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The instruction for medical use of Adsorbiks® medicine the Extra Trade name of Adsorbiks® the Extra International unlicensed name Is not present the Dosage form of the Capsule of 200 mg Structure One capsule contains active agent – the micronized activated carbon of 200 mg, excipients: gelatin, titan dioxide (E 171), ferrous oxide black (E 172). Description Solid gelatin capsules of black color of 1 in size, flavourless and taste. Contents of capsules – powder of black or darkly gray color Pharmacotherapeutic group Intestinal adsorbents. Coal drugs. The ATX A07BA01 code the Pharmacological Pharmacokinetics Micronized properties the activated carbon of plant origin with strong porous globular structure produced on special technology which increases porosity at the expense of what its high adsorptive ability is provided. Possesses mainly micro and mesoporosity that allows to adsorb effectively substances of molecular mass of a wide range. Possesses the big adsorbing surface: 2000 sq.m on 1 g of substance and ability to actively absorb from digestive tract before absorption to the blood channel gases, alkaloids, gliklazida, barbiturates and other hypnotic drugs and drugs, salts of heavy metals, endo- and exotoxins of bacterial, plant, animal origin and also derivatives of phenol, salicylic acid, streptocides and other chemical compounds. In process of passing on intestines the components connected by it are not exposed to a desorption and do not change rn Wednesdays. Activated carbon is not soaked up from digestive tract therefore there is both no distribution period, and any metabolism. It is removed in an invariable look. The pharmacodynamics of Adsorbiks® Extra has the adsorbing, disintoxication and antidiarrheal effect. Actively absorbing the gas which is formed at digestion disturbance, interferes with restretching of walls of intestines, thereby, warning and stopping pain. In infectious diseases, such as acute dysentery, salmonellosis, viral hepatitis, typhoid, leptospirosis, hemorrhagic fevers, ornithosis, Adsorbiks® Extra, absorbs pathogenic strains and their toxins. Connecting toxins of microbic and endogenous origin, drug reduces load of bodies of a detoxication and excretion, eliminates diarrhea in acute intestinal diseases (rotavirus gastroenteritis, cholera, poisoning with staphylococcal enterotoxin). At allergic states the therapeutic effect of drug is caused by its ability to connect food-borne allergens, a histamine, serotonin and also the circulating cell-bound immune complexes and bacterial antigens that brings to strengthening of cell-mediated and antibody-mediated immunity, increase in quantity of T lymphocytes, decrease in eosinophils and reduction of an itching, hypostasis, urticaria. Chronic diseases of bodies of digestive tract are followed by disbolism and accumulation of intermediate toxic metabolites with forming of a syndrome of endogenous intoxication. At the same time considerable strengthening of peroxide oxidation of lipids promotes damage of cellular membranes and accumulation of free radicals, hydroperoxides, aldehydes and ketones. Адсорбикс® Extra leads to normalization of a microbiocenosis of intestines to ibystry improvement of health. In diseases of a liver, such as cirrhosis, viral and chronic hepatitis, administration of drug accelerates normalization of serumal concentration of bilirubin, activity of transaminases, indicators of reaction of a blasttranformation of lymphocytes, stimulated antigens of tissue of liver and spleen, shortens circulation time in blood of specific humoral antibodys (HBs) and antigens of a virus of hepatitis In (HBsAg), reduces expressiveness of the general symptoms of a disease. In acute pancreatitis of Adsorbiks® Extra promotes fast restoration of a vermicular movement of intestines, decrease in intoxication, normalization of biochemical indicators of an endotoxemia, easing of dispepsichesky disorders and a pain syndrome. Адсорбикс® Extra reduces the level of toxins and eliminates intoxication symptoms at lead, alcoholic and medicinal ekzotoksikoza, burn and radiation sickness, chronic intoxications on harmful production. In chronic kidney disease, as a result of an enterosorbtion against the background of administration of drug, concentration of urea, creatinine and molecules of average weight in blood decreases that in turn leads to reduction of symptoms of uraemic intoxication. Адсорбикс® Extra does not contain sorbitol and soda in quality of excipients that is the key to its high neutralizing ability. Existence of an enterosoluble gelatin capsule ensures full safety of enterosorbiruyushchy activity as drug does not contact to a mucous membrane of a stomach and proteinaceous components of gastric juice, and works directly in a small intestine where the substances participating in enterogepatichesky circulation are occluded. Indications as a part of combination therapy in the following diseases: – food toxicoinfection – dysentery, salmonellosis – a coloenteritis – diarrhea, a meteorism, processes of rotting, fermentation, hypersecretion of slime, hydrochloric acid – poisoning with chemical compounds and medicines (including organophosphorous and organochlorine compounds, psychotropic drugs) – poisoning with alkaloids, salts of heavy metals – a burn disease in a stage of a toxaemia and a septicotoxemia – chronic kidney disease – chronic hepatitis, an acute viral hepatitis, cirrhosis – allergic diathesis, atopic dermatitis, an allergic gastroenteritis, toksikodermiya – an abstinence alcoholic syndrome – preparation for X-ray inspections (for gas generation reduction) the Route of administration and doses Appoint inside. Capsules should be accepted with water. The adult on 1-3 capsules, 3-4 times a day in 1-2 hours prior to or after meal or medicines. In acute poisonings and acute pancreatitis about 10 capsules in day for 2-3 days after independent swallowing are recommended to accept. In moderately severe acute pancreatitis Extra it is reasonable to carry out use of Adsorbiks® in combination with extracorporal hemosorption. The maximum single dose-4 capsules, the maximum daily dose – the 12th capsules. To children 6 years on 1-3 capsules 2 times a day are more senior. In acute poisonings and acute pancreatitis on 1-3 capsules 2-3 times a day. Maximum single dose 3 capsules, maximum daily dose of-9 capsules. Treatment duration in acute poisonings is 3-5 days. In chronic intoxications from 10 to 14 days. In chronic kidney disease the indication to purpose of Adsorbiks® Extra is the creatinemia of 0.4 mmol/l and above. Side effects – a constipation – dyspepsia, nausea, vomiting – a diarrhea – decrease in absorption from a GIT of fats, proteins, vitamins, hormones – hemorrhages, a hypoglycemia, a hypocalcemia, a hypothermia, hypotension – candidiasis of a mucous membrane of an oral cavity – Contraindication dysbacteriosis – hypersensitivity to activated carbon or any component of drug – gastrointestinal impassability and suspicion on intestinal impassability – sharp abdominal pain, nonspecific ulcer colitis, bleedings from a GIT – children’s age up to 6 years Medicinal interactions Reception of Adsorbiks® Extra reduces efficiency of the oral medicines intended for increase in arterial blood pressure and antirheumatic drugs. The concomitant use of activated carbon and furosemide or oral contraceptives, can cause decrease in efficiency of the last. In such cases the use of additional methods of contraception is necessary. Special instructions At administration of drug there is a coloring of stool in dark color. In case diarrhea remains after three days of treatment, additional clinical and biochemical trials, for identification of a cause of illness have to be conducted. It is not recommended to apply activated ugl to patients who receive antiperistaltic treatment, because of risk of development of intestinal impassability which can lead to perforation. It is necessary to accept activated carbon not less, than in 1-2 hours prior to or after intake of other medicines. Pregnancy and the period of a lactation Use of Adsorbiks® Extra is not contraindicated at pregnancy and feeding by a breast. The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms does not affect ability to run the vehicle or potentially dangerous mechanisms. Overdose Symptoms: nausea, vomiting and constipation, intestinal impassability. Treatment: to cancel drug, to appoint laxatives. A form of release and packing On 15 capsules in blister strip packaging from a film of PVH/PVDH and aluminum foil. On 1 or 2 planimetric packs together with the instruction for use in the state and Russian languages place in a cardboard pack. To Store storage conditions in the dry, protected from light place, at a temperature from 15o to 25 wasps. To store out of children’s reach! A period of storage of 5 years not to use drug after the expiration date specified on packing. Prescription status Without prescription the Producer of Kabot Norit the Netherlands Bee. Vee., the Netherlands Mr.Ovingkanaal O.Z.3, 7891 EV Klazienaveen, the Netherlands the Owner of the registration certificate of A-MARK S.A., Switzerland En reutet B, 1868 Collombey, Switzerland the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products Representative office of Seltfar SA. Almaty, Al-Farabi Ave. 5, Nurla Tau 1A, office 301, ph. / fax +7 (727) 311 16 28
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