The instruction for medical use of Sangisept Torgovoye medicine the name Sangisept Mezhdunarodnoye the unlicensed name Is not present the Dosage form of the Tablet Structure One Tablet contains active agents: propolis tincture – 60.0 mg, ascorbic acid – 5.0 mg excipients: citric acid, sugar, calcium stearate, essence fruit. The description of the Tablet from light yellow till yellow color, with a flat surface with a facet, with risky. On a surface of tablets impregnations are allowed. Pharmacotherapeutic group Drugs for treatment of diseases of a throat. Antiseptic agents. Other drugs. ATX R02AA20 code. The pharmacological Pharmacokinetics Action properties of propolis is cumulative action of its components therefore carrying out kinetic researches is not possible. Ascorbic acid is well soaked up after oral administration. About 25% contact plasma proteins, is postponed in plasma and cells, the highest concentration is reached in ferruterous fabrics (generally in bark of adrenal glands and a hypophysis). It is metabolized in a liver, removed with urine in the form of oxalate and in an invariable look. The pharmacodynamics Propolis - drug of natural origin on the basis of waste product of bees represents native mix of wax, the balsam substances, propolisny pitches, essential oils, wax, tannins, pollen containing a difficult complex of phenolic connections – the fenolkarbonovy acids (coffee, p-coumaric, ferulic) having biological activity and flavonoids. Resinous and balsam substances of propolis contain cinnamic alcohol, cinnamon acid, saturated acids - palmitic, stearin, from nonsaturated – olein and also benzoic acid which promotes together with other substances to antimicrobic effect of propolis. Propolis contains enzymes, vitamins A, B1, V2, E, S, RR, and microelements (aluminum, vanadium, iron, calcium, silicon, manganese, strontium). Propolis possesses anti-inflammatory, antimicrobic (concerning gram-positive bacteria), antipruritic and analgeziruyushchy properties (causes an analgesia of mucous membranes and skin, reduces morbidity of the struck fabrics), promotes growth of granulations, accelerates process of regeneration and epithelization of wound surfaces, stimulates metabolic processes. Under the influence of phenolic compounds of propolis the phagocytosis amplifies, there is a development of specific antibodies against various microorganisms and their toxins more vigorously. Being a natural antibiotic propolis does not oppress useful microflora of digestive tract, use does not lead it to dysbacteriosis and emergence of propolisorezistentny strains of microorganisms. Ascorbic acid fills shortage of vitamin C in an organism, has the significant antioxidant properties, regulates oxidation-reduction processes, increases body resistance to infections. Indications. Inflammatory diseases of a mouth and throat: - pharyngitis - tonsillitis - a catarrhal ulitis - aphthous stomatitis - a periodontal disease the Route of administration and doses hold the Tablet in a mouth before full resorption. For adults the maximum single dose 4 tablets, a daily dose of 12 tablets. For children over 6 years maximum single dose 2 tablets, daily dose of 6 tablets. A course of treatment – before disappearance of signs of inflammation - 5-8 days. Side effects - are possible allergic reactions (itching, erubescence, rash) Is very rare - dryness in a mouth, unpleasant feelings in a stomach, loss of appetite - dizziness, drowsiness, heartbeat. Contraindications - hypersensitivity to drug components - individual intolerance (hypersensitivity to pchelouzhaleniye, other products of beekeeping) - bronchial asthma - eczema - diathesis - children's age up to 6 years Medicinal interactions Propolis increases activity of such antibiotics as penicillin, streptomycin, tetracycline, Neomycinum, Monomycinum, polymyxin. Interaction with drugs of ascorbic acid arises at its prolonged use in high doses more often. Ascorbic acid increases concentration in blood of salicylates (increases risk of a crystalluria), ethinylestradiol, benzylpenicillin and tetracyclines. With estrogen - hormone level in blood serum increases. With the oral kotratseptiva containing estrogen - the contraceptive effect decreases. Reduces anti-coagulative effect of derivatives of coumarin. Improves absorption in intestines of iron preparations. Special instructions At development of allergic reactions treatment should be stopped. Patients with diabetes or the patients who are on a diet with the lowered content of sugar have to consider that each tablet contains 582 mg of sugar. Pregnancy and the period of a lactation Use is possible after coordination with the doctor. Features of influence of drug on ability to run the vehicle or potentially dangerous mechanisms. The Overdose Symptoms does not influence: strengthening of side effects, increase in quantity of leukocytes in blood is possible. Treatment. It is necessary to cancel drug. The form of release and packing On 10 tablets place in planimetric bezjyacheykovy packing from paper packing with a polymeric covering from two parties. On 250 planimetric packs together with iinstruktion on medical use in the state and Russian languages place in a cardboard box (group packing). To Store storage conditions in the dry, protected from light place, at a temperature not above 25 °C. To store out of children's reach! 2 years not to apply a period of storage after an expiration date. Prescription status Without prescription Eykos-Pharm LLP Producer, the Republic of Kazakhstan, Almaty region, the settlement Boralday, 71 travel. The owner of the registration certificate of Eykos-Pharm LLP, Kazakhstan the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers concerning quality of products (goods) Almaty, Nusupbekov St., 32
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