The instruction for use
medicine for experts
УЛКАРИЛ®
Trade name
УЛКАРИЛ®
the International unlicensed
name Acyclovir Dosage Form 5% Cream Structure of 1 G of Cream contain
active agent - acyclovir of 0.05 g,
excipients: ketostearyl alcohol, half-oxameasures 407, vaseline white, oil mineral, propylene glycol, sodium lauryl sulfate, water purified.
Description
Homogeneous cream of white color, flavourless
Pharmacotherapeutic group
Antiviral means of direct action. Nucleosides and nucleotides.
The code of automatic telephone exchange J05AB01
the Pharmacological
Pharmacokinetics At properties topical administration acyclovir is slightly soaked up through skin and mucous membranes.
The pharmacodynamics
Acyclovir is a synthetic analog of a nucleoside of thymidine. The thymidinekinase of the cells infected with a virus, will actively transform acyclovir through a number of consecutive reactions to mono - di - and acyclovir triphosphate. Triphosphate of acyclovir is built in instead of a deoxyguanosine virus DNA, inhibits a DNA polymerase of the last and suppresses replication process. In herpes acyclovir prevents formation of new elements of rash, reduces the probability of skin dissimination and visceral complications, accelerates formation of crusts. Promotes decrease in pain in a sharp phase of the surrounding herpes. The specificity and very high selectivity of action is also caused by its primary accumulation in the cells affected with a herpes virus. The activity of acyclovir against a herpes simplex virus (type 1) is twice higher, than at Cytarabinum, by 10 times — than at an idoksuridin, by 15 times — than at a trifluorotimidin and by 160 times — than at a vidarabin. It is highly active concerning a virus of a herpes simplex (Herpes simplex (VHS)) of type 1 and 2, a virus of chicken pox and shingles (Varicella zoster (VZV)), a virus Epshtayn-Barra. It is moderately active concerning a cytomegalovirus.
Indications
- the integument infections caused by the Herpes simplex virus
- primary and secondary genital herpes
- shingles
- chicken pox
- herpes of lips
the Route of administration and doses
Adults and children need to apply cream on an affected area of 6 times a day each 3 hours, excepting night time. Treatment needs to be begun at the first symptoms of an infection – during a prodromal stage. A course of treatment - 7 days.
Before putting cream it is necessary to wash up hands, it is important not to pound affected areas and not to touch them with a towel to prevent deterioration in a course of the disease or transmission of infection.
Side effects
- reddening
- an itching
- peeling
- burning or pricking
Is rare
- allergic dermatitis
of the Contraindication
- hypersensitivity or intolerance of components
of drug
Medicinal interactions
At external use of Ulkaril® the interaction with other medicines is not revealed.
Special instructions
it is not necessary to exceed the recommended dosage, frequency of appliques and duration of treatment.
Улкарил®, 5% cream should not be applied to prevention of a recurrence of the infection caused by a herpes simplex virus.
To the persons having herpes on lips (especially in the presence of open defeats), it is necessary to follow strictly rules of precaution not to allow infection of other people.
Улкарил®, 5% cream is intended only for drawing on integuments, it an eye is not recommended to apply on mucous membranes of an oral cavity, genitalias as development of the significant local inflammation is possible.
The efficiency of treatment at cream use by that will be higher, than earlier it is begun
Pregnancy and a lactation
women Should be careful when prescribing Ulkaril® cream during pregnancy and to estimate expected advantage for mother and possible risk for a fruit.
It is unknown whether acyclovir in breast milk at topical administration is emitted. It is necessary to appoint with care cream to the feeding women.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
Drug does not affect ability to run the vehicle and work with potentially dangerous mechanisms.
Overdose
Now about cases of overdose of 5% of ULKARIL® cream it was not reported
the Form of release and packing
of 5% cream in aluminum tubas on 5 g and 10 g in a cardboard pack together with the instruction for use.
To Store storage conditions at a temperature not over 250 With in the dry, protected from light place.
To store out of children's reach!
An expiration date
2 years
not to apply after an expiration date
Prescription status
Without prescription
Republic of Kazakhstan JSC Nobel Almatinskaya Pharmatsevticheskaya Fabrika Producer
Almaty, Shevchenko St., 162 E.
medicine for experts
УЛКАРИЛ®
Trade name
УЛКАРИЛ®
the International unlicensed
name Acyclovir Dosage Form 5% Cream Structure of 1 G of Cream contain
active agent - acyclovir of 0.05 g,
excipients: ketostearyl alcohol, half-oxameasures 407, vaseline white, oil mineral, propylene glycol, sodium lauryl sulfate, water purified.
Description
Homogeneous cream of white color, flavourless
Pharmacotherapeutic group
Antiviral means of direct action. Nucleosides and nucleotides.
The code of automatic telephone exchange J05AB01
the Pharmacological
Pharmacokinetics At properties topical administration acyclovir is slightly soaked up through skin and mucous membranes.
The pharmacodynamics
Acyclovir is a synthetic analog of a nucleoside of thymidine. The thymidinekinase of the cells infected with a virus, will actively transform acyclovir through a number of consecutive reactions to mono - di - and acyclovir triphosphate. Triphosphate of acyclovir is built in instead of a deoxyguanosine virus DNA, inhibits a DNA polymerase of the last and suppresses replication process. In herpes acyclovir prevents formation of new elements of rash, reduces the probability of skin dissimination and visceral complications, accelerates formation of crusts. Promotes decrease in pain in a sharp phase of the surrounding herpes. The specificity and very high selectivity of action is also caused by its primary accumulation in the cells affected with a herpes virus. The activity of acyclovir against a herpes simplex virus (type 1) is twice higher, than at Cytarabinum, by 10 times — than at an idoksuridin, by 15 times — than at a trifluorotimidin and by 160 times — than at a vidarabin. It is highly active concerning a virus of a herpes simplex (Herpes simplex (VHS)) of type 1 and 2, a virus of chicken pox and shingles (Varicella zoster (VZV)), a virus Epshtayn-Barra. It is moderately active concerning a cytomegalovirus.
Indications
- the integument infections caused by the Herpes simplex virus
- primary and secondary genital herpes
- shingles
- chicken pox
- herpes of lips
the Route of administration and doses
Adults and children need to apply cream on an affected area of 6 times a day each 3 hours, excepting night time. Treatment needs to be begun at the first symptoms of an infection – during a prodromal stage. A course of treatment - 7 days.
Before putting cream it is necessary to wash up hands, it is important not to pound affected areas and not to touch them with a towel to prevent deterioration in a course of the disease or transmission of infection.
Side effects
- reddening
- an itching
- peeling
- burning or pricking
Is rare
- allergic dermatitis
of the Contraindication
- hypersensitivity or intolerance of components
of drug
Medicinal interactions
At external use of Ulkaril® the interaction with other medicines is not revealed.
Special instructions
it is not necessary to exceed the recommended dosage, frequency of appliques and duration of treatment.
Улкарил®, 5% cream should not be applied to prevention of a recurrence of the infection caused by a herpes simplex virus.
To the persons having herpes on lips (especially in the presence of open defeats), it is necessary to follow strictly rules of precaution not to allow infection of other people.
Улкарил®, 5% cream is intended only for drawing on integuments, it an eye is not recommended to apply on mucous membranes of an oral cavity, genitalias as development of the significant local inflammation is possible.
The efficiency of treatment at cream use by that will be higher, than earlier it is begun
Pregnancy and a lactation
women Should be careful when prescribing Ulkaril® cream during pregnancy and to estimate expected advantage for mother and possible risk for a fruit.
It is unknown whether acyclovir in breast milk at topical administration is emitted. It is necessary to appoint with care cream to the feeding women.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
Drug does not affect ability to run the vehicle and work with potentially dangerous mechanisms.
Overdose
Now about cases of overdose of 5% of ULKARIL® cream it was not reported
the Form of release and packing
of 5% cream in aluminum tubas on 5 g and 10 g in a cardboard pack together with the instruction for use.
To Store storage conditions at a temperature not over 250 With in the dry, protected from light place.
To store out of children's reach!
An expiration date
2 years
not to apply after an expiration date
Prescription status
Without prescription
Republic of Kazakhstan JSC Nobel Almatinskaya Pharmatsevticheskaya Fabrika Producer
Almaty, Shevchenko St., 162 E.
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