Siofor® (Metformin) 500 mg (60 coated tablets)

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Siofor® (Metformin) oral tablets are used to treat high blood sugar levels caused by type 2 diabetes. They’re used in combination with diet and exercise. Siofor (Metformin) may be used as part of a combination therapy. That means you may need to take it with other drugs. Metformin allows the body to make better use of the lower amount of insulin which occurs in the kind of diabetes known as type 2 diabetes.

Also known as: Glucophage, Glucophage XR, Glumetza, Fortamet, Meforal®, Metformax®, Metforal®, Metforalmille®, Act Metformin, Metformin, Metformin Hydrochloride, Pg-metformin, Q-metformin, Riomet, Diamin, Formin, Met-500, Bigomet, Bgmet, Diabemet, Kinamet, Glyciphage, Bolamyn®, Diagemet®, Glucient®, Glucorex®, Meijumet®, Metabet®, Metuxtan®, Sukkarto®, Yaltormin®, Obimet, Melmet, Glycomet, Dabex, Carbophage, Biguanil, Carbophage, Cetapin-XR, Cidophage, CO Metformin, Diabesin, Diabex, Diaformin, Dianben, Dimefor, Exermet, Formet, Glafornil, Glifage, Glisulin, Glucofast, Gluconorm-SR, Gluformin, Glumet, Glumet-XR, Glyciphage-SR, Glyformin, Islotin, Meglucon, Metaday, Metbay, Metfogamma, Metforem, Metformin Actavis, Metformin Hexal, Metformin Lich, Metformina Sandoz, Metformine Zentiva, Metformin-ER, Metformin-MR, Metformin-SR, Metformin-XR, MetPro, Metsmall, Metta-SR, Mylan-Metformin, Neodipar, Okamet, Predial, Pro-Metformin, Ratio-Metformin, Riomet-OD, Sandoz Metformin, Siofor, Stagid, Sugamet, Teva-Metformin, Walaphage, XMet-SR

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Contents

One film-coated tablet contains Metformin hydrochloride 500 mg

 

Indications

Non-insulin dependent diabetes mellitus (type 2 diabetes) in case of ineffective diet therapy, especially if you are overweight.
Siofor® 500 can be used both as monotherapy and in combination with other oral antidiabetic agents or insulin.

 

Uses

The dosage of Siofor® 500 and the duration of use is set by the doctor for each patient individually, depending on the level of sugar in the blood and urine.

Therapy is recommended to be carried out with a gradual increase in doses, starting with 1-2 tablets of Siofor® 500 per day (which corresponds to 0.5 g - 1.0 g of metformin hydrochloride). Then, depending on the level of glucose in the blood, the dose of the drug is increased with an interval of one week to an average daily dose of one to six Siofor® 500 tablets per day (which corresponds to 0.5 g to a maximum of 3.0 g of metformin hydrochloride in day).

The maximum single dose is 2 tablets Siofor® 500 (1.0 g of metformin hydrochloride).

Usually, daily doses of three Siofor® 500 tablets per day are sufficient. At doses exceeding
6 tablets Siofor® 500 per day, further increase in efficiency, as a rule, is not achieved.

Film-coated tablets are taken without chewing and with a liquid (for example, a glass of water) during meals. If the required daily dose is more than one tablet, then it should be divided into 2 or 3 doses with meals.

 

Contraindications

- hypersensitivity to metformin or other components of the drug
- diabetic ketoacidosis, diabetic precoma
- severe disorders of liver and kidney function
- myocardial infarction
- cardiovascular insufficiency
- respiratory failure and hypoxic conditions
- diabetic retinopathy
- tumor diseases
- alcoholism
- anemia
- pregnancy and lactation*
- children under 12 years old.

*Pregnancy categories:

C - Australia
B - United States (No evidence of risk in humans)

 

Side effects

- very often (> 10%): nausea, vomiting, diarrhea, abdominal pain, loss of appetite. They appear at the beginning of treatment and in most cases go away on their own. To avoid the onset of these symptoms, it is recommended to take metformin during or after meals in 2 or 3 doses. Discontinuation of treatment is usually not required, since in most cases these symptoms disappear even with an unchanged dosage.
- often (1% -10%): metallic taste in the mouth
- very rare (‹0.01%): mild erythema in patients with hypersensitivity, decreased intestinal absorption of vitamin B12, as well as with long-term treatment - a decrease in its serum concentration, lactic acidosis (0.03 cases / 1000 patients per year ).

Overdose

Symptoms: lactic acidosis, symptoms of which begin with nausea, vomiting, diarrhea, abdominal pain and severe weakness. Muscle pains, rapid breathing, turbidity, and loss of consciousness may occur.

Treatment: The most effective measure to remove lactate and metformin is hemodialysis. Symptomatically, measures are taken to stabilize blood circulation, level acidosis and eliminate hypoxia.

 

How to store Siofor® (Metformin)

Keep all medicines out of the reach and sight of children
Store in a cool, dry place, away from direct heat and light

Shelf life - 3 years