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Ginenorm 100 ml of 0.1% solution vaginal 5’s


Brands:: MITIM (Italy)


The instruction for medical use of Ginenorm Torgovoye medicine a name Ginenorm Mezhdunarodnoye the unlicensed name Ibuprofen Dosage Form Solution of Vaginal 0.1%, 100 ml Structure of 100 ml of drug contains active agent – an ibuprofen of isobutylammonium of 100.0 mg (it is equivalent to an ibuprofen of 69.8 mg), excipients: metiletilpropilbutil-2-phenoxyethanol-p-hydroxybenzoate (undebenzofen), polysorbate 20, propylene glycol, essence flower, water the Pharmacotherapeutic group cleaned the Description Transparent colourless solution Anti-inflammatory drugs for intravaginalny use. The code of automatic telephone exchange G02CC01 the Pharmacological Pharmacokinetics At properties intravaginalny use absorption insignificant, has no systemic action. The research of bioavailability established that at drug Ginenorm use ibuprofen level in blood plasma low, on a limit of analytical sensitivity. A pharmacodynamics the Mechanism of action of Ginenorm is connected with oppression of activity of cyclooxygenase (COG) – the main enzyme of metabolism of arachidonic acid, being the predecessor of prostaglandins which play a major role in pathogenesis of inflammation, pain and fever. The anti-inflammatory effect is connected with reduction of permeability of vessels, microcirculation improvement, decrease in release from cells of mediators of inflammation (prostaglandins, kinina, leukotrienes) and suppression of power supply of inflammatory process. Analgeziruyushchy action is caused as peripheral (it is mediated, through suppression of synthesis of prostaglandins), and the central mechanism (caused by inhibition of synthesis of prostaglandins in the central and peripheral nervous system). Suppresses aggregation of thrombocytes. Febrifugal action is connected with reduction of excitability of the heatregulating centers of a diencephalon. The ibuprofen reversibly inhibits the aggregation of thrombocytes caused by adenosinediphosphate and collagen. Indications – a vulvovaginitis and tservikovaginita of all types – to – and postoperative treatment in gynecologic surgery the Route of administration and doses 1 or 2 vaginal syringings a day, depending on the recommendations of the doctor. Solution can be used room temperature or is slightly higher, by warming of a bottle under a hot water jet. 1. Press the acting part of a cover aside to break. 2. Take a sterile cannula from protective packing, insert into a bottle and be convinced of its stability. 3. Carefully enter a cannula into a vagina and squeeze a bottle, will not be absolutely empty yet. 4. Detain liquid in a vagina several minutes that solution could have therapeutic effect. Duration of treatment is 3-7 days. Side effects Very seldom – skin reactions, including exfoliative dermatitis, Stephens’s syndrome – Johnson and a toxic epidermal necrolysis (Lyell’s disease) of the Contraindication – hypersensitivity to any of components of drug or the substances similar in the chemical composition – pregnancy and the period of a lactation – girls up to 16 years Medicinal interactions are not established the Special instructions Emergence of Any Undesirable Effect, not included in the instruction, has to be brought to the doctor or the druggist. The Ginenorm drug treatment has to be interrupted at appearance of rash on skin, a mucous membrane or at other damages or signs of hypersensitivity. Prolonged use of the drug Ginenorm can lead to irritation of a mucous membrane. In this case it is necessary to interrupt treatment and to begin the corresponding treatment. Features of influence of medicine on ability to run the vehicle and potentially dangerous mechanisms the Overdose Due to low extent of absorption in a system blood stream does not influence the overdose is improbable. A form of release and packing of 0.1% solution of vaginal, 100 ml On 100 ml of drug in a bottle from polyethylene of low density with a cover from polyethylene of high and low density. On each bottle paste the sticky label. On 5 bottles place in cardboard packing together with the instruction for medical use in the state and Russian languages. Sterile cannulas are packed separately into blister strip packagings from a film of polyvinylchloride and aluminum foil. To Store storage conditions at a temperature not over 25 of 0C. To store out of children’s reach! A period of storage 3 years Prescription status According to the prescription the Producer Mitim s.r.l., Italy Owner of the registration certificate Aesculapius Farmaceutici S.r.l., Via Cozzaglio, 24-25125 Brescia, Italy the Address of the organization accepting claims from consumers on quality of a product in the territory of the Republic of Kazakhstan AVITA (AVITA) LLP, Almaty, Tchaikovsky Street, 15-

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