Strike pain 65 mg + 500 mg (10 tablets)

The instruction for medical use of medicine the Strike from pain the Trade name the Strike from pain the International unlicensed name Is not present. Dosage form of the Tablet OpisanieTabletki of oblong shape, white or yellow-white color, 16 mm long. Composition of drug One tablet contains active agents: paracetamol of 500 mg, caffeine of 65 mg. excipients: starch corn prezhelatinizirovanny, K25 povidone, kroskarmelloz sodium, cellulose microcrystalline, silicon dioxide colloidal, magnesium stearate Pharmacotherapeutic group Nervous system. Analgetics. Other analgetics and anti-retics. Anilides. Paracetamol, combinations from psikholeptika. The ATX N02BE71 code the Pharmacological Pharmacokinetics Paracetamol properties – is quickly and almost completely soaked up (96%) from digestive tract. Paracetamol gets through a fetoplacental barrier and is emitted with breast milk in insignificant quantities. By researches it is established that paracetamol has no genotoksichesky and teratogenic effect. The maximum concentration in blood about 6 mkg/ml, time of achievement of the maximum concentration of 10-60 min. Linking with proteins of plasma in therapeutic concentration is minimum. Paracetamol is metabolized in a liver, its most part enters conjugation tests with glucuronic acid and sulfates with formation of inactive metabolites and is removed with urine in the form of sulphatic and glucuronic conjugates. The semi-elimination period (including at elderly) averages 2.3 h. Caffeine – is quickly soaked up at oral administration, the maximum concentration in blood plasma is reached within one hour, elimination half-life makes about 4.9 hours. 65-80% of the accepted caffeine are removed with urine in the form of 1-methyl-uric acid and 1 methylxanthine. A pharmacodynamics Paracetamol – analgetic-antipyretic. Renders the anesthetizing and febrifugal effect by suppression of synthesis of prostaglandins in a hypothalamus. In this regard, use of paracetamol is especially reasonable at patients for whom suppression of synthesis of prostaglandins in peripheral fabrics is undesirable, for example, in the presence in the anamnesis of gastrointestinal bleedings or at elderly patients. Caffeine belongs to group of alkaloids (methylxanthines). Possesses psychogogic and analeptical action. In a combination with analgetics, in particular, with paracetamol, enhances its analgesic effect. Drug does not affect water salt metabolism as does not influence synthesis of prostaglandins in peripheral fabrics. Indications Pain syndrome easy and moderately severe: a headache, migraine, a toothache, pain after odontectomy or other dental interventions, pain in osteoarthrites, muscle and joints pain, a sore throat, painful periods. Feverish syndrome: the increased temperature and pain in catarrhal diseases and flu and also after vaccination. A route of administration and doses of the Tablet Strike from Pain 3-4 times a day take inside usually 1-2 pill if it is necessary. An interval between receptions – not less than 4 hours. The maximum single dose - 2 tablets, the maximum daily dose – 8 tablets. To children at the age of 14-15 years: 1 tablet to four times a day. An interval between receptions – not less than 4 hours. No more than 4 tablets within 24 hours. Drug is not recommended to apply more than five days as anesthetic and more than three days as febrifugal without appointment and observation of the doctor. Duration of treatment are possible only under observation of the doctor. If symptoms remain, it is necessary to see a doctor. It is not necessary to exceed the specified dose. In case of overdose it is necessary to see immediately a doctor even if you feel well. Collateral action is Very rare (& lt, 1/10.000) - thrombocytopenia - anaphylactic reactions - skin reactions of hypersensitivity, including skin rash, a Quincke's disease, Stephens-Johnson's syndrome - a bronchospasm at patients with hypersensitivity to acetylsalicylic acid and other NPVP - abnormal liver functions Frequency is unknown - nervousness - dizziness can lead the Concomitant use of drug with kofeinsoderzhashchy products (for example, coffee, tea, kofeinsoderzhashchy drinks) to a sleep disorder, concern, irritability, a headache, gastrointestinal disorders and a cardiopalmus. It is necessary to stop administration of drug and to see immediately a doctor at emergence of above-mentioned reactions and also emergence of peeling, ulcers in an oral cavity, difficulties of breath, hematomas, krovototecheniye or any other undesirable reaction to drug. Contraindications - hypersensitivity - heavy abnormal liver functions or kidneys - genetic absence dehydrogenase glyukozo-6-phosphate - blood diseases - arterial hypertension, the expressed phenomena of atherosclerosis - pregnancy and the period of breastfeeding - with care should be applied to drug components at Gilbert's syndrome (constitutional hyperbilirubinemia) - glaucoma - sleep disorders - the children's age up to 14 years Medicinal interactions At reception for a long time drug strengthens effect of indirect anticoagulants (warfarin and other coumarins) that increases risk of bleedings. Inductors of microsomal oxidation of a liver (barbiturates, Phenytoinum, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants) increase risk of hepatotoxic action at overdoses. Inhibitors of microsomal oxidation (Cimetidinum) reduce risk of hepatotoxic action. Under the influence of paracetamol time of removal of chloramphenicol increases by 5 times. Caffeine accelerates ergotamine absorption. The concomitant use of paracetamol and alcoholic beverages increases risk of development of hepatotoxic effects and acute pancreatitis. Metoclopramidum and domperidon is increased, and holestiramin reduces paracetamol absorption speed. Drug can reduce efficiency of uricosuric drugs. Special instructions during administration of drug the excess consumption of tea and coffee as it can lead to excitement, a sleep disorder, tachycardia, cardiac arrhythmia is not recommended. In order to avoid TOXIC DAMAGE of the LIVER, PARACETAMOL SHOULD not be COMBINED WITH INTAKE of ALCOHOLIC BEVERAGES AND ALSO to ACCEPT to the PERSONS INCLINED TO CHRONIC CONSUMPTION of ALCOHOL. Before administration of drug it is necessary to consult with the doctor: - to the patients taking warfarin or other drugs for decrease in blood clotting - patients with chronic diseases of a liver or kidneys, - if the headache becomes a constant. It is not recommended to accept along with other drugs containing paracetamol. In case of exceeding the recommended dose, paracetamol can have the damaging effect on a liver. Use of paracetamol at the states reducing glutathione level (for example, in sepsis) increases risk of developing of a metabolic acidosis. At emergence of a combination of the following symptoms: - the deep, speeded-up, complicated breath - feeling sick (nausea, vomiting) - loss of appetite it is necessary to see a doctor. Pregnancy and the period of a lactation Drug is not used at pregnancy in connection with possible risk of spontaneous termination of pregnancy at the caffeine use. It is necessary to avoid administration of drug during breastfeeding as caffeine is emitted with breast milk and can cause excitement in the child. There is no feature of influence of drug on ability to run the vehicle or potentially dangerous mechanisms of Restrictions on driving of the car and work with mechanisms. Overdose Paracetamol Symptoms: nausea, vomiting, stomach aches, perspiration, pallor of integuments. In 1-2 days, signs of damage of a liver are defined (morbidity in a liver, increase in activity of hepatic enzymes). In hard cases the liver failure, encephalopathy and coma develops. Treatment: to stop administration of drug and to see immediately a doctor. Gastric lavage and reception of enterosorbents (activated carbon, Polyphepanum) is recommended. Use of N-Acetylcysteinum or methionine is possible. Caffeine Symptoms: pain in epigastric area, nausea, frequent urination, tachycardia or arrhythmia, symptoms of stimulation of central nervous system (insomnia, nervousness, concern, hyperexcitability, a nervous trembling, a tremor and spasms). Treatment: Symptomatic therapy. There is no specific antidote. Use of antagonists of β-adrenoceptors can reduce cardiotoxic effect. At accidental overdose it is necessary to ask immediately for medical care, even at good health. A form of release and packing On 10 tablets in blister strip packaging from a film of polyvinylchloride/polyvinyldichloride and aluminum foil. On 1 or 2 planimetric pack together with the instruction for medical use in the state and Russian languages place in a pack from cardboard. To Store storage conditions at a temperature not above 25 °C to Store out of children's reach. Expiration date of 5 years. Not to apply after an expiration date. Prescription status Without prescription Producer Saneca Pharmaceuticals a.s., Nitrianska 10092027 Hlohovec, Slovak Republic of Sanek Pharmasyyutikals of ampere-second., Nitriansk 10092027 Glogovets, the Slovak Republic the Owner of the registration certificate of Ksantis Pharm Limited, Liemiesou, 5 Euroshur the Tower of 1 St of florae, Flet / Office 101 2112, Nicosia, Cyprus the Name, the address and a contact information (phone, the fax, e-mail) of the organization in the territory of the Republic of Kazakhstan, the accepting claim (offer) on quality of medicines from consumers and responsible for post-registration observation of safety medicinal means: Xantis Pharma (Ksantis Pharm) LLP, Kazakhstan 050008, Kazakhstan, Almaty, Auezov St. 48, 3 floor, office 3/2 Phone number, fax: +7 (727) 344 93 14 e-mail:
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