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MEXIDOL® (Emoxipine) 125 mg, 50 coated tablets
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ARPEFLU (Umifenovir) 100 mg, 20/30 caps
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Description
The instruction for medical use of KANDIBIOTIK medicine the Trade name Kandibiotik Mezhdunarodnoye the unlicensed name Is not present the Dosage form of the Drop ear, 5 ml Structure 1 ml contains active agents: Clotrimazolum of 10 mg, chloramphenicol of 50 mg, beclomethasone Dipropionas of 0.25 mg, lidocaine hydrochloride of 20 mg, excipients: glycerin, propilengilikol. Description Transparent liquid of light yellow color. Pharmacotherapeutic group Drugs for treatment of diseases of sense bodys. Glucocorticosteroids in a combination with antimicrobial drugs. The ATH S02CA code the Pharmacological Pharmacokinetics Chloramphenicol properties well gets into liquids and fabrics both at local, and at system use. Beclomethasone Dipropionas is practically not soaked up at topical administration. Clotrimazolum at topical administration is soaked up minimum. Traces (less than 0.001 mkg/ml) were found in serum in 48 hours after drawing 0.5 ml of solution. It is removed generally with a stake and bile, only 0.05% – 0.5% of Clotrimazolum are removed with urine. Lidocaine can be soaked up in a serous layer at topical administration. Absorption of drug depends on concentration, a dose, the place of use and also duration of use (exposure) of drug. The pharmacodynamics Chloramphenicol – derivative an amfenikola, an antibiotic of a broad spectrum of activity, affects synthesis of bacterial protein. Has bacteriostatic action. It is active concerning gram-positive bacteria: Staphylococcus spp., Streptococcus spp., gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp., is active also concerning Spirochaetaceae. Chloramphenicol is active concerning the strains resistant to penicillin, streptomycin, streptocides, also anaerobic microflora. Beclomethasone Dipropionas – the halogenated glucocorticosteroid, possesses anti-inflammatory, antiallergic and antiexudative action. Clotrimazolum – derivative an imidazole, the antifungal activity is directed to a cellular membrane of fungi. Breaks synthesis of ergosterol of a cellular membrane of fungi, than damages a cell wall. Ergosterol – the main component of a cytoplasmic membrane of fungi Clotrimazolum is built in synthesis of ergosterol and its effect depends on concentration. Lidocaine – local anesthetic, breaks conductivity of nervous impulses in the sensitive terminations of nerve fibrils in the site of application. Reversible effect. Local anesthesia is often applied to anesthesia with preservation of an innervation. Lidocaine is often applied to surface anesthesia, the effect develops rather quickly and proceeds within 6 hours. Indications Allergic and inflammatory diseases of an ear: – acute diffusion external otitis – acute otitis of a middle ear – chronic otitis in an aggravation stage – a state after surgical intervention on an ear the Route of administration and doses Locally. For use of drug it is necessary to incline the head, to dig necessary quantity of drops in an ear and to hold the head inclined some time to provide penetration of drug into acoustical pass. To adults and children 12 years are more senior – on 3-4 drops of drug to dig in in acoustical pass 3-4 times a day. The course of treatment is established individually, depending on severity and a course of the disease and averages 5-7 days. To children aged from 2 up to 12 years – on 2 drops 4 times a day. The course of treatment makes 5 days. Side effects – burning, an itching in the site of application of drug – allergic reaction of the Contraindication – hypersensitivity to drug components – children’s age up to 2 years – disturbance of integrity of a tympanic membrane Medicinal interactions Because of low transdermal absorption of active components of drug, medicinal interactions are considered as improbable. Special instructions Only for topical administration. To avoid hit in eyes. At hit in eyes carefully to wash them with water. If are observed deterioration or not improvements of a state after regular use, see a doctor. Pregnancy and the period of a lactation Prescribing of drug during pregnancy and a lactation is possible if the expected advantage for mother exceeds potential risk for a fruit and the child. Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Use of drug does not affect ability to run motor transport or potentially dangerous mechanisms. Overdose Symptoms: the overdose is improbable, but in case of accidental overdose strengthening of side effects is possible. Treatment: to wash out an affected area, symptomatic treatment. A form of release and packing On 5 ml of drug in a bottle from dark glass with the screwing-up cover. The bottle together with the pipette and the instruction for medical use in the state and Russian languages is put in a box of cardboard. To Store storage conditions in the dry, protected from light place at a temperature not above 25 °C. Not to freeze. To store out of children’s reach! 2 years not to apply a period of storage after an expiration date. Prescription status According to the prescription of Proizvoditel Glenmark Pharmasyyutikalz Ltd, the RAFT No. E 37.39, MIDS of Area, Saptur, Nasik – 422007, Maharashtra, India. The name and the country of the owner of the registration certificate of Glenmark Pharmasyyutikalz Ltd, India the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) of Predstavitelstvo Glenmark Pharmasyyutikalz LTD in RK, 050005, Almaty, Al-Farabi Avenue, 7, business center of Nurla Tau, block 4 A, office 7. ph. + 7 (727) 311 04 41.
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