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Clotrimazole 100 mg vaginal suppositories 6’s




The instruction for medical use


the Trade name

the International unlicensed

name Clotrimazolum Dosage Form
Suppositories vaginal, 100 mg

One suppository contains
active agent – Clotrimazolum of 100 mg,
excipients: semi-synthetic glycerides suppotsir –
enough for receiving a suppository weighing 2 g.

The description
of White color or white with a yellowish shade suppositories of a tsilindrokonichesky form. On a cut the existence of an air and porous core and funneled deepening

Pharmacotherapeutic group
of Antiseptics and antimicrobial drugs for treatment of gynecologic diseases is allowed. Imidazole derivatives.
The code of automatic telephone exchange G01AF02

the Pharmacological

Pharmacokinetics Clotrimazolum properties in small degree is absorbed from mucous membranes and has practically no systemic action. At intravaginalny introduction 3-10% of the entered dose are absorbed. High concentrations in a vaginal secret and low concentration in blood remain during 48-72 h. In a liver it biotransformirutsya quickly to inactive metabolites and
the Pharmacodynamics
Clotrimazolum – the antifungal broad-spectrum agent derivative of an imidazole is removed with excrements. Has antifungal, antibacterial and trikhomonatsidny effect.
The mechanism of action is connected with disturbance of synthesis of the ergosterol which is a component of a cellular membrane of mushrooms, change of permeability of a membrane of a mushroom and lysis of a cell.
It is active concerning pathogenic dermatophytes (Epidermophyton floccosum, Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, mold and yeast-like mushrooms (Candida spp., Torulopsis glabrata, the sorts Rhodotorula, Pityrosporum orbiculare.

– the genital infections caused by dermatophytes, mold and yeast-like mushrooms and/or Trichomonas vaginalis
– the vaginal bacterial superinfections caused by microorganisms, sensitive to Clotrimazolum,
– sanitation of patrimonial ways before childbirth
– prevention of gynecologic infections before surgical manipulations

the Route of administration and
Intravaginalno’s doses. On one suppository of 1 times a day before going to bed within 6 days. If necessary the course of treatment is repeated after consultation of the doctor. For sanitation of patrimonial ways the single use of one suppository

Side effects
– hyperaemia and hypostasis of a mucous membrane
– discharge from a vagina
– an itching, burning
– the speeded-up urination
– intercurrent cystitis

of the Contraindication
– hypersensitivity to Clotrimazolum is recommended
– the I trimester of pregnancy, the lactation period

Medicinal interactions
At simultaneous use Clotrimazolum reduces efficiency of Amphotericinum B and other half-yen antibiotics. The activity of Clotrimazolum decreases at simultaneous use with nystatin.

Special instructions
For prevention of reinfection it is necessary to carry out simultaneous treatment of sexual partners.
In trichomoniasis the combined reception with system chemotherapeutic means is recommended (metronidazole inside).
Emergence of the significant local reactions (irritation) or signs of hypersensitivity demands the treatment termination.
In the absence of clinical improvement within 4 weeks it is necessary to conduct a microbiological research for specification of the diagnosis.
It is not recommended to use drug in the period of periods.
In the presence of a simultaneous infection of external genitalias (vulvar lips, a vulva) the intravaginalny use of suppositories is recommended to be combined with topical external use of Clotrimazolum in the form of cream.
At patients with a liver failure it is necessary to check a functional condition of a liver periodically.
Safety and efficiency of use for children is not established
Pregnancy and the period of a lactation
the Question of expediency of prescribing of drug in II and III trimesters
of pregnancy has to be solved individually the doctor. For the period of treatment stop feeding by a breast.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
Use of drug does not affect ability to driving of motor transport and control of potentially dangerous mechanisms.

The overdose
Due to the low absorption of drug overdose at intravaginalny use is improbable.
Topical administration of drug in the doses exceeding the recommended dosage

the Form of release and packing
On 6 suppositories in blister strip packaging from a film polyvinylchloride laminated by polyethylene does not cause life-threatening reactions.
On 1 blister strip packaging together with the instruction for medical use in the state and Russian languages put in a pack cardboard.

To Store storage conditions in the dry, protected from light place, at
a temperature from 15 – 25 °C.
To store out of children’s reach!

A period of storage
3 years
not to use after an expiration date

Prescription status
Without prescription

LLC PHARMAPRIM Producer, Moldova
MD-2028, Chisinau, G. Tudor St., 3

the Owner of the registration certificate

the Address of the organization accepting claims from consumers on quality of products:
Representative of firm: Tatyana Abulkhairova
of Mr. Alata, m / r Aynabulak-1, house 20, apartment 67
Phone number / fax: 252-64-13, 8-777-242-46-49

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