1 ampoule contains
- active substances : disodium adenosine triphosphate trihydrate 10 mg, cocarboxylase 50 mg, cyanocobalamin 0.5 mg, nicotinamide 20 mg,
- excipients : glycine, methyl parahydroxybenzoate, propyl parahydroxybenzoate.
1 solvent ampoule contains: lidocaine hydrochloride 10 mg, water for injection up to 2 ml.
The therapeutic effect of the drug is the cumulative effect of its components. Therefore, pharmacokinetic studies are not possible.
The drug is a complex of metabolic substances and vitamins.
Disodium adenosine triphosphate trihydrate is a derivative of adenosine, stimulates metabolic processes. It has hypotensive and antiarrhythmic action. It has a vasodilating effect, including on the coronary arteries.
Cocarboxylase is a coenzyme formed in the body from thiamine (vitamin B1) supplied from outside. It plays an important role in carbohydrate metabolism, is part of the carboxylase enzyme, which catalyzes the carboxylation and decarboxylation of a-keto acids. Indirectly promotes the synthesis of nucleic acids, proteins and lipids. Reduces the level of lactic and pyruvic acids in the body, promotes the absorption of glucose. Improves the trophism of the nervous tissue.
Cyanocobalamin (vitamin B12) in the body turns into an active form of adenosylcobalamin or cobamide, which has a high biological activity. Increases protein synthesis in the body and promotes its accumulation. Activates the metabolism of carbohydrates and lipids. Lowers blood cholesterol levels, prevents fatty infiltration of the liver. Necessary for the normal functioning of hematopoietic organs, promotes the accumulation of compounds containing sulfhydryl groups in erythrocytes, increasing their resistance to hemolysis. Increases the ability of tissues to regenerate. Has a beneficial effect on the function of the liver and nervous system
Nicotinamide – one of the forms of vitamin PP, is involved in redox processes in the cell, improves carbohydrate and nitrogen metabolism, normalizes lipid metabolism, causes a decrease in the level of atherogenic lipoproteins in the blood.
Indications for use
– neuritis, neuropathy (in diabetes mellitus, pernicious anemia, etc.)
– neuralgia of various origins
– myalgia, sciatica
– lumbago, sciatica
– bursitis, tendonitis
– ischemic heart disease, myocarditis, myocardiopathy
Dosage and administration
Cocarnit is administered intramuscularly, 1-2 ampoules of the drug once a day.
The duration of treatment and repeated courses depend on the nature and severity of the disease and is determined by the attending physician
– Nausea, temporary mild diarrhea, increased diuresis
– headache, dizziness, sudden sweating, feeling of weakness, nervous excitement
– pulmonary edema, congestive heart failure at the beginning of treatment, peripheral vascular thrombosis
– tachycardia, pain in the heart
– allergic reactions (urticaria, angioedema, anaphylactic shock)
– hyperemia, itching, swelling at the injection site
– true polycythemia
– itching, transient exanthema.
With the development of severe side effects, the drug is canceled.
– hypersensitivity to any component of the drug
– acute period of myocardial infarction
– hypercoagulability (including acute thrombosis), erythremia, erythrocytosis, severe forms of arterial hypertension, arterial hypotension, inflammatory lung diseases, severe heart failure, psoriasis, severe conduction disturbances, acute heart failure.
Cocarboxylase enhances the cardiotonic effect of cardiac glycosides.
It should also be taken into account that vitamin B12 can enhance allergic reactions caused by vitamin B1.
With the simultaneous use of nicotinamide with antiepileptic drugs, especially with such as carbamazepine, diazepam, sodium valproate, their anticonvulsant effect may be potentiated.
Before the introduction of the drug Cocarnit in patients with suspected hypersensitivity to the components of the drug, an intradermal test is recommended.
When treating with cyanocobalamin, it is necessary to systematically conduct a blood test. With a tendency to develop erythro – and leukocytosis, the dose is reduced or the drug is temporarily stopped. In the process of treatment, it is necessary to control blood clotting and be careful in relation to persons with a tendency to thrombosis. You can not enter vitamin B12 in acute thromboembolic diseases.
Patients with angina, vitamin B12 should be prescribed with caution and in smaller doses (up to 0.1 mg per injection).
Cocarnit should be used with caution in patients with a history of peptic ulcer, gastritis, gout,
bleeding, lesions of the liver and biliary tract. With prolonged use of the drug, it is necessary to control the level of transaminases, alkaline phosphatase, GGTP, bilirubin, uric acid in the blood serum.
The color of the prepared solution should be red.
Do not use the solution if the color has changed.
The solution must be used immediately after its preparation!
Application in pediatrics
The safety and efficacy of the drug in children have not been studied.
Pregnancy and lactation
During pregnancy, Cocarnit should only be used if the expected benefit to the mother outweighs the potential risk to the fetus.
It is recommended to stop breastfeeding for the duration of treatment with the drug.
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Patients who experience dizziness during the use of Cocarnit, headache should not engage in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Symptoms: increased side effects of the drug.
Treatment: symptomatic and drug withdrawal.
Store in a place protected from light at a temperature not exceeding 25°C.
Keep out of the reach of children!
Shelf life 3 years
Do not use after the expiration date.