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Glucophage® XR (Metformin) 500 mg (30 coated tablets)




One tablet contains the active substance – metformin hydrochloride 500 mg

Indications for the use of Glucophage XR

Type 2 diabetes mellitus (non-insulin dependent) in adults (especially in overweight patients) with ineffective diet therapy and exercise, as monotherapy or in combination with other oral hypoglycemic agents or in combination with insulin.

How to use Glucophage XR? Dosage

Adult patients with normal renal function (GFR ≥90 ml / min).

Monotherapy or combination therapy in combination with other oral hypoglycemic agents.

The recommended starting dose is 1 tablet per day.

After 10-15 days of treatment, the dose must be adjusted depending on the results of blood glucose measurements. A slow increase in the dose helps to reduce the severity of side effects from the digestive tract. The maximum recommended dose is 4 tablets per day.

The dose should be taken 1 time per day with meals in the evening, increasing by 500 mg every 10-15 days to 2000 mg. If it is impossible to achieve the required glycemic level when using the drug Glucophage XR at a dose of 2000 mg, which the patient takes once a day, you should use Glucophage XR at a dose of 1000 mg 2 times a day during meals.

If the required glycemic level is not reached, you can take Glucophage, film-coated tablets, at the maximum recommended dose of 3000 mg per day.

For patients treated with metformin hydrochloride, the initial dose of Glucophage XR, sustained-release tablets, should be equivalent to the dose of immediate-release tablets. Patients receiving metformin therapy at a dose of> 2000 mg / day are not recommended to switch to therapy with Glucophage XR.

If you switch to Glucophage XR, sustained-release tablets, 500 mg, you must stop taking another antidiabetic drug for oral use.


Hypersensitivity to metformin hydrochloride or any excipient, diabetic ketoacidosis, diabetic pre-coma, coma, renal failure or impaired renal function (creatinine clearance less than 60 ml / min), dehydration, severe infection, hypoglycemic shock, which can lead to impaired renal function, clinically pronounced manifestations of acute and chronic diseases that can lead to the development of tissue hypoxia (heart or respiratory failure, acute myocardial infarction and shock, liver failure, acute alcohol intoxication, alcoholism

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