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Amlong 10 mg (30 tablets)




The instruction for medical use

of AMLONG medicine

the Trade name
of Amlong

The international unlicensed

name Amlodipin Lekarstvennaya
the Tablet form on 5 mg, 10 mg

One tablet contains
active agent – an amlodipin besilat 5 mg, 10 mg,
excipients: microcrystalline cellulose, calcium dihydrophosphate, sodium of starch glikolit, magnesium the stearate, povidone, talc purified of silicon dioxide anhydrous (aerosil).

The description
of the Tablet of white color, flat round, with a facet and risky on one party.

Pharmacotherapeutic group
Blockers of slow calcium channels. Selection dihydropyridinic derivatives.
The code of automatic telephone exchange C08CA01

the Pharmacological

Pharmacokinetics Later properties of intake Amlodipin is well adsorbed, reaching the peak of concentration in blood between 6-12 hours. Amlodipin well gets into bodies and body tissues. Elimination half-life of 35-50 hours that allows to appoint it 1 time a day. Plasma reaches steady level in 7-8 days of daily reception. 95-98% of drug contact proteins of blood plasma. The bioavailability is 63-80%. It Biotransformirutsya in a liver to inactive metabolites, it is brought out of an organism with urine: 10% of a dose in not changed look and 60% in the form of inactive metabolites.

A pharmacodynamics
Amlodipin – derivative dihydropyridine. Possesses antihypertensive, anti-anginal, spasmolytic and vasodilating action. Blocks receipt of calcium ions through cellular membranes in smooth muscle cells of a myocardium and vessels. The mechanism of hypotensive action is caused by the direct weakening impact on smooth muscles of vessels. The anti-anginal effect of drug is caused by its ability to expand peripheral arterioles that leads to decrease in the general peripheric vascular resistance. Reduction of load of heart leads to decrease in need of a myocardium for oxygen. Amlong has anti-atherosclerotic, antitrombotichesky activity, increases glomerular filtration rate, possesses weak natriuretic effect.


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