The instruction for medical use of TRAHISAN medicine ® the Trade name of Trahisan® the International unlicensed name Is not present the Dosage form of the Tablet for resorption Structure One tablet contains active agents: lidocaine a hydrochloride – 1.0 mg, a chlorhexidina a digluconate – 1.0 mg, tyrothricin – 0.5 mg, excipients: sorbitol, magnesium stearate, oil mint. The description of the Tablet of white color, round shape, with a flat surface, slanted edge, diameter (13.0 ± 0.2) mm and height (4.0 ± 0.2) mm. The pharmacotherapeutic group Drugs for treatment of diseases of a throat the Code of automatic telephone exchange R02A the Pharmacological Pharmacokinetics Tirotritsin properties collapses gastric juice. At observance of the dosed mode of use of active agent it is not necessary to expect pharmacological relevant concentration in serum. Beginning of effect of lidocaine of a hydrochloride fast. Linking with proteins – 60 - 80%. Elimination half-life – 1-2 hours. After oral administration the high activity of a chlorhexidin in a digestive tract is established. The resorption occurs slowly. Elimination half-life of a chlorhexidin makes 4 days. The pharmacodynamics Drug contains a combination of the substances having antimicrobial properties and mestnoanesteziruyushchy action. Tyrothricin is a mix of the cyclic and linear (alifatichny) polypeptides possessing antibacterial action due to similarity of tyrothricin in structure with endotoxins of spore-forming Bacille brevis. Mix contains up to 70-80% of tyrocidin - the main cyclic decapeptide and 20-30% of gramicidin – neutral linear pentadecapeptide. Tyrocidin possesses bactericidal action. Tyrocidin causes release from bacterial cells of the substances containing nitrogen and phosphorus which, to similarly cationic detergents, destroy an osmotic barrier of a membrane of a bacterial cell. Gramicidin forms kationprovodyashchy channels in a cellular membrane of a bacterium that leads to changes of intracellular concentration of cations and a cytolysis. The Gramitsidinovy component leads to further dissociation of processes of breath of fabrics and oxidizing phosphorylation. The coverage of tyrothricin covers mainly gram-positive cocci, bacteria and different types of mushrooms, in particular Candida albicans. Unlike antibiotics, at use of tyrothricin the cross resistance of microorganisms is not observed. This feature is caused by the mechanism of effect of tyrothricin. Chlorhexidin and his salts possess antibacterial and fungicide action. The mechanism of action of a chlorhexidin is based on his relationship with a cellular cover of microorganisms which properties change after contact with active agent. Chlorhexidin breaks osmotic balance in cells that destroys an activator cell cytoplasmic membrane. Action against some gram-negative bacteria (Pseudomonas, Proteus), yeast, dermatophytes and mycobacteria slightly. Chlorhexidin is inefficient against spores of mushrooms, putrefactive mushrooms, viruses. Lidocaine the hydrochloride is local anesthetic of amide type. Drug causes blockade of natrium channels of nerve fibril owing to what process of depolarization of a membrane of a neuron through active potential is broken. At the same time transfer of excitement in fibers of sensory nerves is blocked. At the long use the efficiency of drug decreases that, perhaps, is caused by changes of a bacterial range of microflora of an oral cavity and a tooth surface. Indications - inflammatory and infectious diseases of a mouth and throat (stomatitis, an ulitis, a periodontal disease, a glossitis, tonsillitis, pharyngitis and other states which are followed by the complicated swallowing) - prevention of an infection before and after surgery in a mouth and throat (extraction of teeth, surgical treatment of gums, tonsilectomy). Trakhisan - tablets for resorption - to accept a route of administration and doses on one tablet each 2 hours. The daily dose for adults and children is more senior than 12 years - 8 tablets, for children from 6 to 12 years - 6 tablets. Symptoms of a disease disappear in several days, however for achievement of lasting therapeutic effect recommend to continue therapy for 2 - 3 days. If in 5 days of use of drug, improvement of a state did not follow, it is necessary to change treatment tactics. Side effects - the short-term changes of taste, numbness of language passing through short time - insignificant coloring in yellow or light brown color of teeth, fillings and prostheses or language which can be eliminated by means of hygiene of an oral cavity. Coloring disappears spontaneously after the termination of administration of drug. Contraindications - hypersensitivity to any ingredient of drug - injuries of a mucous membrane of an oral cavity (erosion) - open wounds in an oral and pharyngeal cavity - the children's age to 6 is put Medicinal interactions So far Special instructions Drug are unknown the patients having diabetes can use. Pregnancy and the period of a lactation Use of drug during pregnancy and a lactation is possible in case the expected advantage for mother exceeds potential risk for a fruit and the child. Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms the Overdose At accidental use of excessive quantity of tablets does not influence gastric lavage is recommended. A form of release and packing On 10 tablets in blister strip packaging from a film of polyvinylchloride and aluminum foil. On 2 planimetric packs together with the instruction for medical use in the state and Russian languages put in a pack from cardboard. To Store storage conditions at a temperature not over 25 ºС. To store out of children's reach! 3 years not to apply a period of storage until expiry date. Prescription status Without prescription of Proizvoditel Engelhard Artsnaymittel GmbH & Co. KG. Hertsbergstrasse 3, 61138 Niderdorfelden, Germany. Owner of the registration certificate of Engelhard Artsnaymittel GmbH & Co. KG. Hertsbergstrasse 3, 61138 Niderdorfelden, Germany. The Esklyuzivny representative of Alpen Pharm AG Bern, Switzerland the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) of Alpen Pharm LLP of Almaty, mdt. Zhetysu-2, 80, quarter 54 Ph./fax + 7 727 2265306 E-mail: info. kazakhstan@alpenpharma.com
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