The instruction for use of dietary supplement to food Structure 1 bag contains active agent - a glycosamine sulfate (in the form of sulfate glycosamine potassium) 1500 mg. excipients: E420 sorbitol, E951 aspartame, citric acid anhydrous EZZO, macrogoal 4000. The description the Granulated powder of white or flavourless almost white color. A glycosamine sulfate represents salt of a natural aminomonosaccharide of the glycosamine which is physiologically present at a human body. The glycosamine is used in an organism by chondrocytes as starting material for synthesis of proteoglycans, glucosaminoglycans and hyaluronic acid of synovial fluid. Favorably influences metabolism of a cartilage - strengthens anabolic and weakens catabolic processes, increases permeability of the articulate capsule, restores enzymatic processes in cells of a synovial membrane and an articulate cartilage. Rotadon stimulates synthesis of proteoglycans and collagen, increases producing components of an extracellular matrix, at the same time properties of glucosaminoglycans and proteoglycans are close to physiological. Increase in synthetic activity of chondrocytes is followed by the inhibition of a hondrolizis caused by braking of activity of hondrolitichesky proteinases (collagenases, etc.) that is a basis of hondroprotektorny and osteotropny effects. The glycosamine shows moderate anti-inflammatory action which is not connected with suppression of synthesis of prostaglandins, and is implemented due to antioxidant activity (by blocking of formation of superoxidic radicals) and suppression of activity of lizoso-malny enzymes. The glycosamine initiates process of fixing of sulfur in synthesis of chondroitinsulphuric acid and promotes normal adjournment of calcium in a bone tissue, interferes with the damaging action of corticosteroids on chondrocytes and to the disturbance of synthesis of glucosaminoglycans induced by NPVS. Sulfonate groups also take part in synthesis of glucosaminoglycans and metabolism of cartilaginous tissue, and sulfoethers of side chains as a part of proteoglycans, promoting water keeping - in maintaining elasticity of a matrix of a cartilage. Rotadon stops destruction of a cartilage and reduces symptoms in an osteoarthrosis. Indications - prevention of inflammatory and initial manifestations of degenerative dystrophic diseases of joints of extremities (osteoarthrosis (osteoarthritis) of various localization, including arthrosis of knee and coxofemoral joints) - prevention of degenerative dystrophic diseases of a backbone (osteochondrosis, a spondylarthrosis, etc.) - prevention of a chondromalacia of a patella - prevention of a humeroscapular periarthritis - recovery of mobility and reduction of pain at damage of the joint and copular device - in a complex of rehabilitation actions after injuries of joints. Side effects - a meteorism, diarrhea, a constipation, pains in epigastriums - a small tortoiseshell, naggers Protivopokazaniya - individual - intolerance (including a gilerchuvstvi-telnost in the anamnesis) product components - pregnancy and the period of a lactation - children aged up to 1.2 years - the profound renal failure - phenylketonuria (contains aspartame) the Route of administration and doses For intake. Rotadon appoint the adult on 1 bag (1500 mg) of 1 times a day in 20 minutes prior to food. Contents of a bag should be dissolved completely in a glass of warm water and to drink right after preparation. Duration of reception is 4-12 weeks. If necessary the course of reception can be repeated with an interval of 2 months. Interactions At the combined use absorption of tetracyclines, reduces penicillin, chloramphenicol. The Rotadon product is compatible to non-steroidal anti-inflammatory drugs and glucocorticoids. At combined use with non-steroidal anti-inflammatory drugs enhances anti-inflammatory and analgesic effect of the last. A release form Powder for preparation of solution for intake in bags. 10 or 20 bags together with the instruction in the state and Russian languages to a cardboard box. To Store storage at a temperature not above 25 °C. To store out of children's reach! Z years not to apply a period of storage after an expiration date. The producer the Owner of a trademark and the certificate of registration is the ROTAFARM company, GREAT BRITAIN. Uorld Meditsin Ilach Sang.Be Tidzh is made. A.Sh. (Turkey). The address of the organization accepting in the territory of the Republic of Kazakhstan claims from the consumer on quality of products (goods) of RK, Almaty, Suyunbaya 222 St. of B Ph. / fax: +7 (7272) 529090 Is not medicine.