processes in fabrics

– a sekvestrirovaniye and foramenalny arrangement of hernia

– the considerable shift of vertebrae

– oncological diseases in a small pelvis

– acute viral diseases

– children’s and teenage age up to 18 years

– pregnancy and the period of a lactation

Relative contraindications for use Karipazima in neurologic practice are intolerable pains, gross and permanent violations of sensitivity, decrease in animal force or a plegiya in a zone of an innervation of the struck segment, disturbances of functions of pelvic bodies in the absence of effect of conservative therapy

Medicinal interactions

is not established clinically significant interactions Karipazima with other drugs.

Special instructions

Use for children

is not recommended for use for children and teenagers up to 18 years in view of lack of clinical data on safety and efficiency of medicine.

Pregnancy and the period of a lactation

Due to the lack of data on safety and efficiency of medicine use during pregnancy and in the period of a lactation is not recommended.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms.

Does not influence.


Cases of overdose are not described. Probability is minimum as drug is used only outwardly.

Forms of release and packing

On 350 PE drugs in the bottles of colourless glass with a capacity of 10 ml corked by traffic jams from rubber and which are pressed out by caps aluminum.

On 1 bottle together with the instruction for medical use in the state and Russian languages put in a pack from cardboard bandbox.

To Store storage conditions in the dry, protected from light place at

a temperature from 2 wasps up to 8 wasps.

To store out of children’s reach!

2 years

not to use a period of storage after the expiry date specified on packing.

Prescription status

According to the prescription

the Address Institute of Pharmacochemistry Producer Iovela Kutateladze: st. of the Item. Saradzhishvili No. 36, Tbilisi, 0159, Georgia.

The owner of the registration certificate

Institute of Pharmacochemistry of Iovel Kutateladze

the Address of the organization accepting in the territory of the Republic of Kazakhstan
claims from consumers on quality of products (goods)
050042, Almaty, mdt. Taugul 1, 91 A
ph.: 8 (727) 309 51 41, fax: 8 (727) 309 51 40,

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