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Chophytol® (Artichoke) 180 coated tablets




One tablet contains

  • Active ingredient – Artichoke (dry, aqueous leaf extract) 200.0 mg
  • Auxiliary substances: magnesium trisilicate, pregelatinized corn starch, talc, magnesium stearate, gummilac (shellac), rosin, gelatin, sucrose, calcium carbonate, dispersed dye, carnauba wax, polysorbate 80.


Pharmacological properties


Due to the fact that artichoke extract contains a complex of biologically active substances, including: polyphenolic substances (luteolin, cynarin, caffeic, chlorogenic and ferulic acids), bioflavonoids, inulin, minerals and trace elements, vitamins, sesquiterpenlactones, and the effect of the drug is caused by the combined action of all its components, carrying out kinetic studies is not possible; all components cannot be traced using markers or bio-research. For the same reason, it is impossible to detect all the metabolites of the drug.



The pharmacological effect of the drug is due to the complex of biologically active substances that make up the field artichoke.

Pharmacodynamic studies indicate choleretic, hepatoprotective, antioxidant, mild diuretic, hypocholesterolemic effects.

The complex effect of polyphenolic substances, such as luteolin, cynarin, caffeic, chlorogenic and ferulic acids, prevents cholesterol biosynthesis by specifically blocking the activation of hydroxymethylglutaryl-CoA reductase by insulin, without affecting other insulin-dependent phenomena (such as lactic acid synthesis).

Caffeic acid reduces the level of aflatoxin synthesized by pathogenic fungal flora.

Chlorogenic acid, a derivative of caffeic acid, slows down the release of glucose in the blood after a meal and inhibits glucose-6-phosphatase, decreasing hepatic glycogenolysis.

Ferulic acid, a methylated form of caffeic acid and a component of lignocellulose, binds lignin to polysaccharides. Ferulic acid derivatives scolimozide and scopoletin normalize blood pressure, have an anti-inflammatory effect, and increase the level of serotonin, the main endogenous antidepressant.

Tsinarin, cyanidin, cyanopicrin are more complex derivatives of caffeic acid, have antioxidant, choleretic, spasmolytic, hepatoprotective effects, increase the evacuation of bile, and reduce cholesterol levels.

The bioflavonoids luteolin, apigenin, hesperidin, quercetin and rutin are antioxidants with anti-inflammatory effects.

Luteolin and apigenin promote the metabolism of carbohydrates, inhibit the production and secretion of anti-inflammatory cytokines TNF-alpha and interleukins IL-1beta, IL-6, IL-4, IL-13.

Apigenin blocks the formation of uric acid.

Hesperidin reduces total cholesterol and blood pressure. Quercetin slows down the synthesis and secretion of histamine, inhibits the enzyme lipoxygenase and cytochrome CYP3A4.

The minerals and trace elements contained in the artichoke: calcium, potassium, magnesium, iron, ascorbic acid, as well as carotene, vitamins B1 and B2, inulin contribute to the normalization of metabolic processes.

The high content of potassium in relation to sodium has a positive effect on salt metabolism.

Inulin stimulates the immune system, increases the absorption of minerals (especially calcium), reduces the risk of atherosclerosis, and modulates the levels of carbohydrate metabolic hormones insulin and glucagon. The mechanism of action is due to the effect of inulin metabolism products on cellular proteins. The decrease in the level of triglycerides in the blood and liver occurs through a decrease in the secretion of very low density lipoprotein from the liver as a result of a decrease in the activity of lipogenic enzymes. The activity of these enzymes is reduced through direct inulin inulin inhibition by metabolites.

Sesquiterpenlactones improve the glomerular filtration capacity of the kidneys, have a mild potassium-sparing diuretic effect, increase diuresis and the release of end products of nitrogen metabolism and liver detoxification products.


Indications for use

As part of complex therapy
– hypokinetic biliary dyskinesia
– chronic non-calculous cholecystitis
– chronic hepatitis
– chronic nephritis


Method of administration and dosage


Adults and children over 12 years old take 2-3 tablets 3 times a day before meals.

Children from 6 to 12 years old take 1 tablet 3 times a day before meals.

The duration of the course of treatment is 2-3 weeks.


Side effects

– allergic reactions (skin rash, itching)

With long-term use in high doses

– diarrhea
– stomach ache.



– hypersensitivity to drug components
– cholelithiasis
– obstructive jaundice
– acute diseases of the liver, kidneys, bile and urinary tract
– chronic liver failure
– children under 6 years of age


Special instructions

Pregnancy and lactation

The use of the drug during pregnancy is possible when the intended benefit to the mother outweighs the potential risk to the fetus.

Allowed for use during lactation.



Symptoms: diarrhea, abdominal pain.
Treatment: drug withdrawal, symptomatic therapy.


Storage conditions

At a temperature not higher than 25 0С.
Keep out of the reach of children!

Shelf life – 3 years
Do not use after the expiration date printed on the package.

Additional information



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