Tirfens 20s 80 mg coated tablets

The instruction for medical use of TIRFENS medicine the Trade name of Tirfens the International unlicensed name Fenspirid Lekarstvennaya the Tablet form, coated 80 mg Structure One tablet contains active agent - a fenspirid a hydrochloride of 80 mg, excipients: cellulose microcrystalline (PH 101), a karmelloza of calcium, K30 povidone, cellulose microcrystalline (PH 102), croscarmellose sodium, silicon dioxide colloidal anhydrous, magnesium stearate, water purified structure of a cover: Опадри® II white 85F18422 (the polyvinyl alcohol which is partially hydrolyzed the titan E171 dioxide, makrogol/PEG, talc). The description of the Tablet of round shape, with a biconvex surface, film coated white color. Pharmacotherapeutic group Drugs for treatment of obstructive respiratory diseases. Other drugs for treatment of obstructive respiratory diseases for system use. Fenspirid. The ATX R03DX03 code the Pharmacological Pharmacokinetics Later properties of intake the maximum concentration of a fenspirid in blood plasma is reached in 6 hours. Elimination half-life makes about 12 hours. It is removed mainly with urine (90%), through intestines (10%). The pharmacodynamics of Tirfens possesses bronkhodilatiruyushchy and anti-inflammatory action due to antagonistic activity at the level of H1-histamine receptors and papaverinopodobny spasmolytic effect. Anti-inflammatory action is result of decrease in products of pro-inflammatory factors (cytokines, a tumornekrotiruyushchy factor an alpha - TNFα, derivatives of arachidonic acid and free radicals) some of which have bronkhokonstriktorny effect. Indications - treatment of acute and chronic inflammatory processes of ENT organs and airways (otitis, sinusitis, rhinitis, a nasopharyngitis, tracheitis, rinotrakheobronkhit, bronchitis) - seasonal and year-round allergic rhinitis and other manifestations of an allergy from a respiratory system and ENT organs - the respiratory phenomena in measles, whooping cough, flu (cough, a voice osiplost, irritation in a throat). As maintenance therapy in asthma and its complications. The route of administration and doses take the Drug inside, to food, washing down with enough liquid. The adult appoint on 1 tablet 2 times a day (in the morning and in the evening). For stronger effect and/or in acute form of a disease - on 1 tablet 3 times a day (in the morning, in the afternoon, in the evening). Side effects the Used lower than the parameters of frequency of side effects are defined as follows: often (≥ 1/100, & lt, 1/10), it is rare (≥ 1/10000, & lt, 1/1000), unspecified frequency. Often - nausea, stomach aches it is rare - the moderate tachycardia stopping at a dose decline - drowsiness - allergic reactions: the erythema, rash, a small tortoiseshell, a Quincke's edema, the fixed pigmentary erythema Frequency is not established - diarrhea, vomiting - an asthenia, fatigue, dizziness - the cardiopalmus and hypotension which are perhaps connected with tachycardia - a skin itching, a toxic epidermal necrolysis, sindros Stephens-Johnson of the Contraindication - hypersensitivity to a fenspirid and/or other components of drug Medicinal interactions Interaction of a fenspirid with other medicines is unknown. Simultaneous use with sedatives owing to potentiation of sedation is not recommended. Enhances sedation of antihistamines. The special instructions Drug treatment does not replace antibiotic treatment. Use in pediatrics of Tirfens in the form of tablets it is not intended for treatment of children. For drug use it is recommended to children in the form of syrup. Pregnancy and a lactation At the moment are not present the clinical data confirming ability of a fenspirid to cause toxicity or maldevelopment of a fruit at administration of drug during pregnancy. Therefore reception of a fenspirid during pregnancy is not recommended though confirmation of pregnancy at reception of a fenspirid does not demand termination of pregnancy. At the moment there are no authentic data on discharge of a fenspirid with breast milk. Therefore purpose of a fenspirid is not recommended to the women nursing. As fenspirid drowsiness can cause features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms, it is necessary to show care at control of motor transport or other mechanisms, especially at the beginning of therapy. Overdose Symptoms: drowsiness or excitement, nausea, vomiting, sinus tachycardia. Treatment: gastric lavage, monitoring of the electrocardiogram. Symptomatic therapy. The form of release and packing On 10 tablets in place in blister strip packaging from a film of polyvinylchloride and aluminum foil. On 2 or 3 blister strip packagings together with the instruction for medical use in the state and Russian languages place in a pack from cardboard. To Store storage conditions at a temperature not above 25 °C. To store out of children's reach! 3 years not to apply a period of storage after an expiration date. Prescription status According to the prescription the Producer/packer UORLD of ILACh DIGNITY MEDICINE. VE TIDZh. A.Sh., TURKEY (Bagdzhylar Ilchesi, Gyuneshli, Evren Makhallesi, Dzhami Yolu Dzhad. No. 50 K. 1B Zemin 4-5-6, Istanbul) WORLD MEDICINE İLAÇ SAN. VE TİC. A.Ş., TURKEY (Bağcılar İlçesi, Güneşli, Evren Mahallesi, Cami Yolu Cad. No: 50 K. 1B of Zemin 4-5-6, İstanbul). Owner of the registration certificate UORLD of ILACh DIGNITY MEDICINE. VE TIDZh. A.Sh., TURKEY the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products: RIN Pharm LLP, RK, Almaty, Suyunbaya Ave., 222 B Ph. / fax: +7 (727) 2529090 Address of the organization responsible for post-registration observation of safety of medicine: TROKA-S PHARMA LLP, RK, Almaty, Suyunbaya Ave., 222 B Cellular ph. +7 701 786 33 98, (24-hour access). e-mail: pvpharma@worldmedicine.kz