Sekrazol 30 mg (20 tablets)
- $4.40
СЕКРАЗОЛ®
Trade name
СЕКРАЗОЛ®
the International unlicensed
name Ambroxol Dosage Form
of the Tablet of 30 mg
Structure
One tablet contains
active agent – Ambroxol a hydrochloride of 30 mg,
excipients: cellulose microcrystalline
HD90 (Prosolv SMCC HD90), lactose monohydrate, starch prezhelatinizirovanny, magnesium stearate, water
the Pharmacotherapeutic group cleaned the Description Round tablets of white color from risky on one party
Drugs for elimination of symptoms of cold and cough.
Mucolytics.
The code of automatic telephone exchange R05CB06
the Pharmacological
Pharmacokinetics Absorption properties - high, time of achievement of the maximum concentration - 2 hours, communication with proteins of blood plasma - 80%, gets through a blood-brain barrier, a placental barrier, is selected with breast milk.
After intake the action comes in 30 min. and continues within 6-12 hours.
Metabolism - in a liver, forms dibromantranilovy acid and glucuronic conjugates. Elimination half-life – 1.3 hours, and for the prolonged forms - 10-12 hours. It is removed by kidneys: 90% in the form of water-soluble metabolites, in not changed look - 5%.
Elimination half-life increases in heavy chronic kidney disease, but does not change in an abnormal liver function.
The pharmacodynamics
Possesses sekretomotorny, sekretolitichesky and expectorant action, stimulates serous cells of glands of a mucous membrane of bronchial tubes, increases the content of mucous secretion and discharge of surfactant in alveoluses and bronchial tubes, normalizes the broken ratio of serous and mucous components of a phlegm. Activating the hydrolyzing enzymes and strengthening release of lysosomes from cells Klara, reduces viscosity of a phlegm. Increases physical activity of cilia of a ciliary epithelium, increases mukotsiliarny transport of a phlegm.
Indications
- acute and chronic bronchitis
- pneumonia
- a chronic obstructive pulmonary disease
- bronchial asthma with the complicated phlegm otkhozhdeniye
- a bronchoectatic disease
the Route of administration and doses
Inside.
To adults and children 12 years are more senior: on 30 mg (1 tablet) of 3 times/days.
If necessary for strengthening of therapeutic effect it is possible to appoint 60 mg (2 tablets) of 2 times/days.
Children are 6-12 years old – on 15 mg (half of a tablet) 2-3 times a day
Duration of a course of treatment is appointed by the doctor individually.
The drug is taken after a meal, washing down with liquid.
Side effects
Seldom
- a headache
- nausea, vomiting, dryness in a mouth, a gastralgia, diarrhea
- reactions of hypersensitivity (skin rash, a face edema, dispnoe, an itching)
It is very rare
- allergic reactions - a Quincke's disease, an acute anaphylaxis, skin rash, a small tortoiseshell
of the Contraindication
- hypersensitivity to Bromhexine or its metabolite to Ambroxol in
the anamnesis
- a peptic ulcer of a stomach and duodenum in an aggravation stage
- pregnancy (I trimester)
- children's age up to 6 years
Medicinal interactions
Combined use of the drug Sekrazol® with:
- the atropine and other drugs having anticholinergic effects, such as amantadin, tricyclic antidepressants, a haloperidol, blockers histamine H1 of receptors, and procaineamide, excepting ipratropium, suppressing activity of a ciliate epithelium and reducing mukotsiliarny clearance, can lead to secret accumulation
- the raised doses of antibechic drugs, leads to suppression of a tussive reflex, therefore, removal of the bronchial secret which is formed in bigger quantity under the influence of Ambroxol is at a loss.
It is not recommended to apply Sekrazol® with codeine or other antibechic drugs containing codeine.
At the combined use of Sekrazol® can enhance efficiency
of antibacterial agents (ampicillin, amoksitsiklin, etc.) increasing their penetration into a bronchial secret.
Special instructions
With care are appointed in an abnormal liver function or kidneys, motor dysfunction of bronchial tubes or at discharge of a large amount of secretion (because of threat of an accumulation of slime). In heavy abnormal liver functions and kidneys it is necessary to reduce a dosage or to increase intervals between receptions.
Pregnancy and the period of a lactation
In spite of the fact that there are no reliable data of negative influence of SekrazolA® on a fruit and babies, use of SekrazolA® in II and III trimesters of pregnancy and in the period of a lactation perhaps after the careful analysis of a ratio advantage/risk the attending physician so far.
The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
Due to the possible developing of a headache to the patients accepting СЕКРАЗОЛ® should be careful during the driving of the car and occupations with other potentially dangerous types of activity, requiring special attention and speed of psychomotor reactions.
Overdose
Symptoms: nausea, vomiting, diarrhea, dyspepsia.
Treatment: it is necessary to cause vomiting, to wash out a stomach in the first 1-2 hours after administration of drug, symptomatic therapy.
The form of release and packing
On 10 tablets place in blister strip packaging from a film of white PVH/PE/PVDH and printing aluminum foil.
On 2, 3 or 5 planimetric packs together with the instruction for medical use in the state and Russian languages place in a pack cardboard with the hologram of firm – producer.
Storage conditions
At a temperature not higher than 25 ºС, in the dry, protected from light place. To store out of children's reach!
A period of storage
2 years
not to apply after the storage expiration
Prescription status
Without prescription
Republic of Kazakhstan JSC Nobel Almatinskaya Pharmatsevticheskaya Fabrika Producer,
Almaty, Shevchenko St. 162 E.
Owner of the registration certificate
of JSC Nobel Almatinskaya Pharmatsevticheskaya Fabrika
Republic of Kazakhstan
Trade name
СЕКРАЗОЛ®
the International unlicensed
name Ambroxol Dosage Form
of the Tablet of 30 mg
Structure
One tablet contains
active agent – Ambroxol a hydrochloride of 30 mg,
excipients: cellulose microcrystalline
HD90 (Prosolv SMCC HD90), lactose monohydrate, starch prezhelatinizirovanny, magnesium stearate, water
the Pharmacotherapeutic group cleaned the Description Round tablets of white color from risky on one party
Drugs for elimination of symptoms of cold and cough.
Mucolytics.
The code of automatic telephone exchange R05CB06
the Pharmacological
Pharmacokinetics Absorption properties - high, time of achievement of the maximum concentration - 2 hours, communication with proteins of blood plasma - 80%, gets through a blood-brain barrier, a placental barrier, is selected with breast milk.
After intake the action comes in 30 min. and continues within 6-12 hours.
Metabolism - in a liver, forms dibromantranilovy acid and glucuronic conjugates. Elimination half-life – 1.3 hours, and for the prolonged forms - 10-12 hours. It is removed by kidneys: 90% in the form of water-soluble metabolites, in not changed look - 5%.
Elimination half-life increases in heavy chronic kidney disease, but does not change in an abnormal liver function.
The pharmacodynamics
Possesses sekretomotorny, sekretolitichesky and expectorant action, stimulates serous cells of glands of a mucous membrane of bronchial tubes, increases the content of mucous secretion and discharge of surfactant in alveoluses and bronchial tubes, normalizes the broken ratio of serous and mucous components of a phlegm. Activating the hydrolyzing enzymes and strengthening release of lysosomes from cells Klara, reduces viscosity of a phlegm. Increases physical activity of cilia of a ciliary epithelium, increases mukotsiliarny transport of a phlegm.
Indications
- acute and chronic bronchitis
- pneumonia
- a chronic obstructive pulmonary disease
- bronchial asthma with the complicated phlegm otkhozhdeniye
- a bronchoectatic disease
the Route of administration and doses
Inside.
To adults and children 12 years are more senior: on 30 mg (1 tablet) of 3 times/days.
If necessary for strengthening of therapeutic effect it is possible to appoint 60 mg (2 tablets) of 2 times/days.
Children are 6-12 years old – on 15 mg (half of a tablet) 2-3 times a day
Duration of a course of treatment is appointed by the doctor individually.
The drug is taken after a meal, washing down with liquid.
Side effects
Seldom
- a headache
- nausea, vomiting, dryness in a mouth, a gastralgia, diarrhea
- reactions of hypersensitivity (skin rash, a face edema, dispnoe, an itching)
It is very rare
- allergic reactions - a Quincke's disease, an acute anaphylaxis, skin rash, a small tortoiseshell
of the Contraindication
- hypersensitivity to Bromhexine or its metabolite to Ambroxol in
the anamnesis
- a peptic ulcer of a stomach and duodenum in an aggravation stage
- pregnancy (I trimester)
- children's age up to 6 years
Medicinal interactions
Combined use of the drug Sekrazol® with:
- the atropine and other drugs having anticholinergic effects, such as amantadin, tricyclic antidepressants, a haloperidol, blockers histamine H1 of receptors, and procaineamide, excepting ipratropium, suppressing activity of a ciliate epithelium and reducing mukotsiliarny clearance, can lead to secret accumulation
- the raised doses of antibechic drugs, leads to suppression of a tussive reflex, therefore, removal of the bronchial secret which is formed in bigger quantity under the influence of Ambroxol is at a loss.
It is not recommended to apply Sekrazol® with codeine or other antibechic drugs containing codeine.
At the combined use of Sekrazol® can enhance efficiency
of antibacterial agents (ampicillin, amoksitsiklin, etc.) increasing their penetration into a bronchial secret.
Special instructions
With care are appointed in an abnormal liver function or kidneys, motor dysfunction of bronchial tubes or at discharge of a large amount of secretion (because of threat of an accumulation of slime). In heavy abnormal liver functions and kidneys it is necessary to reduce a dosage or to increase intervals between receptions.
Pregnancy and the period of a lactation
In spite of the fact that there are no reliable data of negative influence of SekrazolA® on a fruit and babies, use of SekrazolA® in II and III trimesters of pregnancy and in the period of a lactation perhaps after the careful analysis of a ratio advantage/risk the attending physician so far.
The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
Due to the possible developing of a headache to the patients accepting СЕКРАЗОЛ® should be careful during the driving of the car and occupations with other potentially dangerous types of activity, requiring special attention and speed of psychomotor reactions.
Overdose
Symptoms: nausea, vomiting, diarrhea, dyspepsia.
Treatment: it is necessary to cause vomiting, to wash out a stomach in the first 1-2 hours after administration of drug, symptomatic therapy.
The form of release and packing
On 10 tablets place in blister strip packaging from a film of white PVH/PE/PVDH and printing aluminum foil.
On 2, 3 or 5 planimetric packs together with the instruction for medical use in the state and Russian languages place in a pack cardboard with the hologram of firm – producer.
Storage conditions
At a temperature not higher than 25 ºС, in the dry, protected from light place. To store out of children's reach!
A period of storage
2 years
not to apply after the storage expiration
Prescription status
Without prescription
Republic of Kazakhstan JSC Nobel Almatinskaya Pharmatsevticheskaya Fabrika Producer,
Almaty, Shevchenko St. 162 E.
Owner of the registration certificate
of JSC Nobel Almatinskaya Pharmatsevticheskaya Fabrika
Republic of Kazakhstan
Related Products
