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Fenkarol 25 mg (20 tablets)




The instruction for use
of medicine for experts
F E N K A R About ï® 25 mg
the Trade name
of Фенкарол® 25 mg

the International unlicensed

name Hifenadin Lekarstvennaya
the Tablet form on 25 mg
One tablet contains
active agent – Phencarolum (a hifenadin a hydrochloride) 25 mg,
excipients: sugar, potato starch, calcium stearate.
The description
of the Tablet of white or almost white color
Pharmacotherapeutic group
Antihistaminic drugs for system use.
The code of automatic telephone exchange R06A
the Pharmacological

Pharmacokinetics of 45% of Phencarolum properties is quickly soaked up from digestive tract and in 30 minutes it is found in body tissues. The maximum concentration of active ingredient in blood plasma is reached in an hour. The highest concentration of active ingredient is observed in a liver, lungs and kidneys, the lowest – in brain tissues. Hifenadin has low lipophilicity and his content in brain fabrics low (less than 0.05%) that explains lack of the oppressing influence on the central nervous system, but at individual hypersensitivity the weak sedation is possible.
Hifenadin is metabolized in a liver. Metabolites and not changed share of drug are removed generally with urine, bile and through lungs. Through intestines not absorbed part of drug is removed. The main part of drug and its metabolites (about 44%) are removed with urine within 48 hours and another 1% within the next 48 hours.
The pharmacodynamics
Phencarolum – antihistaminic means (derivative a hinuklidilkarbinola), reduces impact of a histamine on bodies and their systems.
Phencarolum blocks histamine H1 receptors in peripheral fabrics and also activates enzyme diaminoxidase (histaminase), thus, reducing the maintenance of a histamine in fabrics. The efficiency of Phencarolum for patients whose treatment by other antihistaminic means inefficiently is explained by it. Phencarolum has low lipophilicity therefore badly gets through a blood-brain barrier, poorly influences processes of deamination of serotonin in tissues of a brain and on activity of enzymes of monoamine oxidase.
Phencarolum reduces toxic action of a histamine, eliminates or weakens bronkhokonstriktorny action and spazmiruyushchy influence on smooth muscles of intestines, weakens hypotensive action of a histamine and its influence on permeability of capillaries. Phencarolum possesses moderate antiserotoninovy and weak cholinolytic action, does not possess adrenolytic action.
Drug renders expressed antipruritic, desensibilizing and also moderate diuretic action.

– pollinoses
– food and medicinal allergy, other allergic diseases
– acute and chronic urticaria
– (angioneurotic) Quincke
– hay fever
– allergic rhinitis
– a dermatosis (eczema, neurodermatitis, a skin itching)
– non-infectious and allergic reactions with a bronkhospastichesky component swelled.

The route of administration and doses
accept Phencarolum inside right after food.
A dose for adults – on 25-50 mg 3-4 times a day. The maximum daily dose makes 200 mg. Duration of a course of treatment is 10-20 days. If necessary the course is repeated.
To children 12 years are more senior – on 25 mg 2-3 times a day. Duration of a course of treatment is 10-15 days. If necessary the course is repeated.

Side effects
– moderate dryness of mucous membranes of an oral cavity
– the dispeptic phenomena
usually undergo Side effects at reduction of a dose or drug withdrawal.
Probability of emergence of side effects increases in digestive tract diseases.

– hypersensitivity to Phencarolum or to auxiliary components of drug.

Medicinal interactions
Phencarolum does not strengthen the oppressing effect of sleeping medicines on the central nervous system. Phencarolum has weak M-holinoblokiruyushchimi properties, but at decrease in motility of digestive tract the absorption of slowly absorbed medicines can amplify (for example, anticoagulants of indirect action – coumarins).

The special
instructions Observe care in a serious illness of a cardiovascular system, digestive tract or liver.
Use in pediatrics
In children’s practice is applied by the tablets Phencarolum of 10 Mg.
Pregnancy and the period of a lactation
is not recommended to be accepted in the I trimester of pregnancy and during feeding by a breast.
Influence on ability to run the vehicle
to Adults whose work demands fast physical or mental reaction (drivers of transport, etc.) should be established previously (by short-term appointment) whether drug has sedative effect. These persons need to be careful.

Symptoms: dryness of mucous membranes, a headache, vomiting, pains in epigastriums and other dispeptic phenomena.
Treatment: carry out symptomatic therapy. There is no special antidote.

A form of release and packing
of the Tablet on 25 mg No. 10 in the blister from a film of the polyvinylchloride and aluminum foil varnished.
20 tablets in a pack from cardboard together with the instruction for use.

To Store storage conditions in the dry, protected from light place at a temperature from +15 °C to +25 °C.
To store out of children’s reach!

A period of storage
4 years
it is impossible to use Drug after expiry date.

Prescription status
According to the prescription

JSC Olaynpharm producer.
Address: Rupnitsu St. 5, Olaine, LV – 2114, Latvia.

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