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Day and Night (10 coated tablets)


Brands:: MUP (Egypt)


The instruction for use

of medicine for experts

Day and night

the Trade name

Day and night

the International unlicensed name

Is not present

the Dosage form

of 5 tablets coated + 5 tablets with the prolonged release


Each white oval (day) tablet with the prolonged release contains

active agent: paracetamol of 600 mg

of Phenylephrinum of a hydrochloride of 20 mg

excipients: cellulose of microcrystalline 140 mg

of a hydroksipropilmetiltsellyuloza of 13 mg

of povidone of 40 mg

of the RS eudragit of 16 mg

of silicone of dioxide of colloidal 2 mg

of magnesium stearate of 6 mg.

Each yellow round (night) coated tablet contains active agent: paracetamol of 500 mg

of a difengidramin hydrochloride of 25 mg

excipients: cellulose of microcrystalline 68.35 mg

of povidone of 40 mg

of magnesium of stearate of 6 mg

of a kroskarmelloza of 25 mg

of a hydroksipropilmetiltsellyuloz of 8.82 mg

of the titan of dioxide of 5.88 mg

of talc of 1.961 mg

of polyethyleneglycol of 2.163 mg

of a kinolin of yellow 2.53 mg

of polysorbate of 0.196 mg

of an emulsion of antifoam 0.1 mg

the Description

the White oval tablet

the Yellow round tablet, coated

Pharmacotherapeutic group

Other analgetics and febrifuges

the Code of automatic telephone exchange N02BG

Pharmacological action


Paracetamol is quickly and completely soaked up in digestive tract with achievement of peak concentration in plasma in 0.5-2 hours. Distribution: 25% of paracetamol contact proteins.

Metabolism: about 90-95% are metabolized in a liver.

Removal: paracetamol is removed with urine. Average elimination half-life fluctuates from 1 to 4 hours.

Phenylephrinum is quickly absorbed from a GIT (see clearance rate). Use of modern technologies provides gradual release of Phenylephrinum and the prolonged action of day tablets. Metabolism of Phenylephrinum is carried out in a liver and in intestines with monoamine oxidase enzyme participation.

A pharmacodynamics

the Mechanism and a site of action are not clear and can be connected with suppression of synthesis of a prostagladin in central nervous system.

Antipyretic action: it is considered to be that antipyretic effect of paracetamol is caused by its direct impact on the hypothalamic centers of attemperation of a body owing to what there is calorification to the environment as result of vasodilatation and the strengthened sweating.

The anesthetizing action: can speak increase in a threshold of painful sensitivity.

Difengidramin at intake is quickly and well soaked up, the maximum concentration in plasma is reached in 14 h. Linking with proteins of plasma – 9899%. The most part is metabolized in a liver, smaller – is removed in not changed view with urine for 24 Parts T1/2 makes 1-4 h. It is well distributed in an organism.

It is excreted with milk of mother and can cause sedation in children

of chest age. The maximum activity develops in 1 h, action duration – from 4 to 6 h.

The pharmacodynamics

Drug possesses the febrifugal, anti-inflammatory, anesthetizing action thanks to nonsteroid anti-inflammatory active component to the paracetamol which is a part of both a day, and night tablet.

The paracetamol which is a part of drug Day and night inhibits prostaglandin synthesis. The day tablet, besides paracetamol, contains Phenylephrinum which is alpha adrenomimetikom and possesses vasoconstrictive action thanks to which hypostases of mucous membranes of upper airways decrease. The night tablet, besides paracetamol, contains difengidramin which is a blocker of H1-histamine receptors, has antiallergic activity, causes sedative and somnolent effects.


– catarrhal diseases

– flu

– spring Qatar, a rhinorrhea, the increased body temperature, sinusitis

– allergic rhinitises

the Route of administration and doses

One white day tablet after a breakfast and one yellow tablet for the night. Treatment duration – no more than 5 days

Side reactions

– a headache

– irritability

– increase in arterial blood pressure

– seldom or never – a skin itching and heartbeat

– at prolonged use in high doses perhaps hepatotoxic action

of the Contraindication

– pregnancy and feeding by a breast

– competitive treatment by monoamine oxidase inhibitors

– arterial hypertension

– heavy atherosclerosis

– hypersensitivity to drug ingredients

– children’s age up to 12 years

Medicinal interaction

Difengidramin: MAO inhibitors enhance cholinolytic effects of a difengidramin. At combined use with psychostimulants the antagonistic interaction is noted.

Paracetamol: At co-administration of barbiturates, anticonvulsants, rifampicin, alcohol the risk of hepatotoxic action considerably increases.

Phenylephrinum: At simultaneous use with MAO inhibitors the potentiation of effects of Phenylephrinum is observed. Fenotiazina, alpha adrenoblockers (phentolamine), furosemide and other diuretics reduce vasopressor effect of Phenylephrinum. Oxytocin, ergot alkaloids, tricyclic antidepressants, furasolidone, Procarbazinum, selegilin, sympathomimetics enhance pressor effect, and the last – and an aritmogennost.

The special

instructions Apply with care at persons with a hyper thyroidism, hypertensia, coronary insufficiency, diabetes (melitus), closed-angle glaucoma, a prostatauxe, the stenosing ulcer of stomach and duodenum, a bladder neck stenosis.

During treatment it is necessary to avoid consumption of alcoholic beverages.

The effects affecting ability to run the vehicle or potentially dangerous

Difengidramin mechanisms being a part of a night tablet causes the general weakness, fatigue, decrease in attention, dizziness, drowsiness, a lack of coordination of movements. Drug should not be used in operating time to drivers of vehicles and people whose profession is connected with the increased concentration of attention, demands fast mental and motor reaction, at night.

Drug has to be used only in the specified doses, no more specified period of time and is strict according to indications.

It is strongly recommended to observe the specified order of reception of tablets (yellow – before going to bed and white – in the morning after a breakfast) since at reception of a yellow night tablet the dizziness and drowsiness are possible in the afternoon.


of Cases of overdose by drug Day and night it was not registered. At approach of medicinal poisoning the development of the symptomatology characteristic of each of active components is possible.

Difengidramin provokes symptoms: dryness in a mouth, the complicated breath, a resistant mydriasis, face reddening, oppression or excitement (is more often at children) central nervous system, confusion of consciousness, children have a development of spasms.

Paracetamol: reception of big doses (more than 1015) of paracetamol can lead ment of a liver failure. Classical defeat develops in three stages. In several hours, acute gastrointestinal symptoms after taking the medicine appear. In 2448 hours these symptoms abate, and the second hidden stage of defeat begins , and in several days the hepatic jaundice often accompanied with a renal failure and toxic damage of other bodies develops.

Phenylephrinum causes hypertensia, tachycardia, with the subsequent bradycardia, spasms, psychosis, a hyperthermia.

Treatment: stimulation of vomiting, gastric lavage, prescribing of activated carbon, symptomatic and maintenance therapy against the background of careful control of breath and the ABP level.

Special antidote in poisonings with paracetamol is N-Acetylcysteinum which is applied orally in an initial dose of 140 mg/kg of body weight. Then drug is used each 4 hours in a dose of 70 mg/kg of body weight. The general duration of treatment usually equals to 72 hours.

Form of release and packing

Primary packing: the blister containing 5 white oval tablets and 5 yellow round tablets

Secondary packing: the cardboard box

to Store Storage conditions at a temperature not over +30 With

to Store out of children’s reach!

A period of storage

4 years

After the storage expiration not to use drug!

Prescription status

According to the prescription

The producer: Medikal Union Pharmasyyutikals, Egypt.

36, Mohamed Hassan El Gamal St., Nasr of City, Cairo 11768, Egypt ON Boxing 7010

Fax / phone number: (3272) 62 42 49, (202) 271 94 60. Fax: (202) 270-93-15. E-mail:,


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