TAVEGYL® (Clemastine) 1 mg, 20 tablets

  • $10.20
Sku: d0aab60ba549
Ingredient: Clemastine
Other brand names: Agasten, Allerhist, Antamin, Tavegil, Tavist, DAYHIST-1, Benanzyl


1 tablet contains:
Active substances - 1 mg of Clemastine, which is equivalent to 1.34 mg of clemastine hydrogen fumarate;
auxiliary substances - lactose monohydrate, povidone (polyvinylpyrrolidone), corn starch, magnesium stearate, talc.


Pharmacological properties

H1-histamine blocker is an ethanolamine derivative. It has antiallergic and antipruritic effect, reduces vascular permeability, has a sedative and M-anticholinergic effect, does not have hypnotic activity. Prevents the development of vasodilation and smooth muscle contraction induced by histamine. Reduces capillary permeability, inhibits exudation and edema formation, reduces itching. The antihistaminic activity of the drug reaches a maximum after 5-7 hours, lasts for 10-12 hours, and in some cases - up to 24 hours.

After oral administration, clemastine is almost completely absorbed from the gastrointestinal tract. The maximum plasma concentration is reached after 2-4 hours.

The connection with plasma proteins is 95%. Excretion from plasma is biphasic, the corresponding half-lives are 3.6 ± 0.9 hours and 37 ± 16 hours. Clemastine undergoes significant liver metabolism. Metabolites are mainly (45-65%) excreted through the kidneys in the urine; unchanged active substance is found in urine only in trace amounts. During lactation, a small amount of clemastine may pass into breast milk.


Indications for use

  • Hay fever (allergic rhinoconjunctivitis).

  • Hives of various origins.

  • Itching, itchy dermatoses.

  • Acute and chronic eczema, contact dermatitis.

  • Drug allergy.

  • Insect bites and stings



Hypersensitivity, taking MAO inhibitors, diseases of the lower respiratory tract (including bronchial asthma).
Tavegil should not be used in women while breastfeeding.

Tavegil (tablets) should not be used in children under the age of 6 years (from the age of 1 year, you can use Tavegil syrup and injection solution).

With caution: in patients with stenosing gastric ulcer, pyloroduodenal obstruction, with obstruction of the bladder neck, as well as prostatic hypertrophy, accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system, including arterial hypertension.

Application during pregnancy

During pregnancy, Tavegil® is used only if the expected benefit to the mother outweighs the potential risk to the fetus.


Method of administration and dosage

Adults and children over 12 years of age are prescribed 1 tablet (1 mg) in the morning and in the evening. In cases that are difficult to treat, the daily dose can be up to 6 tablets (6 mg). The tablets should be taken before meals with water.

Children aged 6-12 years are prescribed 1/2-1 tablet before breakfast and at night.


Possible side effects

From the side of the central nervous system: possible - increased fatigue, drowsiness, headache, dizziness, tremors, sedation, weakness, fatigue, lethargy, impaired coordination of movements. In rare cases, especially in children, a stimulating effect on the central nervous system is noted: anxiety, increased irritability, agitation, nervousness, insomnia, hysteria, euphoria, convulsions, parasthesia, neuritis.

From the gastrointestinal tract: dyspepsia, nausea, epigastric pain, constipation, vomiting; rarely dry mouth. There are isolated cases of decreased appetite and diarrhea.

From the senses: impaired clarity of visual perception, diplopia, acute labyrinthitis, tinnitus.

From the urinary system: very rarely - frequent or difficult urination.

On the part of the respiratory system: rarely - thickening of bronchial secretions and difficulty in sputum discharge, a feeling of pressure in the chest and difficulty breathing, nasal congestion.

From the side of the cardiovascular system: rarely - a decrease in blood pressure (more often in elderly patients), palpitations, extrasystoles.

From the side of hematopoiesis: hemolytic anemia, thrombocytopenia, agranulocytosis.

Allergic reactions: very rarely - urticaria, skin rash, photosensitivity, anaphylactic shock.




An overdose of antihistamines can lead to both a depressing and a stimulating effect on the central nervous system, which is more often observed in children. Anticholinergic effects may also develop: dry mouth, fixed pupil dilation, rush of blood to the upper half of the body, disorders of the gastrointestinal tract (nausea, epigastric pain, vomiting).


If the patient does not vomit spontaneously, then it should be induced (only if the patient's consciousness is preserved). If 3 hours or more have passed since taking the drug, it is necessary to wash the stomach using 0.9% sodium chloride solution and activated carbon. A saline laxative may also be prescribed. Shown like the same symptomatic therapy.


Interaction with other medicinal products

Tavegil enhances the effect of drugs that depress the central nervous system (hypnotics, sedatives, anxiolytics), M-anticholinergics, and alcohol. Not compatible with the simultaneous administration of MAO inhibitors.


Special instructions

To prevent distortion of the results of skin scarification tests for allergens, the drug must be canceled 72 hours before the allergy test.

Patients taking Tavegil are advised to refrain from driving vehicles, working with mechanisms, as well as from other activities that require increased concentration of attention and speed of psychomotor reactions.


Storage conditions

At a temperature not exceeding 30°C, out of the reach of children.
The shelf life is 5 years. Do not use after the expiration date.
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