Stopdiar (Nifuroxazide) 200 mg, 12 capsules

The instruction for medical use


of Stopdiar® medicine

the Trade name
of Stopdiar®

the International unlicensed


name Nifuroksazid Lekarstvennaya a form
solid capsules of 200 mg

Structure
One capsule contains
active agent - nifuroksazid 200 mg,
excipients: magnesium stearate, starch corn gelated, sucrose, starch corn,
structure of a lid and body of the capsule: ferrous oxide yellow (E 172), titan dioxide (E 171), gelatin.

The description
solid capsules of a cylindrical form with a yellow lid and the yellow body, No. in size 1. Contents of capsules – granulate of yellow color.

Pharmacotherapeutic group
Antidiarrheal drugs. Intestinal antimicrobial and anti-inflammatory drugs. Other intestinal antimicrobial drugs. Nifuroksazid
the ATX A07AX03 Code

the Pharmacological

Pharmacokinetics Later properties of administration of drug inside, it is practically not absorbed from a GIT, creating high concentration of active ingredient in intestines and showing the antibacterial action only in an intestines gleam. It is completely removed with a stake.
The pharmacodynamics
Nifuroksazid is derivative 5 nitrofurans. He has local antibacterial effect in an intestines gleam concerning gram-positive bacteria from the sort Staphylococcus and gram-negative bacteria from the Enterobacteriaceae family from a sort: Yersinia sp., Escherichia spp., Citobacter spp., Enterobacter spp., Klebsiella spp., Salmonella spp. In sredneterapevtichesky doses has bacteriostatic activity, and in higher – works bakteritsidno.
Nifuroksazid does not show antibacterial action on a look bacterium: Proteus vulgaris, Proteus mirabilis and Pseudomonas aeruginosa.
Nifuroksazid does not destroy saprophytic microflora of a digestive tract, does not break balance of normal indestinal flora. Does not cause emergence of resistant strains. Nifuroksazid has the braking impact on activity of dehydrogenases and protein synthesis in bacteritic cells. The efficiency of drug does not depend from rn in a gut gleam.

Indications
- acute infectious diarrhea at children and adults (intestinal infections and food poisonings) in addition to rehydration

the Route of administration and doses
of Stopdiar®, the capsule is appointed for oral administration. The capsule should be washed down with a small amount of water.
Adult: on 1 capsule 4 times a day, each 6 hours.
To children 7 years are aged more senior: on 1 capsule 3 or 4 of time in every day of 6-8 hours. Maximum daily dose of 800 mg.
Drug course of treatment no more than 7 days. In case of lack of efficiency of drug within 3 days of treatment, consultation of the doctor is necessary for carrying out correction of therapy.
During drug treatment of acute diarrhea, constant oral or intravenous completion of deficiency of liquid in an organism is obligatory (depending on the general condition of the patient).

Side effects
Often
- abdominal pain, nausea, diarrhea
Seldom
- a granulocytopenia
- skin rash, allergic reactions, urticaria, a Quincke's edema, an acute anaphylaxis

of the Contraindication
- the increased individual sensitivity to drug components, including to other derivatives 5 nitrofurans

- children's age up to 7 years
- intolerance of fructose, a glucose galactose sprue, deficiency of invertase-isomaltase

Medicinal interactions
Alcohol intake during the Stopdiar® drug treatment can cause disulfiramopodobny reactions.
During drug treatment it is impossible to accept at the same time other oral medicines in view of expressed the adsorbing properties of drug.

Special instructions
more than 7 days are not recommended to take the Drug Stopdiar®. In case of the proceeding diarrhea after 3 days of treatment the consultation of the doctor is necessary for the solution of a question of tactics of further therapy.
In case of heavy infectious diarrhea, purpose of an antibiotic as the drug Stopdiar® is not soaked up from digestive tract is recommended.
During use of drug it is necessary to keep to a diet with an exception of juice, crude vegetables and fruit, sharp and products hard to digest and dishes.
In case of reaction of supersensitivity (short wind, skin rash, an itching) it is necessary to stop administration of drug. During the Stopdiar® drug treatment the consumption of alcoholic beverages since alcohol increases sensitivity of an organism to drug is contraindicated and can provoke the disulfiramopodobny reaction which is shown exacerbation of diarrhea, vomiting, an abdominal pain, a dermahemia, feeling of heat in the person and in an upper part of a trunk, the noise in the head complicated by breath, tachycardia, feeling of fear.
In some cases, at the available supersensitivity to a nifuroksazid abdominal pain, nausea and strengthening of diarrhea appear. In case of such symptoms, there is no need of use of special therapy or phase-out of a nifuroksazid. If symptoms expressed, it is necessary to stop administration of drug. Such patients should avoid appointment to the patient of derivatives of nitrofuran.
If during drug treatment there are dehydration symptoms, it is necessary to carry out rehydration therapy (taking into account losses of liquid and electrolytes) according to a clinical condition of the patient.
Due to existence in composition of drug of sucrose, patients with the rare inherited disorders connected with intolerance of fructose, a syndrome of a bad resorption of glucose galactose or a lack of invertase-isomaltase should not accept this medicine.
Pregnancy and the period of a lactation
is not recommended administration of drug during pregnancy as there are no sufficient clinical data for assessment of teratogenic or fetotoksichesky effects of a nifuroksazid.
Nifuroksazid is not soaked up from a digestive tract. Nevertheless due to the lack of sufficient clinical data it is necessary to be careful when assigning a nifuroksazid in the period of a lactation.
The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
does not influence.

Overdose
Symptoms: strengthening of side effects.
Treatment: gastric lavage, symptomatic therapy.

A form of release and packing
On 12 capsules in blister strip packaging from aluminum foil and a film polyvinylchloride.
On 1 planimetric packing together with the instruction for medical use in the state and Russian languages put in a cardboard pack.


To Store storage conditions at a temperature from 15 of 0C up to 30 0C.
To store out of children's reach!


2 years
not to use a period of storage after the expiry date specified on packing.

Prescription status
Without prescription

the Name and the country
of the LLC Gideon Richter Polsha manufacturing organization, Poland

the Name and the country of the owner of the registration certificate
of JSC Gideon Richter, Hungary
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products: Representative office of JSC Gideon Richter in RK Almaty, Nurlybayev St. 11 Phone number: 8-(727)-258-26-22, 8-(727)-258-26-23E-mail: info@richter.kz